International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2014.231.236WanLiping WangChun LiuLin TangXiaoqiong WangJinghua GuanYue JiangMing DuanXianlin KeXiaoyan JingHongmei HuJiong WangLing LiYuming GengLi 42014104Invasive Fungal Disease (IFD) is a major cause of death in severe neutropenic patients with hematologic malignancies. Micafungin, a new echinocandin antifungal drug, is effective in treating IFD. However, the efficacy and safety of micafungin in preventing IFD in severe neutropenic patients with hematologic malignancies have not been demonstrated. A prospective and multicenter clinical study was conducted to evaluate the efficacy and safety of micafungin as prophylaxis for IFD. Micafungin 50 mg daily was administered intravenously to 117 high-risk patients with hematologic malignancies undergoing intensive chemotherapy or Hematopoietic Stem Cell Transplantation (HSCT), for a median of 24 days. Successful prophylaxis (no proven, probable or possible IFD up to 1 week after the end of prophylactic treatment) was achieved in 88.54% patients. No patient developed proven IFD during treatment and only 2.08% had probable IFD and 9.38% possible IFD. Micafungin potentially accounted for adverse events in 6.84% of patients. No severe adverse events attributable to micafungin were seen. Micafungin 50 mg daily is a promising prophylactic antifungal therapy for neutropenic patients with hematologic malignancies.]]>Chandrasekar, P.H. and J.D. Sobel,20064211711178De Pauw, B., T.J. Walsh, J.P. Donnelly, D.A. Stevens and J.E. Edwards et al.,20084618131821Freifeld, A.G., E.J. Bow, K.A. Sepkowitz, M.J. Boeckh and J.I. Ito et al.,201152e56e93Fukuoka, N., O. Imataki, H. Ohnishi, A. Kitanaka, Y. Kubota, T. Ishida and T. Tanaka,20104227252730Goodman, J.L., D.J. Winston, R.A. Greenfield, P.H. Chandrasekar and B. Fox et al.,1992326845851Hirata, Y., T. Yokote, K. Kobayashi, S. Nakayama and S. Oka et al.,201051853859Huang, X., H. Chen, M. Han, P. Zou and D. Wu et al.,20121815091516Ikawa, K., K. Nomura, N. Morikawa, K. Ikeda and M. Taniwaki,2009Aspergillus infections.]]>64840844Inoue, Y., T. Saito, K. Ogawa, Y. Nishio and S. Kosugi et al.,201250831837Kurosawa, M., M. Yonezumi, S. Hashino, J. Tanaka and M. Nishio et al.,201296748757Malagola, M., A. Peli, D. Damiani, A. Candoni and M. Tiribelli et al.,200881354363Michallet, M. and J.I. Ito,20092733983409NCI,19991999Pagano, L., M. Caira, A. Candoni, M. Offidani and L. Fianchi et al.,20069110681075Pagano, L., M. Caira, A. Nosari, M.T. van Lint and A. Candoni et al.,20074511611170Pfaller, M.A., D.J. Diekema, D.L. Gibbs, V.A. Newell and D. Ellis et al.,201067162171Pfaller, M.A., D.J. Diekema, D.L. Gibbs, V.A. Newell and D. Ellis et al.,2010Candida species to fluconazole and voriconazole as determined by CLSI standardized disk diffusion.]]>4813661377Robenshtok, E., A. Gafter-Gvili, E. Goldberg, M. Weinberger, M. Yeshurun, L. Leibovici and M. Paul,20072554715489Scott, L.,20127221412165Van Burik, J.A.H., V. Ratanatharathorn, D.E. Stepan, C.B. Miller and J.H. Lipton et al.,20043914071416