International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2018.633.639LeiLirong WuYan LuShengqiang ZhaoBin LiuYishu 52018145Background and Objective: Depression is a psychiatric disorder and inflammation facilitates the depression. Complexity of symptoms related to depression among different individuals and different therapeutic responses exhibited by the use of available antidepressants show that a need to identify novel antidepressants is there. Thus present study evaluates the effect of Triptolide (TPL) on depressive like behavior induced by lipopolysaccharide (LPS) in mice. Materials and Methods: All the mice were challenged with LPS (0.83 mg kg1, i.p.) 30 min after the administration of 5 mg kg1 of TPL. Several behavioral parameters were studied including open field test, forced swim test, tail suspension test and sucrose preference test. The level of pro-inflammatory cytokines and oxidative stress parameters were estimated in the brain tissues of LPS challenged mice. Moreover, level of brain derived neurotrophic factor (BDNF) in the brain tissues and plasma concentration of corticosteroid was estimated in LPS challenged mice. Results: Data given in the study suggested that treatment with TPL attenuates the behavioral parameters affected by LPS in mice. Level of pro-inflammatory cytokines and oxidative stress parameters were significantly decreases in the prefrontal cortex and hippocampus of TPL treated group compared to negative control group. Plasma concentration of corticosteroid significantly decreases and level of BDNF in brain tissue significantly increases in TPL treated group than negative control group of mice. Conclusion: Present study concludes that treatment with TPL attenuates the depressive behavior by decreasing the level of cytokines and oxidative stress parameter in the brain tissues of LPS challenged mice.]]>Garcia-Bueno, B., J.R. Caso and J.C. Leza,20083211361151Howren, M.B., D.M. Lamkin and J. Suls,200971171186Bromet, E., L.H. Andrade, I. Hwang, N.A. Sampson and J. Alonso et al.,20112011Mello, B.S.F., A.S. Monte, R.S. McIntyre, J.K. Soczynska and C.S. Custodio et al.,20134715211529Song, C. and H. Wang,201135760768Uher, R., O. Mors, M. Rietschel, A. Rajewska-Rager and A. Petrovic et al.,20117214781484Nestler, E.J., M. Barrot, R.J. DiLeone, A.J. Eisch, S.J. Gold and L.M. Monteggia,2002341325Liu, Q.,201111377383Zheng, Y., W.J. Zhang and X.M. Wang,2013197682Takaishi, Y., K. Ujita, H. Tokuda, H. Nishino, A. Iwashima and T. Fujita,1992651926Li, X.Y.,1993Tripterygium wilfordii Hook F.]]>9181187O'Connor, J.C., M.A. Lawson, C. Andre, M. Moreau and J. Lestage et al.,200914511522Zhang, C. and M.S. Zhang,201691556815574Santosh, P., R. Venugopl, A.S. Nilakash, S. Kunjbihari and L. Mangala,2011Passiflora foetida leaves in mice.]]>3112115Porsolt, R.D., A. Bertin and M. Jalfre,1977229327336Steru, L., R. Chermat, B. Thierry and P. Simon,198585367370Henry, C.J., Y. Huang, A. Wynne, M. Hanke and J. Himler et al.,20082008Jangra, A., A.K. Datusalia, S. Khandwe and S.S. Sharma,20131144351Beutler, E., O. Duron and B.M. Kelly,196361882888Engeland, C.G., M. Kavaliers and K.P. Ossenkopp,200374433447Raison, C.L. and A.H. Miller,201113467475Biesmans, S., T.F. Meert, J.A. Bouwknecht, P.D. Acton and N. Davoodi et al.,20132013Van Heesch, F., J. Prins, J.P. Konsman, K.G. Westphal, B. Olivier, A.D. Kraneveld and S.M. Korte,20132998103Wu, T.H. and C.H. Lin,2008193183191