International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.361.369Smallanthus sonchifolius) for Human, Animals and Poultry]]>SaeedMuhammad YataoXu Ur RehmanZaib Asif ArainMuhammad Nawaz SoomroRab Abd El-HackMohamed E. Ahmed BhuttoZohaib AbbasiBenazir DhamaKuldeep SarwarMuhammad ChaoSun 42017134Non-digestible oligosaccharides as well as phenolic compounds inulins and fructooligosaccharides of Smallanthus sonchifolius make it an attractive functional food. Consumption of these non-digestible oligosaccharides improves gastrointestinal metabolism, increases the growth of bifido bacteria in the colon and also acts as antioxidant, antimicrobial, prebiotic, growth promoter, hypoglycemic, hepatoprotective compounds via lowering alanine aminotransferase (ALT) and increasing mineral absorption to maintain bone homeostasis and also help to reduce cholesterol and triglyceride levels. Past to present literature have been reviewed and the results indicated that Smallanthus sonchifolius root consumption modulates the immune system by regulating the intestinal secretion of IgA and interferon IFN-γ subsequently enhancing resistance to infections and allergic reactions. This role not only facilitates the exclusion of potential pathogenic bacteria but also ultimately increases defense of the host. Previously published literature has focused on rat, human, pig and livestock but biological and clinical evidence is scarce on the same aspect in poultry. Therefore, this review article aimed to highlight the origin, chemical composition, different beneficial uses and biohazards of yacon plant (which contains 70-80% fructooligosaccharides (FOS)) that could be used as a novel natural prebiotic in poultry feed. The FOS could improve different health aspects and productive performance criteria of different poultry species. To recommend yacon plant as a natural and safe medicinal agent, more indices need to be determined in further studies on different livestock and poultry species on molecular level to assure its benefits and to give accurate recommendation for the optimal levels to be added as feed additive.]]>Bernardeau, M., M. Gueguen, D.G.E. Smith, E. Corona-Barrera and J.P. Vernoux,2009In vitro antagonistic activities of Lactobacillus spp. against Brachyspira hyodysenteriae and Brachyspira pilosicoli.]]>138184190Abd El-Hack M.E., S.A. Mahgoub, M. Alagawany and K. Dhama,201511689696Alagawany, M. and M.E. Abd El-Hack,201524341347Alagawany, M., E.A. Ashour and F.M. Reda,2016Allium sativum) and turmeric (Curcuma longa) on growth performance, carcass traits, blood profile and oxidative status in growing rabbits.]]>16489505Mahmoud Mohamed Alagawany, Mayada Ragab Farag, Kuldeep Dhama2015Curcuma longa) Supplementation on Performance, Serum Biochemical Parameters and Oxidative Status of Broiler Chicks Exposed to Endosulfan in the Diets.]]>108696Ashour, E.A., M. Alagawany, F.M. Reda and M.E. Abd El-Hack,2014Yucca schidigera extract to growing rabbit diets on growth performance, carcass characteristics, serum biochemistry and liver oxidative status.]]>9732742Baker-Austin, C., M.S. Wright, R. Stepanauskas and J.V. McArthur,200614176182Guilhelmelli, F., N. Vilela, P. Albuquerque, L.D.S. Derengowski, I. Silva-Pereira and C.M. Kyaw,20132013Zaib ur Rehman and M.T. Munir,201533239Durrani, F.R., N. Chand, M. Jan, A. Sultan, Z. Durrani and S. Akhtar,200824655659Zeb-Ansari, J., A.H. Yousaf, T.M. Ahmad and S. Khan,200824323329Biu, A.A., S.D. Yusufu and J.S. Rabo,2009Azadirachta indica A. Juss) on haematological parameters in chicken.]]>10189192Nidaullah, H., F.R. Durrani, S. Ahmad, I.U. Jan and S. Gul,201055359Saeed, M., A.R. Baloch, M. Wang, R.N. Soomro and A.M. Baloch et al.,2015Cichorium intybus leaf extract as growth promoter, hepatoprotectant and immune modulent in broilers.]]>5585591Azeem, T., U.S. Zaib-Ur-Rehman, M. Asif, M. Arif and A. Rahman,2014Nigella sativa on poultry health and production: A review.]]>27682Li, Y., J. Yao, C. Han, J. Yang and M.T. Chaudhry et al.,20162016Genta, S.B., W.M. Cabrera, A. Grau and S.S. Sanchez,2005Smallanthus sonchifolius (yacon) roots as a diet supplement in rats.]]>4316571665Genta, S., W. Cabrera, N. Habib, J. Pons, I.M. Carillo, A. Grau and S. Sanchez,200928182187Ojansivu, I., C.L. Ferreira and S. Salminen,2011224046Lobo, A.R., C. Colli, E.P. Alvares and T.M.C.C. Filisetti,2007Smallanthus sonchifolius Poepp & Endl.) flour on caecum mucosal morphometry, calcium and magnesium balance, and bone calcium retention in growing rats.]]