International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2015.359.365+ in the Carbon Tetrachloride (CCl4) Induced Chronic Liver Dysfunction in Rat Model]]>SafariManouchehr GhahariLaya SafariKatayoun MadadianMahmoodreza AldaghiMohammad Reza ZarbakhshSam 42015114Regenerative medicine using bone marrow cells is noteworthy therapy for the improvement of patients with severe liver disease. Bone marrow stem cells can participate to liver regeneration. However, conflicting results have been reported. Twenty five, 12 week old albino-wistar male rats were randomly assigned into five groups. In treatment groups CD133+ cells in both differentiated and non-differentiated form were transplanted in rat models of CCl4-induced chronic liver dysfunction. All rats were killed 4 weeks after transplantation. Transplantation of the differentiated and non differentiated hematopoietic stem cells into the blood of rats significantly restored their serum albumin level. These effects were not seen in CCl4 rats. However, fibrotic liver lesions with severe inflammation were decreased in CCl4-treated following hematopoietic stem cells transplantation. Effective migration of transplanted hematopoietic stem cells was limited to persistently injured liver in CCl4-treated rat, where they may be effective in resolving inflammatory fibrotic lesions. These results suggest that differentiated Hematopoietic stem cells are an effective cell source for liver regeneration.]]>Abdel Aziz, M.T., H.M. Atta, S. Mahfouz, H.H. Fouad and N.K. Roshdy et al.,200740893899Alison, M.R., R. Poulsom, R. Jeffery, A.P. Dhillon and A. Quaglia et al.,2000406257257Baram, D., G.G. Vaday, P. Salamon, I. Drucker, R. Hershkoviz and Y.A. Mekori,200116740084016Bataller, R. and D.A. Brenner,2005115209218Caplan, A.I.,19919641650Dominici, M., K. le Blanc, I. Mueller, I. Slaper-Cortenbach and F. Marini et al.,20068315317Fang, B., M. Shi, L. Liao, S. Yang, Y. Liu and R.C. Zhao,2004+ mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice.]]>158388Friedman, S.L.,200888125172Heissig, B., Y. Ohki, Y. Sato, S. Rafii, Z. Werb and K. Hattori,200510247253Kollet, O., S. Shivtiel, Y.Q. Chen, J. Suriawinata and S.N. Thung et al.,2003+ stem cell recruitment to the liver.]]>112160169Korbling, M., R.L. Katz, A. Khanna, A.C. Ruifrok and G. Rondon et al.,2002346738746Lai, C.L., V. Ratziu, M.F. Yuen and T. Poynard,200336220892094Lee, K.D., T.K.C. Kuo, J. Whang-Peng, Y.F. Chung and C.T. Lin et al.,2004In vitro hepatic differentiation of human mesenchymal stem cells.]]>4012751284Li, Y., J. Chen, X.G. Chen, L. Wang and S.C. Gautam et al.,200259514523Neo, S., T. Ishikawa, K. Ogiwara, N. Kansaku and M. Nakamura et al.,20098716Okamoto, R., T. Yajima, M. Yamazaki, T. Kanai and M. Mukai et al.,2002810111017Petersen, B.E., W.C. Bowen, K.D. Patrene, W.M. Mars and A.K. Sullivan et al.,199928411681170Piscaglia, A.C., C. di Campli, G. Gasbarrini and A. Gasbarrini,200335507514Piscaglia, A.C., T. Shupe and A. Gasbarrini,20038167175Pittenger, M.F., A.M. Mackay, S.C. Beck, R.K. Jaiswal and R. Douglas et al.,1999284143147Poldervaart, J.H., R.P. Favier, L.C. Penning, T.S.G.A.M. van den Ingh and J. Rothuizen,2009237280Poynard, T., M.F. Yuen, V. Ratziu and C.L. Lai,200336220952100Rabani, V., M. Shahsavani, M. Gharavi, A. Piryaei, Z. Azhdari and H. Baharvand,201034601605Ratajczak, M.Z., M. Kucia, R. Reca, M. Majka, A. Janowska-Wieczorek and J. Ratajczak,2004182940Sakaida, I., S. Terai, N. Yamamoto, K. Aoyama, T. Ishikawa, H. Nishina and K. Okita,20044-induced liver fibrosis in mice.]]>4013041311Terai, S., T. Ishikawa, K. Omori, K. Aoyama and Y. Marumoto et al.,20062422922298Theise, N.D., M. Nimmakayalu, R. Gardner, P.B. Illei and G. Morgan et al.,2000321116Trim, N., S. Morgan, M. Evans, R. Issa and D. Fine et al.,200015612351243Wang, P.P., J.H. Wang, Z.P. Yan, M.Y. Hu and G.K. Lau et al.,2004320712716Zheng, J.F. and L.J. Liang,20087264270Zocco, M.A., A.C. Piscaglia, F. Giuliante, V. Arena and M. Novi et al.,2011+ stem cell mobilization after partial hepatectomy depends on resection extent and underlying disease.]]>43147154