International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2013.312.317Asparagus laricinus
]]>FukuSandile Al-AzzawiAmad M. Madamombe-MandunaIdah T. MasheleSamson 5201395This study reports on the phytochemistry and radical scavenging
activity of Asparagus laricinus Burch (Asparagaceae) in order to explain
the anti-cancer properties it possesses. The root extracts of Asparagus laricinus
were qualitatively screened for antioxidant properties using 2, 2-diphenyl-1-picrylhydrazyl
(DPPH), on silica gel GF254 TLC plates. Quantitative Radical scavenging
activity using DPPH was also evaluated. The extracts were tested for the presence
of alkaloids, saponins, tannins, terpenoids and steroids using standard phytochemical
screening methods. Gas chromatography/mass spectrometry (GC/MS) was used to
further confirm the phytoconstituents. Three spots that exhibited antioxidant
activity were resolved on the TLC plates. The free radical scavenging activity
of A. laricinus extract was comparable with that of Trolox7
and was dependent on the concentration of the extract. The aqueous extract of
A. laricinus contained alkaloids, saponins, tannins and terpenoids while
the ethanol and dichloromethane extracts produced negative results. The phytoconstituents
confirmed through the use of GC-MS were indole-3-carbinol, α-sitosterol
and ferulic acid. The phytochemicals present and the antioxidant activity demonstrated
by extracts of A. laricinus explain its in vitro anti-cancer properties
as well as its continued use in traditional medicine for the treatment of cancer
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