International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2014.345.356MirfazaelianHadi NikfarShekoufeh SalarianAmir-Ahmad AbdollahiMohammad 72014107The present study is a meta-analysis on clinical trials evaluating
the efficacy of oximes on organophosphorus (OP) intoxication treatment. PubMed,
Scopus, Google Scholar and clinicaltrials.gov were searched for studies investigating
the effects of oximes in the treatment of OP poisoning. Mortality, intermediate
syndrome, Intensive Care Unit (ICU) admission rate, hospital stay duration and
intubation rate were the key outcomes of interest. Data were searched in the
time period of 1966 through April 2014. Thirteen studies (eleven clinical trials
and two historical cohorts) that met our criteria were included in the analysis.
Pooling of data showed that Relative Risk (RR) of need for intubation in OP
poisoning for ten included trials comparing oximes with placebo was 1.18 with
95% CI = 0.76 to 1.84 (p = 0.27). RR of the single observational study was 1.57
(95% CI = 0.79 to 3.2, p>0.05). The summary of RR for mortality rate in 11
studies was 1.4 (95% CI = 0.77 to 2.54, p = 0.41) and for two observational
studies was 1.19 (95% CI = 0.5 to 2.85, p>0.05). The RR for ICU admission
rate in OP poisoning for three trials comparing oximes to placebo was 2.12 with
95% CI = 0.89 to 5.03 (p = 0.09). For the single observational study, RR was
0.81 (95% CI = 0.49 to 1.25, p>0.05). For intermediate syndrome while the
RR of only trial comparing oximes with placebo was 1.89 (95% CI = 1.27 to 2.91,
p<0.05), for the single observational study, it was 1.43 (95% CI = 0.7 to
2.96, p>0.05). For hospital stay duration (difference), the RR of four studies
was 0.75 with 95% CI = -0.51 to 1.99. According to these data, oximes beneficence
in OP poisoning is unclear and there is a potential increase in the incidence
of intermediate syndrome.]]>Abdollahi, M., A. Jafari, N. Jalali, M. Balali, A. Kebriaeezadeh and S. Nikfar,1995Afzali, S.,2002Balali-Mood, M. and M. Shariat,1998Baloch, G.H., A.H. Khan, C. Madhudas, B.R. Devrajani, S.Z.A. Shah, T. Dos and S.A. Shah,2011Banerjee, I., S.K. Tripathi and A.S. Roy,2014Banerjee, I., S.K. Tripathi and A.S. Roy,2011Bertolote, J.M., A. Fleischmann, A. Butchart and N. Besbelli,2006Buckley, N.A., M. Eddleston, Y. Li, M. Bevan and J. Robertson,2011Chaudhary, S.C., K. Singh, K.K. Sawlani, N. Jain and A.K. Vaish et al.,2013Cherian, A.M., J.V. Peter, S. Johnson, R. Jaydevan and S. Peter et al.,1997Cherian, M.A., C. Roshini, J. Visalakshi, L. Jeyaseelan and A.M. Cherian,2005Chugh, S.N., N. Aggarwal, S. Dabla and B. Chhabra,2005De Silva, H.J., R. Wijewickrema and N. Senanayake,1992Duval, G., J.M. Rakouer, D. Tillant, J.C. Auffray, J. Nigond and G. Deluvallee,1990Eddleston, M., P. Eyer, F. Worek, E. Juszczak and N. Alder et al.,2009Eddleston, M., L. Szinicz, P. Eyer and N. Buckley,2002Ellman, G.L., K.D. Courtney, V. Andres Jr. and R.M. Featherstone,1961Eyer, P.,2003Farrar, H.C., T.G. Wells and G.L. Kearns,1990Gunnell, D., R. Fernando, M. Hewagama, W.D.D. Priyangika, F. Konradsen and M. Eddleston,2007Jadad, A.R.,1998Johnson, M.K., D. Jacobsen, T.J. Meredith, P. Eyer and A.J. Heath et al.,2000Johnson, M.K., J.A. Vale, T.C. Marrs and T.J. Meredith,1992Johnson, S., J.V. Peter, K. Thomas, L. Jeyaseelan and A.M. Cherian,1996Karami-Mohajeri, S., S. Nikfar and M. Abdollahi,2014Kwong, T.C.,2002Mirfazaelian, H., S. Nikfar, M.A. Rezvanfar and M. Abdollahi,2014Namba, T., C.T. Nolte, G. Jackrel and D. Grob,1971Peter, J.V., J.L. Moran and P. Graham,2006Peter, J.V., J.L. Moran, K. Pichamuthu and B. Chacko,2008Rahimi, R., S. Nikfar and M. Abdollahi,2006Raja, V., A.R. Simon and P. Udaykumar,2013Shivakumar, S., K. Raghavan, R.M. Ishaq and S. Geetha,2006Sungur, M. and M. Guven,2001Wilson, I.B. and S. Ginsburg,1955Worek, F., M. Backer, H. Thiermann, L. Szinicz, U. Mast, R. Klimmek and P. Eyer,1997Worek, F., C. Diepold and P. Eyer,1999Worek, F., P. Eyer and L. Szinicz,1998Mostafalou, S. and M. Abdollahi,2013