International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2015.523.531Heteropterys Genus: A Review of its Phytochemistry and Pharmacology]]>Huerta-ReyesMaira Fonseca JuarezRosa Maria Aguilar-RojasArturo 62015116Heteropterys is the largest genus in the botanical family Malpighiaceae that comprises more than 140 species. In the last years there has been an increasing interest on Heteropterys species because of the promising results of the pharmacological studies that explored Heteropterys species for first time. The objective of this review is to provide an overview of the active constituents isolated from Heteropterys genus, highlighting the aspects reported on the diversity of the biological activities tested during the past years. For this purpose, we reviewed the scientific literature available for the total number of species that belong to Heteropterys in specialized databases. Our findings showed that the properties on CNS (anxiolytic, antidepressant, improving learning and memory), the antioxidant effects and the protective activities of reproductive male organs are the most important biological activities reported for species of Heteropterys. Flavonoids are the chemicals most conspicuous, following by aliphatic nitro compounds and hydroxycinnamic acids identified in Heteropterys. This review pretend to be helpful for phytochemists and pharmacologist in the proposal of Heteropterys as potential source of metabolites that could be used to drug prototypes to many and diverse pathological or physiological situations.]]>Agripino, D., M.E.L. Lima, M.R. da Silva, C.I. Meda and V. da Silva et al.,20044115Anderson, W.R., C. Anderson and C.C. Davis,20062006Araujo, J.S., A.A. Azevedo, L.C. Silva and R.M.S.A. Meira,2010286117131Bennett, B.C. and M.J. Balick,2014152387392Bezerra, A.G., S.S. Smaili, G.S. Lopes and E.A. 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Carlini,2002Heteropterys aphrodisiaca (extract BST0298): A Brazilian plant that improves memory in aged rats.]]>79305311Galvao, S.M.P., F.R. Mendes, M.G.M. Oliveira, R. Mattei, J.C.P. de Mello, W.A. Roman Jr. and E.A. Carlini,2011Heteropterys aphrodisiaca in aging rats.]]>47825832Gomes, M.L.M., J.C. Monteiro, K.M. Freitas, M.M. Sbervelheri and H. Dolder,2011Heteropterys aphrodisiaca and endurance training brings spermatogenetic advantages.]]>44235241Guilhon-Simplicio, F. and M.M. Pereira,2011Byrsonima (Malpighiaceae).]]>3410321041Heywood, V.H.,20072nd Edn.,Pages: 424Pages: 424Huerta-Reyes, M., M. Herrera-Ruiz, M. Gonzalez-Cortazar, A. Zamilpa and E. Leon et al.,2013in vivo effects and phytochemical profile of the extract from the aerial parts of Heteropterys brachiata (L.) DC. (Malpighiaceae).]]>146311317Huerta-Reyes, M., A. Zamilpa, R. Alvarez-Chimal, J.A. Luna-Manzanares and M.E. 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Machado: Effects of extract BST0298 on the oxidative stress of young and old rat brains.]]>15604607McKenna, D.J., G.H. Towers and F. Abbott,198410195223Meeuse, A.D.J.,1986Melo, F.L., F.J. Benati, W.A. Roman Jr., J.C.P. de Mello, C. Nozawa and R.E.C. Linhares,2008in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca.]]>163136139Monteiro, J.C., F.S. Predes, S.L.P. Matta and H. Dolder,2008Heteropterys aphrodisiaca infusion reduces the collateral effects of cyclosporine a on the testis.]]>291809817Monteiro, J.C., M.L.M. Gomes, T.C. Tomiosso, W.R. Nakagaki and M.M. Sbervelheri et al.,2011Heteropterys aphrodisiaca and endurance training.]]>2011Nunes, R.S., V.F.S. Kahl, M.S. Sarmento, M.F. Richter and J.A. Abin-Carriquiry et al.,2013Malpighia glabra L.) extract in relation to the geographic origin.]]>2714951501Paula-Freire, L.I.G., F.R. Mendes, G.R. Molska, J.M. Duarte-Almeida and E.A. Carlini,2013Heteropterys tomentosa A. Juss.]]>145647652Rivera, D., R. 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