International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2013.305.311ZabetianHassan JahromiAbdolreza Sotoodeh KaramiMohammad Yasin GhobadifarMohamed Amin 5201395Shivering related to spinal anesthesia is a usual complication.
This study was designed to evaluate the anti-shivering effect of small intrathecal
dose of meperidine on the incidence and intensity of shivering in parturient
with caesarean section under spinal anesthesia. Seventy parturient, American
Society of Anesthesiologists (ASA) physical status I to II, scheduled for elective
caesarean section under spinal anesthesia were enrolled in two groups. The parturient
were randomized to receive 10 mg bupivacaine 0.5% and 10 mg meperidine (group
BM, n = 35) or placebo (10 mg bupivacaine 0.5% and normal saline, group B, n
= 35) 3 min after spinal puncture. Demographic values, surgery data, adverse
events and the mean intensity for each parturient were assessed during the whole
time of study period by a blinded observer. The incidence of shivering during
the whole time of the study period was significantly decreased in the group
of parturient who received intrathecal meperidine (p<0.001). There were no
significant differences in the other measured variables. These findings indicate
that using single-shot, mini-dose intrathecal Meperidine (10 mg) reduces the
severity and intensity of intra- and post-operative shivering in caesarean section
under spinal anesthesia without increasing adverse events.]]>Crowley, L.J. and D.J. Buggy,200833241252Chun, D.H., H.K. Kil, H.J. Kim, C. Park and K.H. Chung,201059389393Locks, G.F.,201262676684Khaw, K.S., W.D.N. Kee and S.W. Lee,200617157183Bhukal, I., S.L. Solanki, S. Kumar and A. Jain,201127349353Crossley, A.W.A.,199247193195Kranke, P., L.H. Eberhart, N. Roewer and M.R. Tramer,200294453460Kranke, P., L.H. Eberhart, N. Roewer and M.R. Tramer,200499718727Karaman, S., F. Akercan, T. Akarsu, V. Firat, O. Ozcan and N. Karadadas,20051211823Khan, Z.H., A.P. Zanjani, J. Makarem and S. Samadi,201128202206Fukuda, K.,20052005pp: 379-437pp: 379-437Casey, W.F., C.E. Smith, J.M. Katz, K. O'Loughlin and S.K. Weeks,198835128133Chen, J.C., S.W. Hsu, L.H. Hu, Y.J. Hong and P.S. Tsai et al.,1993311924Roy, J.D., M. Girard and P. Drolet,200498230234Hong, J.Y. and I.H. Lee,20056011681172Kararmaz, A., S. Kaya, S. Turhanoglu and M.A. Ozyilmaz,200358526530Crossley, A.W. and R.P. Mahajan,199449205207Bryant, B.J., B.J. Bryant, K.M. Knights, E. Salerno, Bryant, Knights and K.M. Knights,20113rd Edn.,pp: 252-264pp: 252-264Pang, W.W., M.S. Mok, S. Huang and M.H. Hwang,199886382386Nishikawa, K., N. Kanaya, M. Nakayama, M. Igarashi, K. Tsunoda and A. Namiki,200091384387Karakaya, D., F. Buyukgoz, S. Baris, F. Guldogus and A. Tur,200126434438Hu, L.H., J.C. Chen, Y. Lee, K.B. Lai, K.L. Wong and T.T. Wei,199230223228 [In Chinese]Nordberg, G., V. Hansdottir, U. Bondesson, L.O. Boreus, T. Mellstrand and T. Hedner,198834625631Freye, E.,1974534047Morisy, L. and D. Platt,1986255467468Kaiko, R.F., K.M. Foley, P.Y. Grabinski, G. Heidrich, A.G. Rogers, C.E. Inturrisi and M.M. Reidenberg,198313180185