International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.698.708SaeedMuhammad Abd El-HackMohamed Ezzat AlagawanyMahmoud NaveedMuhammad ArainMuhammad Asif ArifMuhammad SoomroRab Nawaz KakarMohibUllah ManzoorRobina TiwariRuchi KhandiaRekha MunjalAshok KarthikKumaragurubaran DhamaKuldeep IqbalHafiz Muhammad Nasir SunChao 72017137Green tea is an important herb and its products are extensively used in the traditional Chinese medicinal system through various formulations. Several reports have revealed its beneficial usage and medicinal aspects for various ailments. Consumption of green tea has gained special attention and popularity in various sectors of the modern era of changing lifestyle. This review aimed to extend the current knowledge on the modes of action and beneficial applications of green tea in humans and animals for safeguarding different health issues. The nutritional, immunological, pharmacological and physiological functionalities of green tea are because of the available bioactive components like caffeine, L-theanine, polyphenols/flavonoids and others. It possesses multi-beneficial potential in treating and preventing various disorders of animals and humans, as well as promoting animal (dairy, piggery and goatry) and poultry industry. The present review provides insights on the modes of action and beneficial applications of green tea, which will be useful for nutritionists, pharmacists, physiologists, researchers, veterinarians and animal and poultry producers. Future research emphasis and promotional avenues are needed to explore its potential therapeutic applications for designing appropriate pharmaceuticals, complementary medicines and effective drugs to popularize and propagate its multidimensional health benefits.]]>Anonymous,20052005Mosihuzzaman, M.,20127807812Mahima, A. Rahal, R. Deb, S.K. Latheef and H.A. Samad et al.,201215754774Dhama, K., S. Mani, S. Chakraborty, R. Tiwari, A. Kumar, P. Selvaraj and R.B. Rai,2013519081919Dhama, K.D., S. Sachan, R. Khandia, A. Munjal and H.M.N. Iqbal et al.,2017Tinospora cordifolia (Guduchi): A miraculous herb countering various diseases/disorders and its immunomodulatory effects.]]>1096111Yadav, A.S., G. Kolluri, M. Gopi, K. Karthik, Y.P.S. Malik and K. Dhama,20164368383Zeb-Ansari, J., A.H. Yousaf, T.M. Ahmad and S. Khan,200824323329Durrani, F.R., N. Chand, M. Jan, A. Sultan, Z. Durrani and S. Akhtar,200824655659Biu, A.A., S.D. Yusufu and J.S. Rabo,2009Azadirachta indica A. Juss) on haematological parameters in chicken.]]>10189192Nidaullah, H., F.R. Durrani, S. Ahmad, I.U. Jan and S. Gul,201055359Ayssiwede, S.B., J.C. Zanmenou, Y. Issa, M.B. Hane and A. Dieng et al.,201110707717Saeed, M., A.R. Baloch, M. Wang, R.N. Soomro and A.M. Baloch et al.,2015Cichorium intybus leaf extract as growth promoter, hepatoprotectant and immune modulent in broilers.]]>5585591Alagawany, M. and M.E. Abd El-Hack,201524341347Alagawany, M., E.A. Ashour and F.M. Reda,2016Allium sativum) and turmeric (Curcuma longa) on growth performance, carcass traits, blood profile and oxidative status in growing rabbits.]]>16489505Alagawany, M., M.E.A. El-Hack and M.S. El-Kholy,2016Yucca schidigera extract.]]>2367746782Conde, V.R., G.M. Alves, P.F. Oliveira and B.M. Silva,2015Camellia sinensis (L.)): A putative anticancer agent in bladder carcinoma?]]