International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2016.262.271TiwariRuchi KarthikKumaragurubaran RanaRajneesh Singh MalikYashpal DhamaKuldeep JoshiSunil Kumar 32016123Microbial activity is considered as an important cause for the manifestation of food spoilage. The detection of chemical signals sharing information between food spoilage bacteria present in food products has initiated a new dimension to formulate an alternate preventive strategy against these spoilage bacteria. Quorum sensing or cell-to-cell communication is employed by a diverse group of bacteria talking to each other through the signaling autoinducer molecules. Based on potential of these molecules, Quorum-Sensing Inhibitors (QSI) or Quorum Quenching (QQ) compounds can be used as novel biopreservatives which abrupt the virulence of food spoilage microbes to uphold the nutritional quality of packaged and Ready To Eat (RTE) food and food by products. Through the pharmaceutical interventions and molecular mechanisms of intracellular, intercellular and interspecies communication via signaling molecules, preventive strategies can be formulated for production of pathogen free food products. Though identification of species specific signaling pathways is a challenging task for the food microbiologists and pharamacists but proper implementation of QSI molecules would be helpful for the food manufacturers in food processing plants through critical follow ups of Hazard Analysis and Critical Control Point (HACCP) to maintain the food quality and sound public health. This review draws the attention of researchers involved in dairy microbiology, meat and fish processing industries, packaging channels and neutraceuticals and pharmaceutical industries to explore the library of QS and QSI molecules to put forward and apply them as bio-preservatives for production of safe food products to meet the global food demands of growing world population.]]>Whitehead, N.A., A.M.L. Barnard, H. Slater, N.J.L. Simpson and G.P.C. Salmond,200125365404Williams, P.,200715339233938Williams, P., K. Winzer, W.C. Chan and M. Camara,200736211191134Winson, M.K., S. Swift, L. Fish, J.P. Throup and F. Jorgensen et al.,1998163185192Xavier, K.B. and B.L. Bassler,20036191197Yang, L., M.T. Rybtke, T.H. Jakobsen, M. Hentzer, T. Bjarnsholt, M. Givskov and T. Tolker-Nielsen,2009Pseudomonas aeruginosa quorum-sensing inhibitors.]]>5324322443Yarwood, J.M. and P.M. Schlievert,2003Staphylococcus infections.]]>11216201625Zhang, L.H. and Y.H. Dong,20045315631571Zhou, L., H. Zheng, Y. Tang, W. Yu and Q. Gong,201335631637Zorriehzahra, M.J., S.T. Delshad, M. Adel, R. Tiwari, K. Karthik, K. Dhama and C.C. Lazado,20162016Dhama, K., S.K. Khurana, K. Karthik, R. Tiwari, Y.P.S. Malik and R.S. Chauhan,201416111Dhama, K., K. Karthik, R. Tiwari, M.Z. Shabbir, S. Barbuddhe, S.V.S. Malik and R.K. Singh,201535211235Dhama, K., Y.S. Malik, K. Karthik, R. Tiwari and S. Chakraborty,2015644042Dhama, K., M. Saminathan, S.S. Jacob, M. Singh and K. Karthik et al.,201511253290Dong, Y.H., X.F. Zhang, L.H.M. Soo, E.P. Greenberg and L.H. Zhang,2005Pseudomonas aeruginosa.]]>5612871301Dong, Y.H., L.H. Wang and L.H. Zhang,200736212011211Dunstall, G., M.T. Rowe, G.B. Wisdom and D. Kilpatrick,2005Pseudomonas spp. of raw milk origin.]]