International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2015.72.75Foeniculum vulgare Extract in Streptozocin-Induced Diabetes in Rats]]>MhaidatNizar M. Abu-zaitonAhmed S. AlzoubiKarem H. AlzoubiWael AlazabRami S. 12015111The present study aimed to evaluate the antihyperglycemic effects of Foeniculum
vulgare extract in streptozotocin (STZ)-induced diabetes in rats. Diabetes
was induced via an intraperitoneal injection of STZ (50 mg kg‾1
b.wt.). Control and diabetic animals were treated by F. vulgare extract
(100 mg kg‾1) or a similar volume of vehicle. Animals body
weight and water intake were monitored and recorded. Blood glucose, amylase,
total cholesterol alanine aminotransferase (ALT), aspartate aminotransferase
(AST), urea and creatinine were determined using standard biochemical methods.
Results indicated that treatment of diabetic animals with F. vulgare
extract restored body weight to be similar to control animals. Additionally,
treatment with F. vulgare reduced hyperglycemia in diabetic animals,
yet it did not affect glucose levels in control animals. Similarly, treatment
of diabetic animals with F. vulgare significantly reduced the diabetes-associated
elevation in levels of amylase, total cholesterol, ALT, AST, urea and creatinine
suggesting a protective effect on the cardiovascular system, the liver and kidneys.
These findings demonstrated the effectiveness of F. vulgare extract in
management of STZ-induced diabetes and some of its related complications in
animal models. Thus, a more comprehensive characterization of the medicinal
potential of F. vulgare will provide understanding of its mechanisms
of action and its possible use for diabetes.]]>El-Soud, N., N. El-Laithy, G. El-Saeed, M. Wahby, M. Khalil, F. Morsy and N. Shaffie,2011Foeniculum vulgare Mill. essential oil in streptozotocin-induced diabetic rats.]]>4139146Al-Shamaony, L., S.M. Al-Khazraji and H.A.A. Twaiji,1994Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals.]]>43167171Albert-Puleo, M.,19802337344Alzoubi, K.H., O.F. Khabour, I.A. Alhaidar, A.M. Aleisa and K.A. Alkadhi,201351763770Barros, L., S.A. Heleno, A.M. Carvalho and I.C. Ferreira,2009Foeniculumvulgare Mill. from Portugal.]]>4724582464Baytop, T.,19841984Boodhwani, M. and F.W. Sellke,20091119451959Dadalioglu, I. and G.A. Evrendilek,2004Origanum minutiflorum), bay laurel (Laurus nobilis), spanish lavender (Lavandula stoechas L.) and fennel (Foeniculum vulgare) on common foodborne pathogens.]]>5282558260Dongare, V., C. Kulkarni, M. Kondawar, C. Magdum, V. Haldavnekar and A. Arvindekar,2012Foeniculum vulgare Mill. fruits.]]>132385390Jang, Y.Y., J.H. Song, Y.K. Shin, E.S. Han and C.S. Lee,200042361371Kalra, S.,201363277280Kramer, C.K. and R. Retnakaran,201327301302Loew, D. and M. Kaszkin,200216705711Maiese, K., Z.Z. Chong, Y.C. Shang and J. Hou,201151128152Maiese, K., Z.Z. Chong, Y.C. Shang and S. Wang,201383548McCue, P., D. Vattem and K. Shetty,2004in vitro.]]>13401408Mehta, A.K., N. Arora, S.N. Gaur and B.P. Singh,200954282286Mimica-Dukic, N., S. Kujundzic, M. Sokovic and M. Couladis,2003Foeniculum vulgare Mill. obtained by different distillation conditions.]]>17368371Mohamad, R.H., A.M. El-Bastawesy, M.G. Abdel-Monem, A.M. Noor, H.A. Al-Mehdar, S.M. Sharawy and M.M. El-Merzabani,2011149891001Ostad, S.N., M. Soodi, M. Shariffzadeh, N. Khorshidi and H. Marzban,200176299304Pari, L.J. and J. Umamaheswari,2000Musa sapientum flowers: Effect on lipid peroxidation in alloxan diabetic rats.]]>14136138Sarkhail, P., S. Rahmanipour, S. Fadyevatan, A. Mohammadirad and G. Dehghan et al.,2007Phlomis anisodonta: Effects on hepatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.]]>56261266Schone, F., A. Vetter, H. Hartung, H. Bergmann and A. Biertumpfel et al.,2006Foeniculi aetheroleum) and caraway (Carvi aetheroleum) in pigs.]]>90500510Spasov, A.A., V.I. Petrov, N.I. Chepliaeva and K.V. Lenskaia,201324349, (In Russian)Stadler, K.,2012771272287Tognolini, M., V. Ballabeni, S. Bertoni, R. Bruni, M. Impicciatore and E. Barocelli,2007Foeniculum vulgare essential oil and anethole in an experimental model of thrombosis.]]>56254260Wolff, S.P.,199349642652