International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2018.239.247 Lauridia tetragona (L.F.) R.H. Archer Leaf in Wistar Rats]]>WintolaOlubunmi Abosede AfolayanAnthony Jide 22018142Background and Objective: Medicinal plants are used in the treatment and management of various diseases. The usage of herbs and their formulations have witnessed progressive increase among the populace especially in the rural areas because of the notion that these products are safe and free from undesirable side effects. This study was aimed at evaluating the toxicological potential of aqueous extract of Lauridia tetragona leaf in Wistar rats. Methodology: The acute toxicity test was performed with single oral administration of 5000 mg kg1 b.wt., of L. tetragona extract to rats and the animals were observed for 14 days for signs of toxicity. This was followed by subacute toxicity experiment conducted by oral administration of graded doses (50, 100 and 200 mg kg1) of L. tetragona extract daily for 28 days. Behavioural changes as well as haematological, biochemical and histological parameters were then evaluated. Data were analysed using two-way ANOVA with the aid of GraphPad Prism software. Results: Results revealed significant reduction (p<0.05) in the feed intake, serum glucose, lymphocytes and platelet levels of extract treated rats compared to the control. There were also some alterations in the liver and kidney function parameters. However, there were no treatment related differences in the histopathological evaluations. Conclusion: It can be concluded that administration of aqueous extract of L. tetragona may be safe at the dosages tested in this study but its continuous usage can cause anorexia.]]>WHO,2002Pages: 61Pages: 61Awodele, O., I.A. Oreagba, S. Odoma, J.A.T. da Silva and V.O. Osunkalu,2012Moringa oleifera Lam. (Moringaceae).]]>139330336Said, O., K. Khalil, S. Fulder and H. Azaizeh,200283251265Elvin-Lewis, M.,200175141164Archer, R.H. and A.E. van Wyk,1997Lauridia Eckl. and Zeyh. (Cassinoideae: Celastraceae).]]>63227232Palgrave, K.C.,20023rd Edn.,Pages: 1212Pages: 1212De Vynck, J.C., B.E. Van Wyk and R.M. Cowling,20161026069OECD.,20012001Fredrickson, D.S., R.I. Levy and R.S. Lees,19672763444Ekanem, J.T. and O.K. Yusuf,2007198186Gornall, A.G., C.J. Bardawill and M.M. David,1949177751766Webster, D.,197723663666Tietz, N.W.,19953rd Edn.,Krause, W.J.,2004pp: 9-10pp: 9-10Ezeja, M.I., A.O. Anaga and I.U. Asuzu,2014Gouania longipetala in rats.]]>15111551164Olorunnisola, O.S., G. Bradley and A.J. Afolayan,2012Tulbaghia violacea rhizomes in Wistar rats.]]>111493414940Lopes, L.D.C., F. Albano, G.A.T. Laranja, L.M. Alves and L.F.M. Silva et al.,2000in vitro and in vivo assays of an aqueous extract prepared from Echinodorus macrophyllus leaves.]]>116189198Anwar, F. and M.I. Bhanger,2003Moringa oleifera seed oil grown in temperate regions of Pakistan.]]>5165586563Elderdery, A.Y. and A.S. Alshaiban,20176611Chandrashekar, V.,201322226Gray, A.M., Y.H.A. Abdel-Wahab and P.R. Flatt,2000Sambucus nigra (elder), exhibits insulin-like and insulin-releasing actions in vitro.]]>1301520Voet, D., J.G.P. Voet, W. Charlotte, G.V. Judith and W.P. Charlotte,2013Shahjahan, M., K.E. Sabitha, M. Jainu and C.S. Shyamala-Devi,2004Solanum trilobatum against carbon tetrachloride induced hepatic damage in albino rats.]]>120194198Akanji, M.A., M.T. Yakubu and M.I. Kazeem,2013Rauvolfia vomitoria Afzel root in Wistar rats.]]>13253260Antonelli-Ushirobira, T.M., E.N. Kaneshima, M. Gabriel, E.A. Audi, L.C. Marques and J.C.P.D. Mello,2010Paullinia cupana) in rodents.]]>4818171820Moe, S.M., T. Drueke, N. Lameire and G. Eknoyan,200714312