International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2019.151.155Moringa peregrina Seed Ethanolic Extract]]>Abbas AlbaayitShaymaa Fadhel OzaslanMehmet 12019151Background and Objective:Moringa peregrina have long been used as traditional medicine to treat diseases including fever, ulcer, burns and constipation, antimicrobial and inflammatory throughout the African mainland. The objectives of current study were to evaluate the cytotoxic and urease inhibitory profile of Moringa peregrina seed ethanolic extract (MPSE). Materials and Methods: Brine shrimp lethality bioassay was used to determine the cytotoxic effect of MPSE treatment at concentrations 1000, 100 and 10 μg mL1. Urease inhibition was determined by in vitro Indophenol inhibition assays. Results: It is found that the Moringa peregrina seed ethanolic extract was not cytotoxic at 1000 μg mL1 while significantly active with urease inhibitor (81.30±0.31% at 0.2 mg mL1) with IC50 values of 41.0±0.6 μg mL1. Conclusion: These findings suggested that the Moringa peregrina seed ethanol extract (MPSE) can be utilized to treat and prevent ulcerative and Urolithiasis diseases through urease inhibition process. Seed extract of M. peregrina is a remarkable candidate for further clinical investigation studies to screen out their natural therapeutic potential in ulcerative and urolithiasis diseases.]]>Senthilkumar, A., N. Karuvantevida, L. Rastrelli, S.S. Kurup and A.J. Cheruth,2018Moringa peregrina (Forssk.) Fiori.-A review.]]>2018El-Hak, H.N.G., A.R.A. Moustafa and S.R. Mansour,2018Moringa peregrina seeds on histological and biochemical analyses of adult male Albino rats. ]]>53845Al-Majali, I.S., S.A. Al-Oran, M.R. Hassuneh, H.N. Al-Qaralleh and W.A. Rayyan et al.,2017Moringa peregrine leaves, ex vivo and in vivo study.]]>42231238Koheil, M.A., M.A. Hussein, S.M. Othman and A. El-Haddad,2011Moringa peregrina seeds.]]>14961Selvakumar, D. and P. Natarajan,2008Moringa oleifera Lam leaves in carbon tetrachloride induced hepato-toxicity in albino rats.]]>49798Elbatran, S.A., O.M. Abdel-Salam, K.A. Abdelshfeek, N.M. Nazif, S.I. Ismail and F.M. Hammouda,2005Moringa peregrine (Forssk) Fiori.]]>11199206Ghaffari, M.A., B.A. Chaudhary, M. Uzair and K. Ashfaq,2016Heliotropium dasycarpum L.]]>13194198Meyer, B.N., N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols and J.L. McLaughlin,1982453134Ismail, A., J. Hussain, K. Arif-ullah, A.L. Khan and L. Ali et al.,20122012Pervez, H., M.S. Iqbal, M.Y. Tahir, F.U.H. Nasim, M.I. Choudhary and K.M. Khan,2008In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4-substituted isatin-3-thiosemicarbazones.]]>23848854Albaayit, S.F.A., Y. Abba, R. Abdullah and N. Abdullah,2014Clausena excavate leaves extract.]]>2014Geran, R.I.,197231727Martin, P.R. and R.P. Hausinger,1992Klebsiella aerogenes urease.]]>2672002420027Lalas, S., O. Gortzi, V. Athanasiadis, J. Tsaknis and I. Chinou,2012Moringa peregrine seed oil.]]>1723302334Padayachee, B. and H. Baijnath,2012658315839Ateeq-ur-Rehman, A. Mannan, S. Inayatullah, M.Z. Akhtar, M. Qayyum and B. Mirza,2009Thymus serpyllum.]]>47628633Ahmad, M.S., M. Hussain, M. Hanif, S. Ali and B. Mirza,20071223482363Upadhyay, L.S.B.,201211381388Verma, V.K., N. Singh, P. Saxena and R. Singh,2012Moringa oleifera (Lam) leaves against aspirin and ethanol induced gastric ulcer in rats.]]>24657 Saleh, N.M., M.I. Mabrouk, M.M. Salem-Bekhit and E.H. Hafez,2017Moringa peregrine Forssk as an antimicrobial agent against multi-drug-resistant Salmonella sp.]]>31380386Zahid, H., G.H. Rizwani, H. Shareef and S.T. Ali,2014Hibiscus schizopetalus (Mast) Hook.]]>20711Cheenpracha, S., E.J. Park, B. Rostama, J.M. Pezzuto and L.C. Chang,20108429437El-Alfy, T.S., S.M. Ezzat, A.K. Hegazy, A.M.M. Amer and G.M. Kamel,2011Moringa peregrina (Forssk.) Fiori. (Family: Moringaceae) growing in Egypt.]]>7109115Fahey, J.W., K.K. Stephenson, K.L. Wade and P. Talalay,2013Helicobacter pylori is inactivated by sulforaphane and other isothiocyanates.]]>43517