International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2014.90.108SaeidniaSoodabeh AbdollahiMohammad 22014102Cancer occurs when alterations of genetic material create
an abnormal function leading to unregulated proliferation of cells in the body.
Cancer remains as one of the most predominant illnesses causing death, where
each year more than 10 million people are identified worldwide. Due to restrictions
and side effects observed from various chemotherapeutic anti-cancer drugs, as
well as thousands of secondary metabolites formed in plants and other natural
organisms, there is a high trend, toward novel drug discovery from natural sources.
It seems that high throughput screenings based on reverse pharmacology and reverse
pharmacognosy might result in more successful approaches in the future. The
main objective of this review is to exhibit an up-to-date comprehensive overview
on the recently identified natural antitumor compounds from various natural
origins including plants, fungi, endophytic fungi and marine organisms. In order
to facilitate the anticancer drug discovery and development, new strategies
might be considered such as biotechnology and nanoparticle targeting approaches.
The reverse pharmacognosy and its complementary the reverse pharmacology which
are associated with high throughput screening, virtual screening and knowledge
databases from traditional medicine, provide successful and strong tools to
accelerate the process of future drug discovery.]]>Abdollahi, M. and S.V. Shetab-Boushehri,20122012Akihisa, T., Y. Nakamura, M. Tagata, H. Tokuda and K. Yasukawa et al.,2007Ganoderma lucidum.]]>4224231Akramiene, D., A. Kondrotas, J. Didziapetriene and E. Kevelaitis,200643597606Alawadi, S., L. Ghabreau, M. Alsaleh, Z. Abdulaziz, M. Rafeek, N. Akil and M. Alkhalaf,201128709715Alderton, G.K. and Y. Bordon,201212237237Anand, P., A.B. Kunnumakkara, R.A. Newman and B.B. Aggarwal,20074807818Anand, P., S.G. Thomas, A.B. Kunnumakkara, C. Sundaram and K.B. Harikumar et al.,20087615901611Antony, B., B. Merina, V.S. Iyer, N. Judy, K. Lennertz and S. Joyal,2008TM), a novel bioenhanced preparation of curcumin.]]>70445449Bagchi, D. and H.G. Preuss,2005pp: 665pp: 665Bahadar, H., S. Mostafalou and M. Abdollahi,20142768394Bar-Sela, G., R. Epelbaum and M. Schaffer,201017190197Baur, J.A. and D.A. Sinclair,2006in vivo evidence.]]>5493506Blanpain, C.,201315126134Berthold, D.R., G.R. Pond, M. 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