International Journal of Pharmacology 1811-7775 1812-5700 Asian Network for Scientific Information 10.3923/ijp.2018.144.150 Conyza bonariensis and its Fractions in Rodents Models]]> Bukhari Ishfaq Ali Sheikh Saeed Ahmed Shaikh Nadeem Ahmad Assiri Asaad Mohamed Gilani Anwar Hassan 1 2018 14 1 Background and Objective: Several species of Conyza bonariensis (C. bonariensis) and related species are used traditionally in the management of pain and inflammatory conditions. The current study was aimed to evaluate the analgesic and anti-inflammatory activities of C. bonariensis in animal models of pain and inflammation. Methodology: For the analgesic effect, acetic acid and formalin-induced models of nociception were employed while the anti-inflammatory effect was assessed in the carrageenan-induced rat paw edema test. The data were analyzed by student’s t-test and one-way ANOVA followed by Tukey-Kramer multiple comparisons. Results: The intraperitoneal (i.p.) administration of the methanolic extract (50-100 mg kg–1), butanol, chloroform and hexane fractions (25-50 mg kg–1 i.p) produced significant inhibition (p<0.01) of the acetic acid-induced writhing in mice and suppressed formalin-induced licking response of animals in the second phase of the test. C. bonariensis (50-200 mg kg–1 i.p.) produced marked anti-inflammatory effect in the carrageenan-induced rat paw edema assay comparable to indomethacin. Among various fractions of the plant, hexane and butonalic acid exhibited significant (p<0.05) anti-inflammatory effects. Conclusion: It is concluded that C. bonariensis possesses analgesic and anti-inflammatory properties and that the bioactive bhytochemicals appeared to be concentrated in the hexane and butonalic fractions.

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