International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2016.74.80AmrAbd El-Galil E OmarMohamed A. Al- AbdallaMohamed M. 22016122A series of synthesized 2,6-bis(tetracarboxamide)-pyridine and macrocyclic tripeptide derivatives 1-6 were previously prepared and screened as antimicrobial, anti-inflammatory and anticancer agents. The compounds for evaluation of analgesic, anticonvulsant and antiparkinsonian activities were used. Analgesic activities of selected compounds determined by hot plate assay, all tested compounds showed this property. Anticonvulsant activities of selected compounds measured their abilities to antagonize yohimbine-induced clonic seizure, all tested compounds showed this property. The antiparkinsonian activity measured by the ability of compounds to protect animals against the parkinsonian like signs induced by agonists, all tested compounds showed this property. All tested compounds showed analgesic, antipakinsonian and anticonvulsant activities and the order for these activities were 5b, 6a, 3, 5a, 5c, 4, 6c, 2, 6b and 1.]]>Abd El-Latif, N.A., A.E.G.E. Amr and A.A. Ibrahiem,2007138559567Abdel Salam, O.I., M.A. Al-Omar, N.M. Khalifa, A.E.G.E. Amr and M.M. Abdallah,201368264268Abo-Ghalia, M. and A. Amr,2004Nα-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity.]]>26283289Al-Salahi, R.A., M.A. Al-Omar and A.E.G.E. Amr,20101565886597Amr, A.G.E.,200560990998Amr, A.E.G.E., A.M. Mohamed and A.A. Ibrahim,200358861868Amr, A.G.E., A.M. Mohamed, S.F. Mohamed, N.A. Abdel-Hafez and A.E.F.G. Hammam,20061454815488Amr, A.E.G.E., H.H. Sayed and M.M. Abdalla,2005338433440Amr, A.E.G.E., M. Abo-Ghalia and M.M. Abdalah,20066113351345Amr, A.E., M.I. Hegab, A.A. Ibrahim and M.M. Abdalah,200313413951409Amr, A.E., O.I. Abdel-Salam, A. Attia and I. Stibor,199964288298Austen, K.F. and W.E. Brocklehurst,1961113521539Bekhit, A.A. and H.T.Y. Fahmy,2003H-pyrazolyl-oxazolidines or 1H-pyrazolyl-thiazolidines as anti-inflammatory-antimicrobial agents.]]>336111118Dunn, R.W. and S. Fielding,198710177188Gajavelli, S., D.A. Castellanos, O. Furmanski, P.C. Schiller and J. Sagen,200817445455Holla, B.S., B. Kalluraya, K.R. Sridhar, E. Drake, L.M. Thomas, K.K. Bhandary and M.J. Levine,1994b]-1,3,4-thiadiazines.]]>29301308Abd El-Salam, O.I., M.A. Al-Omar and A.E.G.E. Amr,20129406412Sahu, J.K., S. Ganguly and A. Kaushik,2014b][1,3,4] thiadiazine derivatives.]]>59095Khayyat, S. and A.E.G. Amr,2014α-dinicotinoyl)-bis-L-leucyl linear and macrocyclic peptides.]]>191069810716Lee, H.K., L. Zhang, M.D. Smith, A. Walewska and N.A. Vellore et al.,20152015Litchfield, Jr. J.T. and F. Wilcoxon,19499699113Nigade, G., P. Chavan and M. Deodhar,2012212737Nishitani, S., T. Matsumura, S. Fujitani, I. Sonaka, Y. Miura and K. Yagasaki,2002299693696Nishitani, S., C. Ijichi, K. Takehana, S. Fujitani and I. Sonaka,2004313387389Shandra, A.A., L.S. Godlevskii, A.M. Mazarati and R.F. Makul'kin,1989107211214Thirumurugan, P., S. Mahalaxmi and P.T. Perumal,2010122819832Tjolsen, A., J.H. Rosland, O.G. Berge and K. Hole,199125241250Tyahr, M.D.,1976Pages: 293Pages: 293Verma, M., M. Tripathi, A.K. Saxena and K. Shanker,199429941946Zhou, T., R.C. Hider, P. Jenner, B. Campbell, C.J. Hobbs and S. Rose et al.,20132352795282