International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2013.125.133Syzygium cordatum Hoscht. ex C.Krauss (Mytraceae) in Rodents]]>DeliweM. AmabeokuG.J. 2201392Syzygium cordatum Hoscht. ex C.Krauss is widely used by traditional medicine practitioners to treat many ailments including diarrhoea and diabetes. Despite the folklore use, little evidence can be found in literature to corroborate the claims of therapeutic success of the plant species. The objective of the study was to investigate the antidiarrhoeal and antidiabetic activities of the leaf aqueous extract of the plant species in mice and rats, respectively. The antidiarrhoeal activity of the leaf aqueous extract of S. cordatum was investigated using castor oil-induced diarrhoeal test. The antidiabetic activity of the plant extract was studied using streptozotoxin-induced diabetes in rats. Acute toxicity study of plant extract was also carried out using a standard method. Leaf aqueous extract of S. cordatum significantly reduced the number of diarrhoeal episodes, decreased the stool mass and delayed the onset of castor oil-induced diarrhoea in mice. Loperamide was shown to protect the animals against castor oil-induced diarrhoea. Both the leaf aqueous extract of S. cordatum and chlorpropamide significantly lowered the blood glucose levels in both normal and streptozotoxin-induced diabetic rats. The LD50 value obtained for the plant extract was over 4000 mg kg-1 orally. The results obtained suggest that the leaf aqueous extract of S. cordatum has both antidiarrhoeal and antidiabetic activities. This justifies the folklore use of the plant species by traditional medicine practitioners to treat diarrhoea and diabetes. The relatively high LD50 value obtained for the leaf aqueous extract shows that the plant species is non toxic to mice.]]>Altman, D.F.,20012001pp: 1070-1071pp: 1070-1071Amabeoku, G.J. and C.G. Kinyua,2010Zanthoxylum capense (Thunb.) Harv. (Rutaceae) in mice.]]>6844853Bruneton, J.,19992nd Edn.,Pages: 1119Pages: 1119Camillen, M., R.C. Heading and W.G. Thompson,20021614071430Candy, H.A., E.J. McGarry, K.H. Pegel,1968Syzygium cordatum.]]>7889890Capasso, F., N. Mascolo, A.A. Izzo and T.S. Gaginella,199411311271130Chalannavir, R.K., H. Baijnath and B. Odhav,2011Syzygium cordatum (Myrtaceae).]]>1027412745Chisowa, E.H., G. Sakala, D.R. Hall and D.I. Farman,1998Syzygium cordatum Hochst. Ex Krauss.]]>10591592Di Carlo, G., N. Mascolo, A.A. Izzo and F. Capasso,199484245Dineshkumar, B., A. Mitra and M. Mahadevappa,2010murraya koenigii (rutaceae) leaves.]]>22230Farthing, M.J.,2000146569Fawzy, G.A., H.M. Abdallah, M.S.A. Marzouk, F.M. Soliman and A.A. Sleem,2008Cynanchum acutum L. (Asclepiadaceae) growing in Egypt.]]>63658662Frei, B., M. Baltisberger, O. Sticher and M. Heinrich,199862149165Harborne, J.B.,19842nd Edn.,Hule, A.K., A.S. Shah, M.N. Gambhire and A.R. Juvekar,2011Elaeocarpus ganitrus in experimental animals.]]>435659Hutchings, A.,1996pp: 1-11pp: 1-11Ikhiri, K., D. Boureima and D. Dan-Kouloudo,199230251262Joy, K.L. and R. Kuttan,1999Picrorrhiza kurroa extract.]]>67143148Lorke, D.,198354275287Mahomed, I.M. and J.A.O. Ojewole,2003Hypoxis hemerocallidea corm (African potato) aqueous extract in rats.]]>25617623Mascolo, N., A.A. Izzo, G. Autore, F. Barbato and F. Capasso,1994263291295Musabayane, C.T., N. Mahlalela, F.O. Shode and J.A. Ojewole,200597485490Nwafor, P.A., F.K. Okwuasaba and L.G. Binda,2000Asparagus pubescens root in rats.]]>72421427Punitha, I.S., A. Shirwaikar and A. Shirwaikar,200534117128Rang, H.P., M.M. Dale, J.M. Ritter and R.J. Flowers,20086th Edn.,pp: 402-408pp: 402-408Robert, A., J.E. Nezamis, C. Lancaster, A.J. Hanchar and M.S. Klepper,197611809828Sibandze, G.F., R.L. van Zyl and S.F. van Vuuren,2010Breonadia salicina, Syzygium cordatum and Ozoroa sphaerocarpa when used in combination in Swazi traditional medicine.]]>132506511Tunaru, S., T.F. Althoff, R.M. NĂ¼sing, M. Diener and S. Offermanns,20123 receptors.]]>10991799184Van Wyk, B.E., B. Van Oudtshoorn and N. Gericke,1997pp: 236-250pp: 236-250Waller, D.G., A.G. Renwick and K. Hillier,20052nd Edn.,pp: 417-418pp: 417-418Waller, D.G., A.G. Renwick and K. Hillier,20052nd Edn.,pp: 457-466pp: 457-466Watt, J.M., M.G. Breyer-Brandwijk,19622nd Edn.,pp: 97-98pp: 97-98Williamson, E.M., D.T. Okpako and F.J. Evans,1996Vol. 1,pp: 25-28pp: 25-28Williamson, E.M., D.T. Okpako and F.J. Evans,1996Vol. 1,pp: 155-167pp: 155-167Zavala, M.A., S. Perez, C. Perez, R. Vargas and R.M. Perez,1998Waltheria americana, Commelina coelestis and Alternanthera repens.]]>614147Kitano, Y., M. Makino, C. Usui, K. Takasuna and Y. Kasai et al.,199444199210