International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2013.170.175SrisungS. SuksrichavalitT. PrachayasittikulS. RuchirawatS. PrachayasittikulV. 2201392Heterocyclic compounds like 8-hydroxyquinoline (8HQ) and derivatives
have been found in natural products and therapeutics. Herein 8HQ and metal complexes
of 8HQ-5-substituted (X) uracils, X = I, NO2 (1-6) were investigated
for their antimicrobial potency. The complexes 1-6 exhibited growth inhibition
against many strains of gram-positive and gram-negative bacteria with minimum
inhibitory concentrations (MICs) of 575.71-718.76 μM. The investigated
compound 8HQ was shown to be a very strong antimicrobial agent with the MIC
of 27.58 μM that comparable to ampicillin (MIC 26.93 μM), the reference
drug. The activity of 8HQ mostly was observed for resistant pathogens, gram-
positive bacteria e.g. Staphylococcus aureus, Enterococcus faecalis
and diploid fungus, Candida albicans. The findings reveal 8HQ as the
very potent antimicrobial agent and a series of 8HQ transition metal complexes
as novel antimicrobials as well as the applications of 8HQ for the design and
synthesis of new and potential therapeutic lead compounds.]]>Anjaneyulu, Y., R. Prabhakar Rao, R.Y. Swamy, A. Eknath and K. Narasimha Rao,19821982pp: 157163Colak, A., U. Terzi, M. Col, S.A. Karaoglu, S. Karabocek, A. Kucukdumlu, F.A. Ayaz,20104551695175Darby, C.M. and C.F. Nathan,2010Mycobacterium tuberculosis by 8-hydroxyquinoline.]]>6514241427Depalma, P.D., J.J. Loux, J. Hutchman, M.M. Dolan and S.L. Yankell,197655292298Diekema, D.J., M.A. Pfaller, F.J. Schmitz, J. Smayevsky, J. Bell, R.N. Jones and M. Beach,2001Staphylococcus species: Frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe and the Western pacific region for the SENTRY antimicrobial surveillance program, 1997-1999.]]>32S114S132Dixit, R.B., T.S. Patel, S.F. Vanparia, A.P. kunjadiya, H.R. Keharia and B.C. Dixit 201179309322Dutta, S., S. Padhye and V. McKee,2004710711074Galal S.A., K.H. Hegab, A.M. Hashem and N.S. Youssef,20104556855691Garcia-Fernandaz, A., L. Villa, C. Carta, C. Venditti and A. Giordano et al.,2012Klebsiella pneumonia ST258 producing KPC-3 identified in Italy carries novel plasmids and OmpK36/OmpK35 porin varients.]]>5621432145Hadda, T.B., M. Akkurt, M.F. Baba, M. Daoudi, B. Bennani, A. Kerbal and Z.H. Chohan,200924457463Ileperuma, O.A., R.C. Senarathna and M.M.M.C. Meedeniya,1989Broussonetia zeylanica (THW.) Corner.]]>17111115 Jeon, J.H., C.H. Lee and H.S. Lee,200952202205Kim, Y.H., K.J. Woo, J.H. Lim, S. Kim and T.J. Lee et al.,2005β in Raw 264.7 cells.]]>329591597Kostyuk, V.A., A.I. Potapovich, E.N. Strigunova, T.V. Kostyuk and I.B. Afanas'ev,2004428204208Lawung, R., L. Treeratanapiboon, S. Prachayasittikul and V. Prachayasittikul,2010Staphylococcus aureus.]]>7674678Liu, Y.J., C.H. Zeng, H.L. Huang, L.X. He and F.H. Wu,201045564571Mahal, H.S., S. Kapoor, A.K. Satpati and T. Mukherjee,20051092419724202Mayhall, C.G.,200337543550Prachayasittikul, S., A. Worachartcheewan, C. Nantasenamat, M. Chinworrungsee, N. Sornsongkhram, S. Ruchirawat and V. Prachayasittikul,201146738742Prachayasittikul, S., A. Worachartcheewan, R. Pingaew, T. Suksrichavalit, C. Isarankura-Na-Ayudhya, S. Ruchirawat and V. Prachayasittikul,20129282287Ressner, R.A., C.K. Murray, M.E. Griffith, M.S. Rasnake, D.R. Hospenthal and S.E. Wolf,2008206439444Shaw, A.Y., C.Y. Chang, M.Y. Hsu, P.J. Lu and C.N. Yang et al.,20104528602867Shen, A.Y., C.P. Chen and S. Roffler,199964813825Short, B.R., M.A. Vargas, J.C. Thomas, S. O`Hanlon and M.C. Enright,2006Staphylococcus aureus.]]>57104109Suksrichavalit, T., S. Prachayasittikul, T. Piacham, C. Isarankura-Na-Ayudhya, C. Nantasenamat and V. Prachayasittikul,20081330403056Suksrichavalit, T., S. Prachayasittikul, C. Nantasenamat, C. Isarankura-Na-Ayudhya and V. Prachayasittikul,20094432593265Tanzer, J.M., A.M. Slee, B. Kamay and E. Scheer,19781310441045