International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2012.450.454Zanthoxylum nitidum Bark in Chemical and Stress Induced Gastric Mucosal Lesions in Male Albino Rats]]>BhattacharyaSanjib ZamanK. 5201285Zanthoxylum nitidum (Roxb.) DC (Rutaceae), called Tez-mui or Tejamool in Assamese, is a large prickly shrub occurring in North-Eastern India and its roots are used traditionally for several medicinal purposes. In the present study, the aqueous extract from the stem bark of Zanthoxylum nitidum (ZNA) was evaluated for its protective effects on gastric mucosal lesions in male Wistar albino rats against acetylsalicylic acid (ASA), ethanol and water immersion restraint stress induced gastric mucosal damage. In each model, ZNA was administered orally to rats at the doses of 100 and 200 mg kg-1 body weight, prior to chemical or stress challenge, followed by determination of ulcer index. Ranitidine hydrochloride at the dose of 35 mg kg-1, p.o. served as the reference drug. The test extract exhibited dose dependent and significant amelioration of gastric mucosal lesions in chemical (ASA and ethanol) as well as in stress-induced ulcers in male Wistar albino rats, thus confirming its antiulcer potential.]]>Anonymous,1976Vol. 9,Abd El-Kader, M.A., M.M. Ali, N.M. El-Sammad and M.A. El-Shaer,20116426438Alhaider, A.A., I.A. Al-Mofleh, J.S. Mossa, M.O. Al-Sohaibani, S. Rafatullah and S. Qureshi,2006Carum carvi on experimentally induced gastric mucosal damage in wistar albino rats.]]>2309315Alsaif, M.A.,20044102109Al-Attar, A.M.,2011Avicennia alba leaves extract on gastric mucosal damage induced by ethanol.]]>5477490Bacchi, E.M. and J.A.A. Sertie,1994Styrax camporum and Caesalpinia ferra in rats.]]>60118120Bhattacharya, S. and K. Zaman,2009Zanthoxylum nitidum grown in upper Assam region of India.]]>1148151Bhattacharya, S. and K. Zaman,2009Zanthoxylum nitidum bark.]]>1292298Bhattacharya, S. and M.K. Zaman,2009Zanthoxylum nitidum root.]]>11521Bhattacharya, S., M.K. Zaman and P.K. Haldar,2009Zanthoxylum nitidum.]]>23034Bhattacharya, S., P.K. Haldar and M.K. Zaman,2010Zanthoxylum nitidum stem bark extracts in experimental animal models.]]>718Bhattacharya, S., P.K. Haldar and M.K. Zaman,2010in vitro antioxidant property of Zanthoxylum nitidum root.]]>4774783Bhattacharya, S. and M.K. Zaman,2011In vitro antioxidative effects of stem bark from Zanthoxylum nitidum (Roxb.) DC (Rutaceae).]]>712161223Bhattacharya, S., P.K. Haldar and M.K. Zaman,2011Zanthoxylum nitidum bark.]]>11271277Brodie, D.A., R.W. Marshall and M. Morneo,1962202812814Fang, S.D., L.K. Wang and S.M. Hecht,1993Zanthoxylum nitidum.]]>5850255027Gill, N.S., J. Bajwa, P. Sharma, K. Dhiman and S. Sood et al.,2011Cucumis melo seeds.]]>68289Gill, N.S., A. Sharma, R. Arora and M. Bali,2011Cassia tora seeds for their antioxidant and antiulcer activity.]]>1196101Glavin, G.B. and S. Szabo,19926825831Harborne, J.B.,1998Pages: 302Pages: 302Hayase, M. and K. Takeuchi,198631166171Hollander, D., A. Taranawski, W.J. Krause and H. Gergely,198588366374Hu, K., A. Dong, H. Liu, H. Feng Q. Sun and X. Yao,1999Pyricularia oryzae.]]>37225230Hu, J., W.D. Zhang, R.H. Liu, C. Zhang, Y.H., X.K. Xu, M.J. Liang and H.L. Li,2006Zanthoxylum nitidum.]]>3116891691Hu, J., W.D. Zhang, Y.H. Shen, C. Zhang, L. Xu and R.H. Liu,2007Zanthoxylum nitidum (Roxb.) DC.]]>35114117Kamsiah, J., W. Muhaizan, M.T. Gapor and O. Roslin,200519397Kanjilal, U.N.,1997Vol. I,Kirtikar, K.R. and B.D. Basu,1933Vol. I,Kisaoglu, A., B. Ozogul, N. Cetyn, B. Suleyman, S. Atamanalp, F. Akcay and H. Suleyman,20117682689Kunle, O.O., A. Shittu and R.N. Nasipuri,1999Ficus sur.]]>70542547Liu, X.M., M.N.M. Zakaria and M.W. Islam,2001Calligonum comosum in rats.]]>72487491Loguercio, C., D. Taranto, F. Beneduce, V.V. Balance and A. Vincentis,199334161165Parmar, N.S. and J.K. Desai,199325120135Paul, R.K., A. Jabbar and M.A. Rashid,2000Mikania cordata.]]>71701703Al-Rejaie, S.S.,20095146154Shyur, L.F., J.H. Tsung, J.H. Chen, C.Y. Chiu and C.P. Lo,20053195202Suffnes, M. and G.A. Cordell,19851985pp: 178-187pp: 178-187Tripathi, K.D.,2008Pages: 940Pages: 940Vane, J.R., 1971231232235