International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.603.611ChenDan XingHaihui JiangQiao XiangYunxia HuWei GuoHaiying 62017136Background and Objective: Cerebral apoplexy may develop infarcts in cerebral, cerebellar, or brain stem lesions.It may lead to developing dysphagia-a physiological complication. The objective of the study was to explore the effect of levetiracetam in the rehabilitation of dysphagia due to cerebral apoplexy. Materials and Methods: There were 638 patients with dysphagia due cerebral apoplexy enrolled for the study. Each patient of placebo, treatment and control groups was received placebo tablets, levetiracetam 500 mg film coated tablets and levodopa (in combination with carbidopa in 10:1 ratio) tablets twice daily for eight weeks respectively. Qualitative, quantitative measures of video fluorographic study, electroencephalography and mu rhythm of all patients were evaluated at theinitial stage and at the end of successful treatment of 8 weeks. The one-way ANOVA and the Wilcoxon test were used for all parameters to show a significant difference between groups and within the group at the 95% level of confidence. Results: There was a reduction in aberrant bolus movement, dorsal head compensation, abnormal posture and cough/gag at the end of treatment of in treatment group and control group with respectto theplacebo group. There was a significant improvement in bolus speed, mastication speed, jaw excursion, bolus area, alpha, beta and gamma oscillations after eight weeks of treatmentbetween placebo group and treatment group and placebo group and control group (p<0.05 for all). After 8 weeks of treatment, there was a significant improvement in alpha, beta and gamma oscillations between control group and treatment group (p<0.05). Conclusion: This study identified significant effect of levetiracetam in the rehabilitation treatments of dysphagia due to stroke.]]>Cohen, D.L., C. Roffe, J. Beavan, B. Blackett and C.A. Fairfield et al.,201611399411Martino, R., N. Foley, S. Bhogal, N. Diamant, M. Speechley and R. Teasell,20053627562763Cuellar, M., A.W. Harkrider, D. Jenson, D. Thornton, A. Bowers and T. Saltuklaroglu,201612726252635Kikuchi, T., Y. Michiwaki, S. Koshizuka, T. Kamiya and Y. Toyama,201780114123Marchina, S., G. Schlaug and S. Kumar,201524511520Mancopes, R., A.R. Busanello-Stella, L.S. Finger, A.P. Neu, A.D.B. Pacheco and M.S. Torriani,201315707712Vinogradova, L.V. and C.M. Van Rijn,20084911601168Levesque, M., C. Behr and M. Avoli,2015251825The University of Hong Kong,2010Russell, J.A., M.R. Ciucci, M.J. Hammer and N.P. Connor,20132894104Jestrovic, I., J.L. Coyle and E. Sejdic,20152015Rabiller, G., J.W. He, Y. Nishijima, A. Wong and J. Liu,2015162560525640Light, G.A., L.E. Williams, F. Minow, J. Sprock and A. Rissling et al.,20102010Mahajan, B.K.,20066th Edn.,pp: 152-155pp: 152-155Venketasubramanian, N., C.L.H. Chen, R.N. Gan, B.P.L. Chan and H.M. Chang et al.,200945460Venketasubramanian, N., C.L.H. Chen, R.N. Gan, B.P.L. Chan and H.M. Chang et al.,200945460Jones, T.A.,201718267280Mowlavi, S., J. Engmann, A. Burbidge, R. Lloyd, P. Hayoun, B. Le Reverend and M. Ramaioli,2016In vivo observations and in vitro experiments on the oral phase of swallowing of Newtonian and shear-thinning liquids.]]>4937883795Klitgaard, H., A. Matagne, R. Grimee, J. Vanneste-Goemaere and D.G. Margineanu,20031292100Park, D., Y. Oh and J.S. Ryu,201697421428Baijens, L.W., R. Speyer, V.L. Passos, W. Pilz, N. Roodenburg and P. Clave,20112011Mihai, P.G., M. Otto, M. Domin, T. Platz, S. Hamdy and M. Lotze,20161210131021Fattori, B., G. Siciliano, V. Mancini, L. Bastiani and P. Bongioanni et al.,201644306312Martin-Harris, B. and B. Jones,200819769785Burbidge, A., J. Cichero, J. Engmann and C. Steele,20162016