International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2015.43.49Trigonella foenum-graecum
L.) On Selected Biochemical and Oxidative Stress Biomarkers in Rats Intoxicated
with Carbon Tetrachloride]]>Al-SultanS.I. El-BahrS.M. 12015111The objective of the current study was to investigate the protective effects of
aqueous extract of fenugreek (Trigonella foenum-graecum
L.) against carbon tetrachloride (CCl4), induced hepatotoxicity in
rats. Therefore, twenty rats were fed standard diet and divided into four groups.
Rats in the first and second groups were injected i/p with paraffin oil and received
either tap water (control 1) or aqueous extract of fenugreek (control 2), respectively.
Rats in the third and fourth groups were injected i/p with CCl4 and
received either tap water or aqueous extract of fenugreek, respectively. At the
end of the experiment (5 weeks), blood and liver samples were collected. Sera
were used for selected biochIical analysis and liver tissues were used for estimation
of selected oxidative stress biomarkers. The present findings revealed that, CCl4
elevated serum transaminases, hepatic lipid peroxidation and hepatic enzymatic
antioxidants activities. Oral fenugreek aqueous extract ameliorated the detrimental
effects of CCl4 and corrected all examined biomarkers toward the control
values. The present study concluded that aqueous extract of fenugreek plays a
protective role against CCl4-induced liver damages in rats. These protective
effects were in the form of improvIent of serum transaminases, attenuation of
hepatic lipid peroxidation and activation of hepatic antioxidant enzymes.]]>Al-Fartosi, K.G., A. Majid, M.A. Auda and M.H. Hussein,20124.]]>3385389Al-Habori, M., A.M. Al-Aghbari and M. Al-Mamary,199812572575Al-Habori, M. and A. Raman,199812233242Althnaian, T., I., Albokhadaim and S.M. El-Bahr,20132013Anuradha, C.V. and P. Ravikumar,2001Trigonella foenum graecum) in alloxan-diabetic rats.]]>45408420Aranda, M., C.D. Albendea, F. Lostale, L. Lopez-Pingarron and L. Fuentes-Broto et al.,2010In vivo hepatic oxidative stress because of carbon tetrachloride toxicity: Protection by melatonin and pinoline.]]>497885Arici, O.F. and N. Cetin,20114)-induced coagulation disturbances in rats.]]>166139142Awal, M.A., M.U. Rashid, K.W. Ahmedm, Z.S. Asadi and K. Islam,19991568Belguith-Hadriche, O., M. Bouaziz, K. Jamoussi, A. El Feki, S. Sayadi and F. Makni-Ayedi,20105821162122Blumenthal, M., W.R. Busse, A. Goldberg, J. Gruenwald and T. Hall et al.,1998pp: 118-130pp: 118-130Bona, S., L.I. Filippin, F.C. Di Naso, C. de David and B. Valiatti et al.,20122012Brent, J.A. and B.H. Rumack,199331173196Chatterjee, S., P.S. Variyar and A. Sharma,20095792269233Cruz, C., M.E. Ibarra-Rubio and J. Pedraza-Chaverri,1993208388Das, S.,2014Fenugreek seeds on rats.]]>515061513Yousef, M.I.,20041994757Zimmerman, H.J., Y. Kodera and M. West,196566324333Devasena, T. and V. Menon,20026289292Eidi, A., M. Eidi and M. Sokhteh,2007Trigonella foenum-graecum L.) seeds on serum parameters in normal and streptozotocin-induced diabetic rats.]]>27728733El-Bahr, S.M.,201493040Elmahdi, B., S.M. El-Bahr and A.M. Abdelghany,2014Trigonella foenum-graecum L.) on selected biochemical parameters of rats fed high cholesterol diet: Profiles of lipid and lipoproteins.]]>158399420Fahim, F.A., A.Y. Esmat, H.H. Fadel and K.F.S. Hassan,1999Rosmarinus officinalis L. on experimental hepatotoxicity and mutagenesis.]]>50413427Havel, R.J.,198648119134Jahn, C.E., E.J. Schaefer, L.A. Taam, J.H. Hoofnagle and F.T. Lindgren et al.,19858912661278Jensen, R.,1992123Khalil, E.A.M.,2004Trigonella foenum graecum) on alloxan diabetic male rats.]]>158394Khan, A.A. and M.A. Alzohairy,20114-induced hepatotoxicity in rats.]]>6171180Lee, C.H., S.W. Park, Y.S. Kim, S.S. Kang, J.A. Kim, S.H. Lee and S.M. Lee,20073018981904Mion, F., A. Geloen, E. Agosto and Y. Minaire,199623582588Muller, P., R. Fellin, J. Lambrecht, B. Agostini, H. Wieland, W. Rost and D. Seidel,19744419428Muralidhara, K. Narasimhamurthy, S. Viswanatha and B.S. Ramesh,199937831838Muriel, P., N. Alba, V.M. Perez-Alvarez, M. Shibayama and V.K. Tsutsumi,2001130219226Noor, E.A.,200832330Ogeturk, M., I. Kus, A. Kavakli, I. Zararsiz, N. Ilhan and M. Sarsilmaz,200460205210Palanivel, M.G., B. Rajkapoor, R.S. Kumar, J.W. Einstein and E.P. Kumar et al.,2008Pisonia aculeata L. against CCl4-induced hepatic damage in rats.]]>76203215Palaparthy, R., H. Kastrissios and A. Gulati,200153179185Park, W.H., S.K. Lee and C.H. Kim,2005Panax notoginseng, prevents liver fibrosis and hepatic microvascular dysfunction in rats.]]>7616751690Pirinccioglu, M., G. Kizil, M. Kizil, G. Ozdemir, Z. Kanay and M.A. Ketani,2012Vitis vinifera L. cv.) grape juice against carbon tetrachloride induced oxidative stress in rats.]]>3668673Puri, D., K.M. Prabhu and P.S. Murthy,200246457462Recknagel, R.O., E.A. Glende, Jr., J.A. Dolak and R.L. Waller,198943139154Romero-Alvira, D. and E. Roche,199646414420Sakr, S.A. and S.M. Abo-El-Yazid,201228876885SAS.,2002Sharma, R.D.,1984T. foemun graecum) an experimental study in rats.]]>30221231Sharma, R.D.,1986T. foenum graecum) in rats.]]>33669677Shrivastava, R., S.S. Solanki, V. Tomar, N. Garud, A. Garud, P. Kannojia and N. Jain,20091912Stoyanovsky, D.A. and A.I. Cederbaum,199912730736Thabrew, M., P.D.T.M. Joice and W. Rajatissa,1987Pavetta indica and Osbeckia octandra in the treatment of liver dysfunction.]]>53239241Thirunavukkarasu, V., C.V. Anuradha and P. Viswanathan,2003Trigonella foenum graecum) seeds in experimental ethanol toxicity.]]>17737743Wang, G.R., W.Z. Tang, Q.Q. Yao, H. Zhong and Y.J. Liu,2010Trigonella foenum-graecum L.]]>64358361Wirth, K.J., M. Bickel, M. Hropot, V. Gunzler, H. Heitsch, D. Ruppert and B.A. Scholkens,19972 receptor antagonist icatibant (HOE 140) corrects avid Na+ retention in rats with CCl4-induced liver cirrhosis: Possible role of enhanced microvascular leakage.]]>3374553Junnila, M., T. Rahko, A. Sukura and L.A. Lindberg,200037231238