International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2013.335.347Candida albicans by Streptomyces sp. NEAE-1]]>El-Ahmady El-NaggarNoura A. El-BindaryAshraf Salah NourNoura 6201396The production of antimicrobial agent by Streptomyces sp. NEAE-1 in shake flask culture was optimized using response surface methodology. Initial screening of production parameters was performed using a Plackett-Burman design and the variables with statistically significant effects on antimicrobial agent production were identified. Out of the fifteen factors screened, KNO3, NaCl and inoculum size were selected due to significant positive effect on the production of antimicrobial agent. The optimal levels of these variables and the effect of their mutual interactions on antimicrobial agent production were determined using Box-Behnken design. 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