International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2015.821.827In vitro Antibacterial and in vivo Brine Shrimp Lethal Active Compounds Isolated from the Leaves of Saurauia roxburghii]]>AhmedYunus YaakobZahira AkhtarParul RahmanMahbubur IslamFaridul 72015117Seven triterpenoids namely, ursolic acid (1) cis-3-O-p-hydroxycinnamoyl ursolic acid (2), trans-3-O-p-hydroxycinnamoyl ursolic acid (3), oleanolic acid (4), corosolic acid (5), maslinic acid (6) and β-amyrin (7) were isolated from the leaves of Saurauia roxburghii based on spectroscopic indication. Compounds 2, 3 and 4 were isolated from this plant for the first time. The LC50 for crude ethanol, n-hexane, chloroform, ethyl-acetate; column fractions H-13 of the crude n-hexane, C-19 of the crude chloroform and three pure compounds 1, 3 and 4 were found to be 12.59, 14.79, 14.06, 11.75, 10.96, 4.37, 6.92 and 11.88 μg mL1, respectively. The crude ethanol extract exhibited good; n-hexane, chloroform, ethyl-acetate extracts exhibited moderate; five column fractions (H-13, C-15, C-19, E-18 and E-24) exhibited low to mild and three pure compounds (1, 3 and 4) presented moderate antibacterial activity against maximum of the tested bacteria.]]>Ahmed, Y., S. Rahman, P. Akther and F. Islam,2013Saurauia roxburghii.]]>2029392943Barry, A.,19911991pp: 1-16pp: 1-16Bauer, A.W., W.M.M. Kirby, J.C. Sherris and M. Turck,196645493496Bhakuni, D.S., M. Bittner, C. Marticorena, M. Silva, E. Weldt, M.E. Melo and R. Zemelman,197437621632Bhatt, B.,2011Solanum xanthocarpum.]]>3176181Chowdhury, M.A.U., M.A. Rahman, M. Zahan, M.H. Sohrab, C.M.M. Hasan and Y. Ahmed,2012Saurauja roxburghii.]]>2418251830Falodun, A., A.M.A. Chaudhry and I.M. Choudhary,200931317Farnsworth, N.R., O. Akerele, A.S. Bingel, D.D. Soejarto and Z. Guo,198563965981Frighetto, R.T.S., R.M. Welendorf, E.N. Nigro, N. Frighetto and A.C. Siani,2008106767771Huang, Y., D. Nikolic, S. Pendland, B.J. Doyle, T.D. Locklear and G.B. Mahady,2009Escherichia coli, COX-2 activity, pro-inflammatory cytokine release and the NF-κβ transcriptional response in vitro.]]>471825Jahan, N., A. Malik, G. Mustafa, Z. Ahmad and S. Ahmad et al.,2001Mimusops elengi.]]>15177185Kojima, H. and H. Ogura,1986Prunella vulgaris.]]>25729733Kojima, H. and H. Ogura,19892817031710Kondo, M., S.L. MacKinnon, C.C. Craft, M.D. Matchett, R.A. Hurta and C.C. Neto,2011Vaccinium fruit and effects on matrix metalloproteinase activity in DU145 prostate tumor cells.]]>91789796Lee, S.H., H.S. Lillehoj, H.K. Chun, W. Tuo and H.J. Park et al.,2007In vitro treatment of chicken peripheral blood lymphocytes, macrophages and tumor cells with extracts of Korean medicinal plants.]]>27362366Lin, C.N., M.I. Chung, K.H. Gan and J.R. Chiang,19872823812384Mazumder, K., E.R.O. Siwu, S. Nozaki, Y. Watanabe, K. Tanaka and K. Fukase,2011Saurauja roxburghii: Isolation and cytotoxic activity against a431 and c6 glioma cell lines.]]>4287291McLaughlin, J.L., L.L. Rogers and J.E. Anderson,199832513524Meyer, B.N., N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols and J.L. McLaughlin,1982453134Murphy, B.T., S.L. MacKinnon, X. Yan, G.B. Hammond, A.J. Vaisberg and C.C. Neto,2003in vitro antitumor activity from whole cranberry fruit (Vaccinium macrocarpon).]]>5135413545Newman, D.J. and G.M. Cragg,200770461477Noel, M.G. and F.M. Dayrit,2005Vitex negundo L.]]>134519Ozgen, U., A. Mavi, Z. Terzi, C. Kazaz, A. Asci, Y. Kaya and H. Secen,2011Thymus sipyleus subsp. sipyleus var. sipyleus.]]>51221Rahman, M.A., S.B. Uddin and C.C. Wilcock,2007Chakma tribe in Hill Tracts districts of Bangladesh.]]>6508517Rizwana, N., I. Nazlina, M.A.R. Razehar, A.Z.S. Noraziah and C.Y. Ling, et al.,20104203210Sang, S., K. Lapsley, R.T. Rosen and C.T. Ho,2001Prunus amygdalus batsch).]]>50607609Uddin, S.N.,2006Pages: 992Pages: 992Seebacher, W., N. Simic, R. Weis, R. Saf and O. Kunert,20031H and 13C NMR resonances of oleanolic acid, 18α-oleanolic acid, ursolic acid and their 11-oxo derivatives.]]>41636638Stevigny, C., C. Bailly and J. Quetin-Leclercq,20055173182Sundaram, S., S.K. Verma and P. Dwivedi,201142729Taketa, A.T.C., E. Breitmaier and E.P. Schenkel,2004Ilex paraguariensis (Mate).]]>15205211Yasue, M., J. Sakakibara and H. Ina,1973Tripetaleia paniculata Sieb. et Zucc. 3. On the constituents of the wood].]]>93687691, (In Japanese)Bernhoft, A., H. Siem, E. Bjertness, M. Meltzer and T. Flaten et al.,2010Pages: 255Pages: 255Ahmed, Y., M.H. Sohrab, S.M. Al-Reza, F.S. Tareq, C.M. Hasan and M.A. Sattar,2010Sapium baccatum.]]>48549552