International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2012.628.637RahimiRoja AbdollahiMohammad 7201287The purpose of this study is to review all of these preparations
and evaluate their efficacy and safety. Electronic databases were searched to
obtain studies about the efficacy of locally used medications in the management
of post-hemorrhoidectomy complications. Data were collected for the years 1966
to 2012 (up to September). Finally 24 relevant studies were included. The topical
preparations used include botulinum toxin, Calcium Channel Blockers (CCBs),
Glyceryl Trinitrate (GTN), local anesthetics, metronidazole, opioids, sucralfate
and one herbal cream mainly consist of Aloe vera. Overall, topical preparations
showed encouraging results in reducing pain and analgesic use and improving
wound after hemorrhoidectomy. Because of better bioavailability and lower incidence
of adverse events compared with other dosage forms, it is suggested to use topical
preparations especially those with confirmed efficacy in the following order
o GTN, CCBs, metronidazole, local anesthetics, sucralfate and botulinum toxin.]]>Ala, S., M. Saeedi, F. Eshghi and P. Mirzabeygi,200851235238Amoli, H.A., A.Y. Notash, F.J. Shahandashti, A.Y. Kenari and H. Ashraf,201113328332Bragman S.G., C.L. Pankhurst and M.W. Casewell,199536703706Candiotti, K.,20123219S26SCellini, F. and V. Valentini,201226730735Cook, T.A., A.F. Brading and N.J. Mortensen,1999867075Coskun, A., S.A. Duzgun, A. Uzunkoy, M. Bozer, O. Aslan and B. Canbeyli,2001® band application for pain after hemorrhoidectomy.]]>44680685Davies, J., D. Duffy, N. Boyt, A. Aghahoseini, D. Alexander and S. Leveson,20034610971102Elton, C., P. Sen and A.C. Montgomery,20012353357Eshghi F., S.J. Hosseinimehr, N.Rahmani, M. Khademloo, M.S. Norozi and O. Hojati,201016647650Fioramonti, J. and L. Bueno,200251i91i95Gorfine, S.R., E. Onel, G. Patou and Z.V. Krivokapic,20115415521559Gupta, P.J., P.S. Heda, S. Kalaskar and V.P. Tamaskar,200851231234Guy, R.J. and F. Seow-Choen,200390147156Haas, E., E. Onel, H. Miller, M. Ragupathi and P.F. White,201278574581Ho, Y.H., F. Seow-Choen, J.Y. Low, M. Tan and A.P. Leong,199784377379Holzheimer, R.G.,200491836Hwang, D.Y., S. Yoon, H.S. Kim, J.K. Lee and K.Y. Kim,200346950954Jabbari, B. and D. Machado,20111215941606Jirasiritham, S., K. Tantivitayatan and S. Jirasiritham,200487660664Karanlik, H., R. Akturk, H. Camlica and O. Asoglu,200952280285Keshtkaran, A., S.V. Hosseini and L. Mohammadinia,201113267271Kua, K.B., H.M. Kocher, A. Kelkar and A.G. Patel,200171548550Lohsiriwat, V.,20121820092017Mirfazaelian, H., S. Nikfar, S. Derakhshani and M. Abdollahi,20122012Mounsey, A.L., J. Halladay and T.S. Sadiq,201184204210Nicholson, T.J. and D. Armstrong,200447711716Nikfar, S., R. Rahimi, A. Rezaie and M. Abdollahi,20095411571170Patti, R., A.P. Luigi, A. Matteo, S. Sergio, R. Pietro, F. Calogero and D.V. Gaetano,20064917411748Patti, R., P.L. Almasio, V.M.R. Muggeo, S. Buscemi, M. Arcara, S. Matranga and G. Di Vita,20054821732179Patti, R., M. Arcara, D. Padronaggio, S. Bonventre and M. Angileri et al.,2005577785Perrotti, P., P. Dominici, E. Grossi, R. Cerutti and C. Antropoli,2010531724Rahimi, M., A.R. Kazemeini, N. Pourtabatabaei and A.R. Honarmand,20122012Rahimi, R. and M. Abdollahi,201218589600Rahimi, R., S. Nikfar and M. Abdollahi,2007617580Rahimi, R., S. Nikfar and M. Abdollahi,2007131318Rahimi, R., S. Nikfar, A. Rezaie and M. Abdollahi,20075229202925Rahimi, R., S. Nikfar, A. Rezaie and M. Abdollahi,20062819831988Rahimi, R., S. Mozaffari and M. Abdollahi,200954471480Rahimi, R., M.R. Shams-Ardekani and M. Abdollahi,20101645044514Ratnasingham, K., M. Uzzaman, S.M. Andreani, D. Light and B. Patel,20108606611Rattan, S. and S. Chakder,1992262G107G112Rees, W.D.W.,19919158S63SRoe, A.M., D.C. Bartolo, K.D. Vellacott, J. Locke-Edmunds and N.J. Mortensen,198774948951Shiau, J.M., K.C. Hung, H.H. Chen, W.H. Chen, Y.H. Wu and C.C. Tseng,200723586590Shiau, J.M., H.P. Su, H.S. Chen, K.C. Hung, S.E. Lin and C.C. Tseng,2008333035Silverman, R., P.J. Bendick and H.J. Wasvary,20054819131916Tan, K.Y., K.K. Sng, K.H. Tay, J.H. Lai and K.W. Eu,20069314641468Tegon, G., L. Pulzato, L. Passarella, D. Guidolin, M. Zusso and P. Giusti,200913219224Van Cutsem, E., M. Dicato, K. Haustermans, N. Arber and J.F. Bosset et al.,20081918Wasvary, H.J., J. Hain, M. Mosed-Vogel, P. Bendick and S.N. Klein,20014410691073