>97776785Lobo, A.R., C. Colli and T.M.C.C. Filisetti,200626413420Saulnier, D.M., J.K. Spinler, G.R. Gibson and J. Versalovic,200920135141Cashman, K.D.,20071372507S2512SKim, Y.J.,2013Polymnia sonchifolia) by-products on performance and physico-chemical properties of chicken thigh meat.]]>4019Lomax, A.R. and P.C. Calder,20091514281518Gonzales, G.F., C. Gonzales-Castaneda and M. Gasco,201323509518Kim, Y.J.,2014416168Satoh, H., M.A. Nguyen, A. Kudoh and T. Watanabe,2013Smallanthus sonchifolius, Asteraceae) improves hepatic insulin resistance via reducing Trb3 expression in Zucker fa/fa rats.]]>2013Scheid, M.M.A., P.S. Genaro, Y.M.F. Moreno and G.M. Pastore,20145314571464Lachman, J., E.C. Fernandez and M. Orsak,2003Smallanthus sonchifolia (Poepp. et Endl.) H. Robinson) chemical composition and use-a review.]]>49283290Zardini, E.,1991Polymnia sonchifolia (Asteraceae).]]>457285Manrique, I., M. Hermann and T. Bernet,20042004Hermann, M., I. Freire and C. Pazos,19991999Santana, I.C. and M. Helena,2008Smallanthus sonchifolius): Potencialidade de cultivo, aspectos tecnologicos e nutricionais.]]>38898905Vasconcelos, C.M., C.O.D. Silva, L.J.Q. Teixeira, J.B.P. Chaves and H.S.D. Martino,2010Smallanthus sonchifolius) root and flour by enzymatic-gravimetric method and high pressure liquid chromatography].]]>69188193Roberfroid, M.B.,200593S13S25Yıldız, S.,2010271650Vilhena, S.M.C., F.L.A. Camara and S.T. Kakihara,20001858Prati, P., A.S. Berbari, M.T.B. Pacheco, M.G. Silva and N. Nacazume,200912285294Hondo, M., A. Nakano, Y. Okumura and T. Yamaki,200047148154Da Rosa, C.S., V.R. de Oliveira, V.B. Viera, C. Gressler and S. Viega,20093918691872FAO.,20072007Magalhaes, M.S., S. Salminen, C.L.L.F. Ferreira and J. Tommola,20112011Geyer, M., I. Manrique, L. Degen and C. Beglinger,2008Smallanthus sonchifolius) on colonic transit time in healthy volunteers.]]>783033Li, Y., J. Mills, L.H. Jacobson, M. Manley-Harris, G.J. le Roux and R.G. Bell,20105399108Gibson, G.R.,200842S75S79Samanta, A.K., S. Senani, A.P. Kolte, M. Sridhar, K.T. Sampath, N. Jayapal and A. Devi,2012in vitro evaluation of xylooligosaccharides generated from corn cobs.]]>90466474Park, C.I. and Y.J. Kim,2013Polymnia sonchifolia) by-products and pine needle powder on growth performance and meat quality of chicken thigh meat.]]>40187195Bibas Bonet, M.E., O. Meson, A. de Moreno de LeBlanc, C.A. Dogi and S. Chaves et al.,2010Smallanthus sonchifolius) on intestinal mucosa using a mouse model.]]>21175189Van der Wielen, P.W., S. Biesterveld, L.J. Lipman and F. van Knapen,2001Salmonella enterica serovar Enteritidis by volatile fatty acids representative of the ceca of broiler chickens.]]>6719791982Miyaguchi, Y., T. Tomatsuri, A. Toyoda, E. Inoue and Y. Ogawa,2015Smallanthus sonchifolius)-derived fructooligosaccharides on the intestinal flora and immune system of OVA-sensitized BALB/c mice.]]>21255262Campos, D., I. Betalleluz-Pallardel, R. Chirinos, A. Aguilar-Galvez, G. Noratto and R. Pedreschi,2012Smallanthus sonchifolius Poepp. & Endl), a source of fructooligosaccharides and phenolic compounds with antioxidant activity.]]>13515921599Bai, J., T. Suo, X. Wei, P. Dou and X. Ran et al.,2017137482Habib, N.C., S.M. Honore, S.B. Genta and S.S. Sanchez,2011Smallanthus sonchifolius (yacon) roots on diabetic rats: Biochemical approach.]]>1943139Roselino, M.N., N.D. Pauly-Silveira, D.C. Cavallini, L.S. Celiberto, R.A. Pinto, R.C. Vendramini and E.A. Rossi,20122012Delgado, G.T.C., R. Thome, D.L. Gabriel, W.M.S.C. Tamashiro and G.M. Pastore,2012Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mouse.]]>32884892Da Silva Almeida, A.P., C.M. Avi, L.F. Barbisan, N.A. de Moura, B.F.R. Caetano, G.R. Romualdo and K. Sivieri,2015Smallanthus sonchifolius) and Lactobacillus acidophilus CRL 1014 reduce the early phases of colon carcinogenesis in male Wistar rats.]]>744854Valentova, K., D. Stejskal, J. Bartek, S. Dvorackova, V. Kren, J. Ulrichova and V. Simanek,2008Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: In vivo safety assessment.]]>4610061013Sabater-Molina, M., E. Larque, F. Torrella and S. Zamora,200965315328Sun, Y. and M.X.D. O'Riordan,20138593118Yun, E.Y., H.S. Kim, Y.E. Kim, M.K. Kang and J.E. Ma et al.,20102149152