International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2014.120.128LiuHuanzhong RenZhenhua ZhongJian CaiHan ChenXuequan LiJun 22014102Blockade of the NMDA receptor by the use of MK-801 during the early postnatal
period has been proposed to be an experimental model which induces behavioural
changes that mimic positive, negative and cognitive symptoms of schizophrenia.
We provide an overview of the effects of early life MK-801 administration on
body weight, locomotor activity and spatial memory and assessed the long term
behavioural profile arising from this early life manipulation. We found that
intraperitoneal administration of MK-801 (0.35 mg kg-1) twice a day
for 2 weeks in rat pups on postnatal days 7, showed a significant weight loss,
hypoactivity and the damage of spatial memory. The long term behavioural profile
showed that hypoactivity continuously reduced until 11 weeks after MK-801 administration
in animal model. But for spatial memory, a short term damage was observed in
model rats. After the treatment with clozapine or haloperidol, a recovery in
locomotor activity was observed in the rats of model group. However, there was
no effect on the spatial memory in model rat after drug treatment. The results
of the present study demonstrated that clozapine and haloperidol might reverse
a long lasting hypoactivity induced by repeated treatment with MK-801 in neonatal
rats but no effect on a short term damage of spatial memory.]]>Arif, M., M.M. Ahmed, Y. Kumabe, H. Hoshino, T. Chikuma and T. Kato,200649304311Baier, P.C., A. Blume, J. Koch, A. Marx, G. Fritzer, J.B. Aldenhoff and T. Schiffelholz,200920596101Beninger, R.J., A. Jhamandas, H. Aujla, I. Xue, R.V. Dagnone, R.J. Boegman and K. Jhamandas,20024477488Boess, F.G., M. Hendrix, F.J. van der Staay, C. Erb and R. Schreiber et al.,20044710811092Bradford, A.M., K.M. Savage, D.N. Jones and M. Kalinichev,2010212155170Brenner, E., D. Kondziella, A. Haberg and U. Sonnewald,20059415941603Csernansky, J.G., M. Martin, R. Shah, A. Bertchume, J. Colvin and H. Dong,20053021352143Enomoto, T., T. Ishibashi, K. Tokuda, T. Ishiyama, S. Toma and A. Ito,2008186197207Eyjolfsson, E.M., E. Brenner, D. Kondziella and U. Sonnewald,200648541546Glahn, D.C., S. Therman, M. Manninen, M. Huttunen, J. Kaprio, J. Lonnqvist and T.D. Cannon,200353624626Gorter, J.A. and R.J. Brady,19946656368Green, M.F., K.H. Nuechterlein, J.M. Gold, D.M. Barch and J. Cohen et al.,200456301307Gururajan, A., D.A. Taylor and D.T. Malone,201099131138Haberny, K.A., M.G. Paule, A.C. Scallet, F.D. Sistare, D.S. Lester, J.P. Hanig and W. Slikker Jr.,200268917Hargreaves, E.L. and D.P. Cain,1992N-methyl-d-aspartate non-competitive channel blocker MK801.]]>472333Harvey, P.D., M.F. Green, R.S. Keefe and D.I. Velligan,200465361372Ishiyama, T., K. Tokuda, T. Ishibashi, A. Ito, S. Toma and Y. Ohno,2007572160170Kato, T.A., A. Monji, Y. Mizoguchi, S. Hashioka and H. Horikawa et al.,201111565574Kawabe, K., T. Iwasaki and Y. Ichitani,2007N-methyl-d-aspartate antagonists in neonatal, but not adult, rats causes long-term deficits of radial-arm maze learning.]]>11697786Kawabe, K. and E. Miyamoto,200819969973Kocahan, S., K. Akillioglu, S. Binokay, L. Sencar and S. Polat,201338989996Kondziella, D., E. Brenner, E.M. Eyjolfsson, K.R. Markinhuhta, M.L. Carlsson and U. Sonnewald,20063118801887Latysheva, N.V. and K.S. Rayevsky,2003N-methyl-d-aspartate receptor blockade induces learning deficits and transient hypoactivity in young rats.]]>27787794Lyall, A., J. Swanson, C. Liu, T.D. Blumenthal and C.P. Turner,2009197215222Manahan-Vaughan, D., D. von Haebler, C. Winter, G. Juckel and U. Heinemann,200818125134McLamb, R.L., L.R. Williams, K.P. Nanry, W.A. Wilson and H.A. Tilson,1990374145Mouri, A., Y. Noda, T. Enomoto and T. Nabeshima,200751173184Pearlson, G.D.,200048556566Pryce, C., A. Mohammed and J. Feldon,20027315Reynolds, L.M., S.M. Cochran, B.J. Morris, J.A. Pratt and G.P. Reynolds,2005N-acetylaspartate and N-acetylaspartylglutamate in rat brain.]]>73147152Riedel, G., B. Platt and J. Micheau,2003140147Rung, J.P., A. Carlsson, K.R. Markinhuhta and M.L. Carlsson,200529827832Schiffelholz, T., D. Hinze-Selch and J.B. Aldenhoff,2004360157160Stefani, M.R. and B. Moghaddam,200557433436Su, Y.A., X.D. Wang, J.T. Li, C.M. Guo and Y. Feng et al.,201122402406Theberge, J., R. Bartha, D.J. Drost, R.S. Menon and A. Malla et al.,200215919441946Uehara, T., T. Sumiyoshi, T. Seo, H. Itoh, T. Matsuoka, M. Suzuki and M. Kurachi,2009206623630Viberg, H., W. Mundy and P. Eriksson,200829152159Vigano, D., C. Guidali, S. Petrosino, N. Realini, T. Rubino, V. Di Marzo and D. Parolaro,200912599614Wong, E.H., J.A. Kemp, T. Priestley, A.R. Knight, G.N. Woodruff and L.L. Iversen,19868371047108