>72276280Flodgaard, L.R., P. Dalgaard, J.B. Andersen, K.F. Nielsen, M. Givskov and L. Gram,2005Photobacterium phosphoreum produce the cell-to-cell communication signal N-(3-hydroxyoctanoyl)homoserine lactone.]]>7121132120Fuqua, C., M.R. Parsek and E.P. Greenberg,200135439468Barrios, A.F.G., R. Zuo, Y. Hashimoto, L. Yang, W.E. Bentley and T.K. Wood,2006Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022).]]>188305316Gopu, V., S. Kothandapani and P.H. Shetty,2015Syzygium cumini (L.) Skeels and its anthocyanin malvidin against Klebsiella pneumoniae.]]>796169Gopu, V. and P.H. Shetty,20162016Hammer, B.K. and B.L. Bassler,2003Vibrio cholerae.]]>50101114Hoang, H.H., A. Becker and J.E. Gonzalez,2004Sinorhizobium meliloti gene expression.]]>18654605472Huang, J.J., J.I. Han, L.H. Zhang and J.R. Leadbetter,2003Pseudomonas aeruginosa PAO1.]]>6959415949Johnson, M.R., C.I. Montero, S.B. Conners, K.R. Shockley, S.L. Bridger and R.M. Kelly,2005Thermotoga maritima.]]>55664674Khan, M.S.A., M. Zahin, S. Hasan, F.M. Husain and I. Ahmad,200949354360Kumar, N.V., P.S. Murthy, J.R. Manjunatha and B.K. Bettadaiah,201415451457Liao, C.H., J. Sullivan, J. Gardy and L.J.C. Wong,1997831016Abraham, S.V.P.I., A. Palani, B.R. Ramaswamy, K.P. Shunmugiah and V.R. Arumugam,2011Capparis spinosa.]]>42658668Ammor, M.S., C. Michaelidis and G.J.E. Nychas,20087115101525Annous, B.A., P.M. Fratamico and J.L. Smith,200974R24R37Asad, S. and S.M. Opal,20082008Bai, A.J. and V.R. Rai,201110183193Bai, A.J. and R.R. Vittal,2014in vivo efficacy in food systems.]]>28269292Bottomley, M.J., E. Muraglia, R. Bazzo and A. Carfi,2007Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer.]]>2821359213600Brackman, G., T. Defoirdt, C. Miyamoto, P. Bossier, S. van Calenbergh, H. Nelis and T. Coenye,2008Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR.]]>2008Brooks, J.D. and S.H. Flint,20084321632176Choo, J.H., Y. Rukayadi and J.K. Hwang,200642637641Christensen, A.B., K. Riedel, L. Eberl, L.R. Flodgaard, S. Molin, L. Gram and M. Givskov,2003Serratia proteamaculans B5a.]]>149471483Czajkowski, R. and S. Jafra,200956116Dhama, K., M. Mahendran, S. Tomar and R.S. Chauhan,20089112Dhama, K., S. Rajagunalan, S. Chakraborty, A.K. Verma, A. Kumar, R. Tiwari and S. Kapoor,20131610761085Dhama, K., S. Chakraborty, S. Kapoor, R. Tiwari and A. Kumar et al.,20131513Dhama, K., S. Chakraborty, Mahima, M.Y. Wani and A.K. Verma et al.,201316101111Dhama, K., S. Chakraborty, R. Tiwari, A.K. Verma and M. Saminathan et al.,20144353370Dhama, K., R. Tiwari, S. Chakraborty, M. Saminathan and A. Kumar et al.,201410143Paggi, R.A., C.B. Martone, C. Fuqua and R.E. de Castro,2003Natronococcus occultus.]]>2214952Parker, C.T. and V. Sperandio,200911363369Podbielski, A. and B. Kreikemeyer,200488195Rahman, M.R.T., Z. Lou, F. Yu, P. Wang and H. Wang,2015Amomum tsaoko (Amommum tsao-ko Crevost et Lemarie) on foodborne pathogens.]]>2015Rasch, M., C. Buch, B. Austin, W.J. Slierendrecht and K.S. Ekmann et al.,2004Oncorhynchus mykiss, Walbaum).]]>27350359Rasmussen, T.B., T. Bjarnsholt, M.E. Skindersoe, M. Hentzer and P. Kristoffersen et al.,200518717991814Rivas, M., M. Seeger, E. Jedlicki and D.S. Holmes,2007Acidithiobacillus ferrooxidans.]]