International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2019.465.477El-ShitanyNagla Abd El-Aziz AbbasAymn Tallat AliSoad Shaker EidBasma HarakehSteve NeamatallahThikryat Al-AbdAhmed MousaShaker 42019154Background and Objective: Ellagic acid (ELL) is a phenolic constituent of natural sources with antioxidant and anti-inflammatory activities. The ELL has a low bio-availability, therefore a nanoparticles (NP ELL) was formulated to determine whether NP ELL could alleviate cisplatin (CISP)-induced hepatotoxicity in comparison to a high dose of regular ELL. Materials and Methods: The NP ELL was prepared using an emulsion solvent diffusion technique. Hepatotoxicity was induced in rats using CISP (7.5 mg kg1). Rats were pre-treated with either 10 ELL (10 mg kg1), 1 NP ELL (1 mg kg1) or 2 NP ELL (2 mg kg1). Results: All ELL regimens significantly decreased CISP-induced increases in liver enzymes, MDA, NO, TNF-α, NFkB and BAX. Additionally, all significantly restored hepatic GSH, GPx, CAT and Bcl-2. Rat’s liver showed no injury in all ELL pretreated groups. Importantly, NP ELL did not inhibit the cytotoxic effect CISP against HCT116 cell lines. Conclusion: The NP ELL has improved bio-availability and protected against CISP induced hepatotoxicity. This provides an encouraging way of ameliorating the bio-availability of ELL while sustaining its desirable therapeutic effects.]]>Dasari, S. and P.B. Tchounwou,2014740364378Cui, W., E.M. Yazlovitskaya, M.S. Mayo, J.C. Pelling and D.L. Persons,200029219228Barabas, K., R. Milner, D. Lurie and C. Adin,20086118Kuhlmann, M.K., G. Burkhardt and H. Kohler,19971224782480Zicca, Z., S. Cafaggi, M.A. Mariggio, M.O. Vannozzi and M. Ottone et al.,2002442265272Mora, L.de.O., L.M.G. Antunes, H.D.C. Francescato and M.de.L.P. Bianchi,200347517522Kim, Y.K., J.S. Jung, S.H. Lee and Y.W. Kim,19972+ in cisplatin-induced cell injury in rabbit renal cortical slices.]]>146261269Gong, C., L. Qian, H. Yang, L.L. Ji and H. Wei et al.,20152015Pratibha, R., R. Sameer, P.V. Rataboli, D.A. Bhiwgade and C.Y. Dhume,2006532290293Yüce, A., A. Ateşşahin, A.O. Çeribaşı and M. Aksakal,2007101345349Giridharan, V.V., R.A. Thandavarayan, H.N. Bhilwade, K.M. Ko, K. Watanabe and T. Konishi,2012465060Srivastava, R.C., A. Farookh, N. Ahmad, M. Misra, S.K. Hasan and M.M. Husain,19969139142Omar, H.A., W.R. Mohamed, H.H. Arab and E.S.A. Arafa,20162016Omar, H.A., W.R. Mohamed, E.S.A. Arafa, B.A. Shehata, G.A. El Sherbiny, H.H. Arab and A.N.A. Elgendy,201668349356Chen, K.H., M.S. Weng and J.K. Lin,200773215227Sak, K.,20148122146Soong, Y.Y. and P.J. Barlow,200488411417Vattem, D.A. and K. Shetty,200529234266Baek, B., S.H. Lee, K. Kim, H.W. Lim and C.J. Lim,201620269277Festa, F., T. Aglitti, G. Duranti, R. Ricordy, P. Perticone and R. Cozzi,2001in vitro revealed by the comet assay.]]