International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2017.109.121Al-BasherGadh AjaremJamaan S. AllamAhmed A. MahmoudAyman M. 22017132Objective: Perinatal nicotine exposure induces malformations and imbalances the prooxidant/antioxidant status. The present study aimed to investigate the possible protective effects of green tea extract against perinatal nicotine-induced alterations in mice newborns. Materials and Methods: Pregnant mice received 0.25 mg k1 nicotine on gestational day 12 to postnatal day 15. A control group received an equal volume of saline. Both control and nicotine exposed mice received 50 mg k1 green tea on gestational day 1 to postnatal day 15. Results: Mice born to nicotine-exposed dams showed significantly decreased body weight at days 10, 15 and 20 after birth. 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