>152636Perumalla, A.V.S. and N.S. Hettiarachchy,201144827839Gupta, D.A., D.J. Bhaskar, R.K. Gupta, B. Karim, A. Jain and D.R. Dalai,20142812Delwing-Dal Magro, D., R. Roecker, G.M. Junges, A.F. Rodrigues and D. Delwing-de Lima et al.,20168314221427Wheeler, D.S. and W.J. Wheeler,2004614565Varilek, G.W., F. Yang, E.Y. Lee, W.J.S. deVilliers and J. Zhong et al.,200113120342039Chacko, S.M., P.T. Thambi, R. Kuttan and I. Nishigaki,20102010Haqqi, T.M., D.D. Anthony, S. Gupta, N. Ahmad, M.S. Lee, G.K. Kumar and H. Mukhtar,19999645244529Sano, M., M. Suzuki, T. Miyase, K. Yoshino and M. Maeda-Yamamoto,19994719061910Fujiki, H.,20055119132Butt, M.S., R.S. Ahmad, M.T. Sultan, M.M.N. Qayyum and A. Naz,201555792805Isogai, E., H. Isogai, K. Hirose, S. Hayashi and K. Oguma,2001In vivo synergy between green tea extract and levofloxacin against enterohemorrhagic Escherichia coli O157 infection.]]>42248251Weber, J.M., A. Ruzindana-Umunyana, L. Imbeault and S. Sircar,200358167173Muthu, M., J. Gopal, S.X. Min and S. Chun,2016180780790Jang, S.I., M.H. Jun, H.S. Lillehoj, R.A. Dalloul, I.K. Kong, S. Kim and W. Min,2007Eimeria maxima.]]>144172175Ryu, E.,1982Toxoplasma gondii in vitro and mice.]]>9126131Molan, A.L., L.P. Meagher, P.A. Spencer and S. Sivakumaran,2003in vitro egg hatching, larval development and viability of infective larvae of Trichostrongylus colubriformis.]]>3316911698Molan, A.L., S. Sivakumaran, P.A. Spencer and L.P. Meagher,2004Teladorsagia circumcincta and Trichostrongylus colubriformis in vitro.]]>77239243Shimamura, T., W.H. Zhao and Z.Q. Hu,200765762Fukuyo, M., Y. Hara and K. Muramatsu,198639495500Das, D.N.,196323219222Yoshino, K., I. Tomita, M. Sano, I. Oguni, Y. Hara and M. Nakano,1994177985Crespy, V. and G. Williamson,2004in vivo animal models.]]>1343431S3440SDa Silva Pinto, M.,201353558567Lee, L.S., S.H. Kim, Y.B. Kim and Y.C. Kim,20141991739186Vuong, Q.V., M.C. Bowyer and P.D. Roach,20119119311939Eschenauer, G. and B.V. Sweet,2006632630Montopoli, M., L.C. Stevens, C. Smith, G. Montopoli and S. Passino et al.,20152328White, D.J., S. de Klerk, W. Woods, S. Gondalia, C. Noonan and A.B. Scholey,20162016Deng, W.W., S. Ogita and H. Ashihara,2010487072Higashiyama, A., H.H. Htay, M. Ozeki, L.R. Juneja and M.P. Kapoor,20113171178Saito, K., M. Ikeda and H. Kametani,20112011Shen, H., X. Shen, R. Wang and M. Wu,201140684687Gong, Y., Y. Luo, J.A. Huang, J. Zhang, Y. Peng, Z. Liu and Z. Baolu,2012Caenorhabditis elegans.]]>4988993Li, L., X.R. Wang, Y. Xiong, W.K. Ren and M. Huang et al.,2013112527Culetu, A., B. Fernandez-Gomez, M. Ullate, M.D. del Castillo and W. Andlauer,20161971423Cooper, R.,2012639097Li, G., Y. Ye, J. Kang, X. Yao and Y. Zhang et al.,201250363372Thangarajan, S., A. Deivasigamani, S.S. Natarajan, P. Krishnan and S.K. Mohanan,2014124673684Balentine, D.A., S.A. Wiseman and L.C. Bouwens,199737693704Graham, H.N.,199221334350Heiss, M.L. and R.J. Heiss,2008Tian, X., L. Sun, L. Gou, X. Ling and Y. Feng et al.,201315032432Deng, W.W., S. Ogita and H. Ashihara,2008Camellia sinensis.]]>1115119Narukawa, M., Y. Toda, T. Nakagita, Y. Hayashi and T. Misaka,20141R1+ T1R3 umami taste receptor.]]>4615831587Chu, D.C.,19971997pp: 1-11pp: 1-11Juneja, L.R., D.C. Chu, T. Okubo, Y. Nagato and H. Yokogoshi,199910199204Song, H.J., Y.D. Kim, M.J. Jeong, M.S. Ahn, S.W. Kim, J.R. Liu and M.S. Choi,2015Camellia sinensis L.) trees and metabolites profiling by Fourier transform near-infrared (FT-IR) spectroscopy.]]>95565Boros, K., N. Jedlinszki and D. Csupor,2016127579Williams, J., J. Kellett, P.D. Roach, A. McKune, D. Mellor, J. Thomas and N. Naumovski,20162016Chaturvedula, V.S.P. and I. Prakash,2011521102124Kaneko, S., K. Kumazawa, H. Masuda, A. Henze and T. Hofmann,20065426882694Horanni, R. and U.H. Engelhardt,20133194100Khan, S.H.,2014Camellia sinensis) as a phytogenic substance in poultry diets.]]