International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2013.182.189Foeniculum vulgare" Treatment Protects the Gastric Mucosa
of Rats against Chemically-induced Histological Lesions]]>Al-MoflehIbrahim Al-SobaihaniMohamed AlqasoumiSaleh Al-SaidMansour Al-DosariMohammed Al-YahyaMohamed RafatullahSyed 3201393This study evaluated anti-gastric ulcer and anti-secretory
effects of folkloric medicinal plant, Foeniculum vulgare L., (Family:Apiaceae)
in rats. The gastric ulcer protective potential of an aqueous suspension of
'Fennel' Foeniculum vulgare (FVS) was evaluated against different acute
gastric ulcer models in rats induced by pyloric ligation (Shay), hypothermic
restraint stress, indomethacin and by necrotizing agents (80% ethanol, 0.2 M
NaOH and 25% NaCl). Fennel suspension, 250 and 500 mg kg-1 b.wt.
administered orally (intraperitoneally in Shay rat model) showed a dose-dependent
ulcer protective effects in all the above models. Besides, the FVS offered protection
against ethanol-induced depletion of Gastric Wall Mucus (GWM); replenished the
reduced nonprotein sulfhydryls (NP-SH) concentration and modulated malondialdehyde
(MDA) contents in the gastric tissue. Ethanol induced histopathological lesions
of the stomach wall characterized by mucosal hemorrhages and edema that was
reversed by FVS. Pretreatment of rats with FVS provided significant protection
of gastric mucosa through its antioxidant capacity and/or by attenuating the
offensive and by enhancing the defensive factor.]]>Abdul-Ghani, A.S. and R. Amin,1988Foeniculum vulgare leaves.]]>24213218Ageel, A.M., M.A. Al-Yahya, M. Tariq, S. Babhair, M.S. Al-Said, A. Khatibi and A. Angary,19871987Al-Harbi, M.M., S. Qureshi, M. Raza, M.M. Ahmed, A.B. Giangreco and A.H. Shah,1995Ehrlich ascites carcinoma cells in paw of Swiss albino mice.]]>4307318Baggio, C.H., C.S. Freitas, L. Rieck and M.C.A. Marques,2003Baccharis illinita DC in rats.]]>479398Bhargava, K.P., M. Dass, G.P. Gupta and M.B. Gupta,198068765772Bhargava, K.P., M.G. Gupta and K.K. Tanvir,197322191195Birdane, F.M., M. Cemek, Y.O. Birdane, I. Gulcin and M.E. Buyukokuroglu,200713607611Chiu, P.J.S., C. Gerhart, A.I. Brown and A. Barnett,198434783786Chomdler, R.F. and D. Hawkes,19841172829Corne, S.J., S.M. Morrissey and R.J. Woods,1974242116P117PCulling, C.F.A.,19743rd Edn.,pp: 73, 126, 159pp: 73, 126, 159File, S.E. and J.B. Pearce,198174593599Firulescu, S., S. Negres and D. Mihele,201058695702Garga, C., S.A. Khan, S.H. Ansari, A. Suman and M. Garg,2009Foeniculum vulgare.]]>3346352Ghanem, M.T.M., H.M.A. Radwan, E.S.M. Mahdy, Y.M. Elkholy, H.D. Hassanein and A.A. Shahat,2012Foeniculum vulgare (Subsp. Piperitum) (Apiaceae) herb and evaluation of hepatoprotective antioxidant activity.]]>4104108Goa, K.L. and J.P. Monk,19873539559Grieve, M.,1971Vol. 1,pp: 293-297pp: 293-297Guth, P.H.,197217807813Hara, N., Y. Hara, Y. Natsume and Y. Goto,19911947781Heim, H.K., A. Oestmann and K.F. Sewing,1991104526530Howden, C.W.,20041174448Kabiruddin, M.,19211921Kinoshita, Y., C. Kawanami, K. Kishi, H. Nakata, Y. Seino and T. Chiba,1997Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese.]]>41452458Kitagawa, H., M. Fjuwara and Y. Osumi,197977298302Koo, M.W.L., C.W. Ogle and C.H. Cho,198632326334Leung, Y.A.,1980pp: 409pp: 409Levine, R.J.,19711971pp: 92-97pp: 92-97Marotti, M., R. Piccaglia, E. Giovanellic, S.G. Deans and E. Eaglesham,1994Foeniculum vulgare Mill.).]]>65762Mascolo, N., G. Autore, F. Capasso, A. Menghini and M.P. Fasulo,198712831Newberne, P.M., W.W. Carlton and W.R. Brown,1989272126Odabasoglu, F., A. Cakir, H. Suleyman, A. Aslan, Y. Bayir, M. Halici and C. Kazaz,20061035965Rafatullah, S., M.A. Al-Yahya, M.S. Al-Said, K.U. Abdul Hameed Taragan and J.S. Mossa,199432163170Rainsford, K.D. and C. Willis,198227624635Repetto, M.G. and S.F. Llesuy,200235523534Robert, A., J.E. Nezamis, C. Lancaster, J.P. Daris, S.O. Field and A.J. Hanchar,1983245G113G121Shay, H., S.A. Komarow, S.S. Fels, D. Meranze, M. Gruenstein and H. Siplet,194554361Szabo, S., J.S. Trier and P.W. Frank,1981214200202Truhaut, R., B. Le Bourhis, M. Atlia, R. Glomot, J. Newman and J. Galdwell,1989271120Utley, H.G., F. Bernheim and P. Hochstein,19671182932Wallace, J.L. and B.J. Whittle,198691603611Wiseman, R.W., E.C. Miller, J.A. Miller and A. Liem,19874722752283Sedlak, J. and R.H. Lindsay,196825192205