>2139033908Han, D.H., M.J. Lee and J.H. Kim,20062636013606Rogerio, A.P., C. Fontanari, E. Borducchi, A.C. Keller and M. Russo et al.,2008Lafoensia pacari and ellagic acid in a murine model of asthma.]]>580262270Marin, M., R.M. Giner, J.L. Rios and M.C. Recio,2013150925934Favarin, D.C., M.M. Teixeira, E.L. de Andrade, C.F. Alves and J.E.L. Chica et al.,20132013Priyadarsini, K.I., S.M. Khopde, S.S. Kumar and H. Mohan,20025022002206Urfalioglu, A., F.M. Yazar, B. Bilal, F.I. Tolun, H. Oksuz, O.F. Boran and G. Oksuz,201711217225Dubey, A., D.W. Park, J.E. Kwon, Y.J. Jeong and T. Kim et al.,201510227240Mady, F.M. and M.A. Shaker,20171274057417Zhang, H.M., L. Zhao, H. Li, H. Xu, W.W. Chen and L. Tao,20141192100Ahire, V., A. Kumar, K.P. Mishra and G. Kulkarni,201769904910Bala, I., V. Bhardwaj, S. Hariharan and M.R. Kumar,200640206210Lei, F., D.M. Xing, L. Xiang, Y.N. Zhao, W. Wang, L.J. Zhang and L.J. Du,2003796189194Seeram, N.P., R. Lee and D. Heber,2004Punica granatum L.) juice.]]>3486368Bala, I., V. Bhardwaj, S. Hariharan, S.V. Kharade, N. Roy and M.N.V.R. Kumar,2006142734Watkins, R., L. Wu, C. Zhang, R.M. Davis and B. Xu,20151060556074El‐Shitany, N.A. and B. Eid,20173219521963Skehan, P., R. Storeng, D. Scudiero, A. Monks and J. McMahon et al.,19908211071112Mahmoud, A.M., A.M. Al-Abd, D.A. Lightfoot and H.A. El-Shemy,201227673679Sonaje, K., J.L. Italia, G. Sharma, V. Bhardwaj, K. Tikoo and M.R. Kumar,200724899908Yilmaz, H.R., M. Iraz, S. Sogut, H. Ozyurt, Z. Yildirim, O. Akyol and S. Gergerlioglu,200450287290Conklin, K.A.,200037118Neamatallah, T., N.A. El-Shitany, A.T. Abbas, S.S. Ali and B.G. Eid,2018937433754Omur, A.D. and K. Coyan,2016611016Yousef, A.I., O.S. El-Masry and M.A. Abdel Mohsen,201617743748Tadagavadi, R.K. and W.B. Reeves,201018549044911Chou, W.Y., C.N. Lu, T.H. Lee, C.L. Wu and K.S. Hung et al.,200627469476Shaw, J., B. Chen, W.H. Huang, A.R. Lee and F.A. Valeriote,2011in vivo.]]>9129137Rehman, M.U., N. Ali, S. Rashid, T. Jain and S. Nafees et al.,20146610501059Lawrence, T.,2009κB pathway in inflammation.]]>2009Koppelman, B., J.J. Neefjes, J.E. de Vries and R. de Waal Malefyt,19977861871Knolle, P.A., A. Uhrig, S. Hegenbarth, E. Loser, E. Schmitt, G. Gerken and A.W. Lohse,1998114427433Kang, K.P., D.H. Kim, Y.J. Jung, A.S. Lee and S. Lee et al.,20092430123020Ma, Z.N., Y.Z. Li, W. Li, X.T. Yan and G. Yang et al.,2017Panax quinquefolius against cisplatin-induced acute kidney injury.]]>2017Gu, L., W.S. Deng, Y. Liu, C.H. Jiang and L.C. Sun et al.,201422341345Morgan, M.J. and Z.G. Liu,201021103115Hritcu, L., E. Bagci, E. Aydin and M. Mihasan,2015Ferulago angulata essential oil against scopolamine-induced memory impairment in laboratory rats.]]>4017991809Jiang, M., C.Y. Wang, S. Huang, T. Yang and Z. Dong,2009296F983F993