International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2012.382.388Pimpinella tirupatiensis on Altered Urea Cycle and Liver Function Markers in Diabetic Rats]]>NarasimhuluG. LavanyaT. ReddyS. RajeswaraMallikarjunaK. RaoP. VisweswaraAdamAishah ReddyK. Sathyavelu5201285Recent studies are emphasizing on cure and or prevent the diabetes-associated complications by using herbal medicines, since complications are increasing around the world. The present study was aimed to investigate the pharmacological efficacies of Pimpinella tirupatiensis (Pt) extracts against diabetes-associated altered urea cycle and liver function markers. In this study, diabetes was induced by streptozotocin (STZ) injection (40 mg kg-1 b.wt.) in rats, and treated with P. tirupatiensis extracts for 30 days (750 mg kg-1 b.wt. orally). The significant (p<0.01) decrease in body weights, elevated serum glucose, urea, uric acid and creatinine levels along with elevated Aspartate amino transferase (AST) and Alanine amino transferase (ALT) activities were observed in diabetic rats. Interestingly, diabetic rats treated with P. tirupatiensis aqueous extracts showed significantly (p<0.01) lowered serum glucose levels and regained body weights compared to untreated diabetic rats. Elevated urea and uric acid contents were also significantly (p<0.01) controlled by P. tirupatiensis, which were similar to the standard anti-diabetic drug glibenclamide treatment. Furthermore, increased both AST and ALT activities were attenuated by P. tirupatiensis, which indicates diabetes-induced adverse effects on liver function markers were alleviated. These results clearly demonstrating that increased hostile milieu in urea cycle and liver function markers under diabetic condition could be reversed by P. tirupatiensis treatment. This study suggests that P. tirupatiensis aqueous extracts may be used as anti-diabetic remedy, however further confirmatory studies are necessary.]]>Almdal, T.P., K.F. Petersen, B.A. Hansen and H. Vilstrup,198629812816Anwar, M.M. and A.R.M.A. Meki,2003135539547Eidi, A., M. Eidi, P. Shahmohammadi, V. Mozaffarian, A. Rustaiyan and A. Mazooji,2011Salvia verticillata L. aerial parts in normal and streptozotocin-induced diabetic rats.]]>76673Baynes, J.W.,199140405412Becker, B.F.,199314615631Sharma, B., G. Viswanath, R. Salunke and P. Roy2008Eugenia jambolana (L.) on carbohydrate and lipid metabolism in diabetic mice.]]>110697705O'Brien, R.M. and D.K. Granner,1991278609619Harris, E.H.,200523115119Facchini, F., Y.D. Chen, C.B. Hollenbeck and G.M. Reaven,199126630083011Fossati, P., L. Prgncipe and G. Berti,198026227231Green, M. and L.L. Miller,196023532023208Hu, X., J. Sato, Y. Oshida, M. Xu, G. Bajotto and Y. Sato,200359103111Madhava Chetty, K. and K.N. Rao,199031215Madinov, I.V., M.I. Balabolkin and D.S. Markov and T.N. Markova,2000725558Modan, M., H. Halkin, A. Karasik and A. Lusky,198730713718Moss, D.W. and A.R. Handerson,19991999pp: 617-721pp: 617-721Muhlhauser, I., P.T. Sawicki, M. Blank, H. Overmann, R. Bender and M. Berger,2000248333341Haque, N., U. Salma, T.R. Nurunnabi, M.J. Uddin, M.F.K. Jahangir, S.M.Z. Islam and M. Kamruzzaman,2011141324Pari, L.J. and J. Umamaheswari,2000Musa sapientum flowers: Effect on lipid peroxidation in alloxan diabetic rats.]]>14136138Rao, P.V., K. Madhavi and M.D. Naidu,2011Rhinacanthus nasutus in streptozotocin induced diabetic rats.]]>6589595Lawson-Evi, P., K. Eklu-Gadegbeku, A. Agbonon, K. Aklikokou, E. Creppy and M. Gbeassor,2011Phyllanthus amarus schum and thonn (Euphorbiaceae) on alloxan induced diabetes in male wistar rats.]]>1129682973Rakieten, N., M.L. Rakieten and M.V. Nadkarni,1963299198Jasmine, R. and P. Daisy,2007Eugenia jambolana in streptozotocin-diabetic rats.]]>1117121Rates, S.M.K.,200139603613Thomas, L.,19981st Edn.,pp: 208-214pp: 208-214Thomas, L.,19981st Edn.,pp: 366-374pp: 366-374Travlos, G.S., R.W. Morris, M.R. Elwell, A. Duke, S. Resenblum and M.B. Thompson,19961071729Urger, R.H. and D.W. Foster,19981998pp: 973-1060pp: 973-1060Barham, D. and P. Trinder,197297142145