International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2018.68.75Xiao-tongWangFanHeXiao-lingSun12018141Background and Objective:Schisandra chinensis (S. chinensis) (Turcz., Bail.), is Chinese traditional herbal medicine and the schisandra lignans are the major constituents of S. chinensis responsible for the nephroprotective effect. However, there was no study done on pharmacokinetics of schisandra lignans in Alzheimer’s disease (AD) rat plasma after oral Schisandra chinensis extract (SCE). The aim of this study was to investigate the pharmacokinetic profiles of 7 lignans after oral administration of SCE and compared the difference of the pharmacokinetics profiles between normal and Alzheimer’s disease rats. Materials and Methods: The plasma concentrations of 7 lignans were determined by using a simple and rapid high-performance liquid chromatography. All the rats were divided randomly into two groups (Alzheimer’s and normal groups). Each group received oral administration of 0.1 g kg–1 SCE. The relevant pharmacokinetic parameters were calculated by using the computer program DAS 2.0. Results: The results showed that 7 lignans of Schisandra chinensis could be detected in rat plasma after oral administration of SCE to rats. Gomisin D and schisantherin A had shown better absorption than other lignans. Oral administration of SCE, AD rats showed better absorption than normal rats. Conclusion: It can be concluded that the pharmacokinetics properties of 7 lignans differed between Alzheimer’s rats and normal rats, including AUC(0-t) and Cmax (p<0.05).]]>Francis, P.T., A.M. Palmer, M. Snape and G.K. Wilcock,1999J. Neurol. Neurosurg. Psychiatry,66137147Kang, S.Y., K.Y. Lee, K.A. Koo, J.S. Yoon, S.W. Lim, Y.C. Kim and S.H. Sung,2005Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.]]>Life Sci.,7616911705Cui, X., P. Zuo, Q. Zhang, X. Li and Y. Hu et al.,2006J. Neurosci. Res.,8315841590Long, J., X. Wang, H. Gao, Z. Liu and C. Liu et al.,2007Biogerontology,8373381Lu, J., Y.L. Zheng, L. Luo, D.M. Wu, D.X. Sun and Y.J. Feng,2006Behav. Brain Res.,171251260Lu, J., D.M. Wu, Y.L Zheng, B. Hu and Z.F. Zhang et al.,2010Cerebral Cortex,2025402548He, M., L. Zhao, M.J. Wei, W.F. Yao, H.S. Zhao and F.J. Chen,2009Biol. Pharm. Bull.,325560Lei, M., Y. Su, X. Hua, J. Ding, Q. Han, G. Hu and M. Xiao,2008Neuroreport,1916111615Chinese Pharmacopoeia Commission,2015Pharmacopoeia of the People's Republic of China 2015.Liu, H., J. Zhang, X. Li, Y. Qi, Y. Peng, B. Zhang and P. Xiao,2012Schisandra sphenanthera by HPLC-PAD-MS.]]>Phytomedicine,1912341241Zhang, W.D., Q. Wang, Y. Wang, X.J. Wang, J.X. Pu, Y. Gu and R. Wang,2012Schisandrae chinensis.]]>J. Sep. Sci.,3522032209Liang, Y., H. Hao, L. Xie, A. Kang and T. Xie et al.,2010Schisandra lignans in rats.]]>Drug Metab. Dispos.,3817471759National Research Council,1996National Science Education Standards.Wu, X., Y. Zhou, F. Yin, G. Dai and L. Li et al.,2014Biomed. Chromatogr.,2810751083Kim, Y.J., H.J. Lee, C.Y. Kim, S.Y. Han, Y.W. Chin and Y.H. Choi,2014Schisandra chinensis extract using ultra-performance liquid chromatography with tandem mass spectrometry in rat plasma, urine and gastrointestinal tract samples: Application to the pharmacokinetic study of Schisandra chinensis.]]>J. Sep. Sci.,3728512863Wang, B.L., J.P. Hu, W. Tan, L. Sheng, H. Chen and Y. Li,2008Schisandra chinensis (Wuweizi) in rat plasma using liquid chromatography/mass spectrometry.]]>J. Chromatogr. B: Anal. Technol. Biomed. Life Sci.,865114120