>8118Zaveri, N.T.,20067820732080Abdel-Rahman, A., N. Anyangwe, L. Carlacci, S. Casper and R.P. Danam et al.,2011123333348Abdo, Z.M.A., R.A. Hassan, A. Abd El-Salam and S.A. Helmy,20103011211149Karori, S.M., F.N. Wachira, J.K. Wanyoko and R.M. Ngure,2007622872296Scheid, L., S. Ellinger, B. Alteheld, H. Herholz and J. Ellinger et al.,201214220912096Konishi, S. and E. Takahashi,196940479484Orihara, Y. and T. Huruya,199096568Kawagishi, H. and K. Sugiyama,199256689689Ekamayake, A. and J.J. Li,20072007Baudouin, S.X.,20102010Deng, W.W., Y. Fei, S. Wang, X.C. Wan, Z.Z. Zhang and X.Y. Hu,2013Camellia sinensis seedlings.]]>71295299Deng, W.W. and H. Ashihara,2015Camellia sinensis).]]>10703706Mason, R.,200179195Kimura, K., M. Ozeki, L.R. Juneja and H. Ohira,2007743945Birketvedt, G.S.,20162016Record, I.R., J.K. McInerney and I.E. Dreosti,1996532743Deng, Z., B. Tao, X. Li, J. He and Y. Chen,1998657586Samman, S., B. Sandström, M.B. Toft, K. Bukhave, M. Jensen, S.S. Sørensen and M. Hansen,200173607612Mira, L., M.T. Fernandez, M. Santos, R. Rocha, M.H. Florencio and K.R. Jennings,20023611991208Nelson, M. and J. Poulter,2004174354Peng, B., Z. Liu, Y. Lin, H. Lin and J. Huang,201434355363Wen, H., S. Wei, S. Zhang, D. Hou, W. Xiao and X. He,2012L-theanine on performance and immune function of yellow-feathered broilers.]]>2419461954Hwang, Y.H., B.K. Park, J.H. Lim, M.S. Kim and I.B. Song et al.,2008Paenibacillus polymyxa and L-theanine on growth performance and immunomodulation in weanling piglets.]]>2117531759Tamano, H., K. Fukura, M. Suzuki, K. Sakamoto, H. Yokogoshi and A. Takeda,20139516Takeda, A., H. Tamano, M. Suzuki, K. Sakamoto, N. Oku and H. Yokogoshi,2012324148Yin, C., L. Gou, Y. Liu, X. Yin, L. Zhang, G. Jia and X. Zhuang,20112516361639Liang, Y.R., C. Liu, L.P. Xiang and X.Q. Zheng,20151419431949Zhang, G., X. Ye, D. Ji, H. Zhang and F. Sun et al.,2014585288543Koo, M.W.L. and C.H. Cho, 2004500177185Roychoudhury, S., A. Agarwal, G. Virk and C.L. Cho,201734487498Garcia, M.L., B.P. Roberto, E.E. Nishi, F.K. Ibuki, V. Oliveira and A.C.H. Sawaya,201735348354Liu J., S. Liu, H. Zhou, T. Hanson, L. Yang, Z. Chen and M. Zhou,201631853865Tsuneki, H., M. Ishizuka, M. Terasawa, J.B. Wu, T. Sasaoka and I. Kimura,20042004Chen, I.J., C.Y. Liu, J.P. Chiu and C.H. Hsu,201635592599Janssens, P.L.H.R., R. Hursel and M.S. Westerterp-Plantenga,20161628387Meydani, M.,2001928226235Hara, Y.,1990Lu, H., X. Meng, C. Li, S. Sang and C. Patten et al.,200331452461Takabayashi, F., N. Harada, M. Yamada, B. Murohisa and I. Oguni,2004Helicobacter pylori infection in Mongolian gerbils.]]>396163Carneiro, B.M., M.N. Batista, A.C.S. Braga, M.L. Nogueira and P. Rahal,2016496215218Chaudhary, N., J. Bhardwaj, H.J. Seo, M.Y. Kim, T.S. Shin and J.D. Kim,2014Camellia sinensis fruit peel extract inhibits angiogenesis and ameliorates obesity induced by high-fat diet in rats.]]>7479486Cunha, C.A., F.S. Lira, J.C. Rosa Neto, G.D. Pimentel and G.I.H. Souza et al.,20132013Kim, H.R., R. Rajaiah, Q.L. Wu, S.R. Satpute and M.T. Tan et al.,200813821112116Thitimuta, S., P. Pithayanukul, S. Nithitanakool, R. Bavovada, J. Leanpolchareanchai and P. Saparpakorn,2017Camellia sinensis L. extract and its potential beneficial effects in antioxidant, anti-inflammatory, anti-hepatotoxic and anti-tyrosinase activities.]]>2017Mollashahi, N.F., M. Bokaeian, L.F. Mollashahi and A. Afrougheh,2015Candida albicans biofilm on tooth substrate.]]>12592598Mora, A., J. Pawa, J.M. Chaverri and M.L. Arias,2013Camellia sinensis) against the potentially pathogenic microorganisms Escherichia coli, Salmonella enterica, Staphylococcus aureus, Listeria monocytogenes, Candida albicans and Aspergillus niger].]]>63247253, (In Spanish)