International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2012.277.282Guazuma ulmifolia
Lamk. Leaves and Curcuma xanthorrhiza Roxb. Rhizomes Extract in Wistar
Rats]]>SukandarE.Y. Nurdewi Elfahmi 4201284Guazuma ulmifolia Lamk. (mutamba) and Curcuma xanthorrhiza Roxb. (java turmeric) has been used traditionally as slimming agent and for treating various diseases including hypercholesterolemia. In this study, the effect of aqueous extract of mutamba leaves in combination with ethanol extract of java turmeric has been determined on lipid blood level of Wistar rats compared to each extract alone in hyperlipidemic induced rats. Thirty male rats weighing 180-200 g were divided into six groups receiving mutamba extract, java turmeric extract, simvastatin as a reference of antihyperlipidemic drug, combination of mutamba and java turmeric at two different doses and one control group. The extract was given daily for 14 days at the same time as the administration of propylthiouracil and food high in cholesterol content to induce hyperlipidemia. The serum levels of total cholesterol, triglyceride, HDL and LDL were measured after 3, 7 and 14 days of treatment. The result were analyzed statistically using ANOVA. The results indicated that combination of aqueous extract of mutamba leaves at a dose of 25 mg kg-1 b.wt. and ethanol extract of Java turmeric rhizome at a dose of 12.5 mg kg-1 b.wt. decreased total cholesterol and LDL level significantly compared to control group (p = 0.004) after 7 days of treatments. Aqueous extract of mutamba leaves at a dose of 50 mg kg-1 b.wt. did not show any significant effect while ethanol extract of java turmeric rhizome at a dose of 25 mg kg-1 b.wt. decreased only LDL level significantly.]]>Abdel-Latif, H. and I.A. Sadek,1999211931196Alonso-Castro, A.J. and L.A. Salazar-Oliva,2008Guazuma ulmifolia Lam are mediated by the stimulation of glucose uptake in normal and diabetic adipocytes without inducing adipogenesis.]]>118252256Dipiro, J.T., R.L. Talbert, G.C. Yee, G.R. Matzke, B.G. Wells and L.M. Posey,20087th Edn.,pp: 144pp: 144EL-Sherbiny, M., M.M. Abdel-Aziz, K.A. Elbakry, E.A. Toson and A.T. Abbas,20061627633Lopes, G.C., R. Longhini, P.V.P. dos Santos, A.A.S. Araujo, M.L. Bruschi and J.C.P. de Mello,2012Guazuma ulmifolia Lam (Sterculiaceae).]]>2012Hanapi, N.A., J. Azizi, S. Ismail and S.M. Mansor,2010in vitro.]]>6494499Hasimun, P., E.Y. Sukandar, I.K. Adnyana and D.H. Tjahjono,20117268272Hussein, H.K. and O.A. Abu-Zinadah,20106266276Itokawa, H., Q. Shi, T. Akiyama, S.L. Morris-Natschke and K.H. Lee,20082008Kasahara, S. and S. Hemmi,19952nd Edn. Vol. 77,Pages: 272Pages: 272Kuroda, M., Y. Mimaki, T. Nishiyama, T. Mae and H. Kishida et al.,2005Curcuma longa L. Rhizomes) on genetically diabetic KK-Ay mice.]]>28937939Pizana, C.G., L.L.B. Necha and M.Y.R. Gomez,2010Fusarium oxysporum f.sp. gadioli (Massey) snyder and hansen.]]>9103111Magos, G.A., J.C. Mateos, E. Paez, G. Fernandez, C. Lobato, C. Marquez and R.G. Enriquez,2008Guazuma ulmifolia bark in normotensive and hypertensive rats.]]>1175868Maheshwari, R.K., A.K. Singh, J. Gaddipati and R.C. Srimal,20067820812087Sivabalan, S. and C.V. Anuradha,2010in vitro assays.]]>6664669Sovia, E., E.Y. Sukandar, J.I. Sigit and L.D.N. Sasongko,20117410414Sukandar, E.Y., J.I. Sigit and R. Deviana,2010Allium sativum L.) and turmeric (Curcuma longa L.) extract and its combination to lipoprotein profile and blood glucose level in rats.]]>118Sukandar, E.Y., H. Permana, I.K. Adnyana, J.I. Sigit, R.A. Ilyas, P. Hasimun and D. Mardiyah,2010Curcuma longa L.) and garlic (Allium sativum L.) extracts as antihyperglycemic and antihyperlipidemic agent in type-2 diabetes-dyslipidemia patients.]]>6456463Sukandar, E.Y.,2009Guazuma ulmifolia Lamk) leaves on blood lipid level of male rats.]]>8102112Sukisamrarn, A., S. Eiamong, P. Piyachaturawat and J. Charoenpiboonsin,1994Curcuma xanthorrhiza.]]>3615051508Wientarsih, I., S. Chakeredza and U. ter Meulen,2002Curcuma xanthorrhiza Roxb) on lipid metabolism in rabbits.]]>8218751880Yasni, S., K. Imainizumi, M. Nakamura, J. Aimoto and M. Sugano,1993Curcuma xanthorrhiza Roxb. and curcuminoids on the level of serum and liver lipids, serum apolipoprotein A-I and lipogenic enzymes in rats.]]>31213218Yasni, S., K. Imaizumi, K. Sin, M. Sugano, G. Nonaka and Sidik,1994Curcuma xanthorrhiza Roxb. Showing triglyceride-lowering action in rats.]]>32273278