International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2015.226.235BerredjemH. ReggamiY. BenlaifaM. BerredjemM. BouzernaN. 32015113The present study aimed to investigate the effects of the 3, 4-dihydroisoquinolin-2(1H)-sulfonamide on blood glucose, lipid profile, hepatic and renal functions and enzyme activities in alloxan-induced diabetic Wistar rats. Experimental diabetes was produced by a single intraperitoneal injection of alloxan (140 mg kg-1 b.wt.). Three groups of diabetic rats were administered orally with two doses of the novel sulfonamide (2.5 and 5 mg kg-1 b.wt.) and a standard drug, glibenclamide (2.5 mg kg-1 b.wt.), for 10 days. Changes in body weight, food consumption, water intake and blood glucose levels were recorded regularly. At the end of the treatment period, blood was collected to determine biochemical parameters and enzyme activities in serum samples. Pancreas, liver, kidneys, spleen and heart were weighed in order to evaluate the relative organ weight. Histological changes in pancreas were examined by microscopy according to procedure with hematoxylin-eosin. The treatment with 2.5 and 5 mg kg-1 of the tested compound decreased the pathophysiological disturbances of diabetic syndrome. A significant (p<0.001) anti-hyperglycemic activity was clearly observed from the 4th day. Significant decreases (p<0.05) in total lipid and total cholesterol levels and highly significant decreases (p<0.001) in the level of Triglyceride were also noted with the two doses of the tested compound. Moreover, renal and hepatic functions were improved and lesions of pancreas were reversed in treated animals. However, the tested compound at 5 mg kg-1 produced highly significant increase (p<0.001) in the relative spleen weight. Our findings suggest that the 3, 4-dihydroisoquinolin-2(1H)-sulfonamide is endowed with an interesting anti-diabetic activity comparable to glibenclamide; however, it could present an immunological risk, so further more studies must be undertaken.]]>Akhtar, A., M. Rashid, M.I. Ibne Wahed, M.R. Islam and S.M. Shaheen et al.,2007Coccinia cordifolia (Linn.) and Catharanthus roseus (Linn.) in Alloxan-induced diabetic rats.]]>22934Almdal, T.P. and H. Vilstrup,198831114118American Diabetes Association,200932S62S67Annamala, P.T. and K.T. Augusti,198036383384Al-Shamaony, L., S.M. Al-Khazraji and H.A.A. Twaiji,1994Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals.]]>43167171Anwar, M.M. and A.R.M.A. Meki,2003135539547Balakumar, P., V.A. Chakkarwar, V. Kumar, A. Jain, J. Reddy and M. Singh,20089189195Bopanna, K.N., J. Kanna, G. Sushma, R. Balaraman and S.P. Rathod,199729162172Bouasla, R., M. Berredjem, S. Hessainia, Z. Chereait, H. Berredjem and N.E. Aouf,2011511531159Brownlee, M.,2001414813820Chen, L., D.J. Magliano and P.Z. Zimmet,20128228236Chisolm, G.M., K.C. Irwin and M.S. Penn,1992416166Dehghan, A., M. Van Hoek, E.J.G. Sijbrands, A. Hofman and J.C.M. Witteman,200831361362Del Prato, S. and N. Pulizzi,2006552027Deng, Y.G., Z.S. Zhao, M. Wang, S.O. Su and X.X. Yao,20061250915093El-Demerdash, F.M., M.I. Yousef and N.I.A. El-Naga,2005435763Evan, A.P., S.A. Mong, B.A. Connors, G.R. Aronoff and F.C. Luft,19842083347Fawcett, J.K. and J.E. Scott,196013156159Green, J.B. and M.N. Feinglos,20066373377Gupta, M.P., N.G. Solis, M. Esposito and S. Sanchez,1984Neurolaena lobata (L.) R. Br.]]>10323327Hamden, K., S. Carreau, K. Jamoussi, S. Miladi, S. Lajmi, D. Aloulou, F. Ayadi and A. Elfeki,200955215222Howard, B.V., P.J. Savage, L.J. Bennion and P.H. Bennett,197830153162Jefferson, L.S., W.S.L. Liao, D.E. Peavy, T.B. Miller, M.C. Appel and J.M. Taylor,198325813691375Joy, K.L. and R. Kuttan,1999Picrorrhiza kurroa extract.]]>67143148Kang, J., X.S. Dai, T.B. Yu, B. Wen and Z.W. Yang,200542110116Kechrid, Z. and N. Bouzerna,2004111418Kim, J.S., B.B. Ju, C.W. Choi and S.C. Kim,20062154160Lenzen, S.,200851216226Madianov, I.V., M.I. Balabolkin, D.S. Markov and T.N. Markova,2002725558, (In Russian)Mansour, H.A., A.S.A. Newairy, M.I. Yousef and S.A. Sheweita,2002170221228Maren, T.H.,197616309327Mauer, S.M., M.W. Steffes and D.M. Brown,198170603612Modan, M., H. Halkin, A. Karasik and A. Lusky,198730713718Nathan, D.M., J.B. Buse, M.B. Davidson, E. Ferrannini and R.R. Holman et al.,200932193203Navarro, C.M., P.M. Montilla, A. Martin, J. Jimenez and P.M. Utrilla,1993Rosmarinus tomentosus.]]>59312314Odetola, A.A., O. Akinloye, C. Egunjobi, W.A. Adekunle and A.O. Ayoola,2006Parkia biglobosa (JACQ) extract in alloxan-induced diabetic rats.]]>33808812Prentki, M. and C.J. Nolan,200611618021812Pupim, L.B., O. Heimburger, A.R. Qureshi, T.A. Ikizler and P. Stenvinkel,20056823682374Rajasekaran, S., K. Ravi, K. Sivagnanam and S. Subramanian,2006Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes.]]>33232237Rana, S.V., R. Singh and S. Verma,199634177179Saravanan, G. and L. Pari,20035156162Saravanan, G. and P. Ponmurugan,201264639644Schrijvers, B.F., A. De Vriese and A. Flyvbjerg,2004259711010Scozzafava, A., T. Owa, A. Mastrolorenzo and C.T. Supuran,200310925953Shaw, J.E., R.A. Sicree and P.Z. Zimmet,201087414Smith, D.A. and R.M. Jones,2008117279Tragl, K.H. and G.M. Reaven,1972218488Udayakumar, R., S. Kasthurirengan, T.S. Mariashibu, M. Rajesh and V.R. Anbazhagan et al.,2009Withania somnifera root and leaf extracts on alloxan-induced diabetic rats.]]>1023672382Virdi, J., S. Sivakami, S. Shahani, A.C. Suthar, M.M. Banavalikar and M.K. Biyani,2003Momordica charantia.]]>88107111Wool, I.G., O.R. Rampersad and A.N. Moyer,196640716720Wun, Y.T., C.S. Chan and C.S. Lui,199912286291Yassin, M.M., A.R.A. Ashour and N.R. Elyazji,200412P37P54