>7332253231Sarabhai, S., P. Sharma and N. Capalash,2013Terminalia chebula Retz. downregulate the expression of quorum sensing genes to attenuate Pseudomonas aeruginosa PAO1 virulence.]]>2013Schauder, S., K. Shokat, M.G. Surette and B.L. Bassler,200141463476Schuster, M., M.L. Urbanowski and E.P. Greenberg,2004Pseudomonas aeruginosa quorum sensing revealed by DNA binding of purified LasR.]]>1011583315839Skandamis, P.N. and G.J.E. Nychas,20127854735482Smith, J.L., P.M. Fratamico and J.S. Novak,20046710531070Steindler, L. and V. Venturi,2007N-acyl homoserine lactone signal molecules by bacterial biosensors.]]>26619Taga, M.E., J.L. Semmelhack and B.L. Bassler,2001Salmonella typhimurium.]]>42777793Tan, J.Y., W.F. Yin and K.G. Chan,2014Hafnia alvei isolated from packed food.]]>1467886796Tiwari, R. and K. Dhama,20149174176Tiwari, R., H.D. Kumar, T. Dutt, B.P. Singh, K. Pachaiyappan and K. Dhama,20149367384Tiwari, R., K. Dhama, S. Chakraborty, A. Kumar, A. Rahal and S. Kapoor,201417301315Truchado, P., J.A. Gimenez-Bastida, M. Larrosa, I. Castro-Ibanez and J.C. Espin et al.,2012Yersinia enterocolitica by an orange extract rich in glycosylated flavanones.]]>6088858894Limsuwan, S. and S.P. Voravuthikunchai,2008Boesenbergia pandurata (Roxb.) Schltr., Eleutherine americana Merr. and Rhodomyrtus tomentosa (Aiton) Hassk. as antibiofilm producing and antiquorum sensing in Streptococcus pyogenes.]]>53429436Llamas, I., E. Quesada, M.J. Martinez-Canovas, M. Gronquist, A. Eberhard and J.E. Gonzalez,2005N-acyl-homoserine lactones in the exopolysaccharide-producing species of Halomonas.]]>9333341Lynch, S.V. and J.P. Wiener-Kronish,200814593599El-Mowafy, S.A., K.H.A. El Galil, S.M. El-Messery and M.I. Shaaban,2014Pseudomonas aeruginosa.]]>742532Nealson, K.H., T. Platt and J.W. Hastings, 1970104313322Novick, R.P.,20034814291449Nychas, G.J.E., D.L. Marshall and J.N. Sofos,20072007pp: 105-140pp: 105-140Novak, J.S.,20062006pp: 55-65pp: 55-65Turovskiy, Y., D. Kashtanov, B. Paskhover and M.L. Chikindas,200762191234Van Houdt, R., A. Aertsen, A. Jansen, A.L. Quintana and C.W. Michiels,200496177184Van Houdt, R., P. Moons, A. Aertsen, A. Jansen and K. Vanoirbeek et al.,2007luxI/luxR-type quorum sensing system and N-acyl-homoserine lactone-dependent regulation of exo-enzyme and antibacterial component production in Serratia plymuthica RVH1.]]>158150158Brango-Vanegas, J., G.M. Costa, C.F. Ortmann, E.P. Schenkel and F.H. Reginatto et al.,2014Cecropia pachystachya Trecul are quorum sensing inhibitors.]]>21670675Vattem, D.A., K. Mihalik, S.H. Crixell and R.J.C. McLean,200778302310Viana, E.S., M.E.M. Campos, A.R. Ponce, H.C. Mantovani and M.C.D. Vanetti,2009Hafnia alvei isolated from raw milk.]]>42427436Vikram, A., G.K. Jayaprakasha, P.R. Jesudhasan, S.D. Pillai and B.S. Patil,2010109515527Vivas, J., D. Padilla, F. Real, J. Bravo, V. Grasso and F. Acosta,2010Hafnia alvei strains.]]>129150155Waters, C.M. and B.L. Bassler,200521319346Whitfield, F.B., N. Jensen and K.J. Shaw,2000Pseudomonas putida in the development of a fruity off-flavour in pasteurized milk.]]>67561569Fuqua, W.C. and S.C. Winans,1994Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumor metabolite.]]>17627962806