International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.507.515Huerta-ReyesMaira AnselmeCaroline CherquiAnas DecocqGuillaume 62017136Side effects and drug resistance are important limitations to the currently available treatments against cancer. It is challenging therefore to search for new drugs that are effective antitumoral agents with slight or no side effects. There is a growing interest in natural products, among which Hymenoptera venoms show promising properties since they exhibit a cytotoxic activity on a variety of cancer cell lines. The objective of this contribution is to provide an updated state of the art on Hymenoptera venoms as potential anticancer agents. The present reviewed literature comprise the pharmacological activity on cancer models of Hymenoptera venoms, with a special attention to bees and wasps venom components. 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