International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2012.198.203Cinnamomum iners Bark]]>AnnegowdaH.V. GooiT.S. AwangS.H.H. AliasN.A. MordiM.N. RamanathanS. MansorS.M. 3201283The multiple traditional uses with fewer scientific investigations about C. iners bark made imperative to further exploit this plant for the evaluation of its therapeutic value. Analgesic and antioxidant activities of ethanolic, aqueous and alkaloid extracts prepared from C. iners bark was studied using both in vivo and spectrometric experimental models. Results of hot plate and tail flick studies show that all the screened extracts are devoid of central analgesic activity. However, promising findings regarding the peripheral analgesic and anti-inflammatory activity was revealed from the formalin induced pain method with alkaloid extract possessing significant activity followed by ethanolic and aqueous extract. Moreover, the results of total phenolic content and antioxidant activity was also confirmed the presence of higher amount polyphenolic content in ethanolic extract with significant antioxidant activity. The observed peripheral analgesic activity by ethanolic and aqueous extract might be due to the presence of higher amount polyphenolic present in them. Results of this study also supported the traditional use of this plant in the treatment of pain. Hence, it was concluded from the study that C. iners bark extract can be utilized as new source of peripheral analgesic in the treatment of pain.]]>Abdul, A.B., S.I. Abdel-Wahab, A.S. Al-Zubairi, M.M. El-Hassan and S.M. Murali,2008Zingiber zerumbut.]]>4301304Annegowda, H.V., M.N. Mordi, S. Ramanathan and S.M. Mansor,2010Terminalia catappa L. Leaves.]]>6910915Annegowda, H.V., C.W. Nee, M.N. Mordi, S. Ramanathan and S.M. Mansor,2010Terminalia catappa L. leaf.]]>9479485Annegowda, H.V., M.N. Mordi, S. Ramanathan, M.R. Hamdan and S.M Mansor,2011Bauhinia purpurea: HPTLC determination of antioxidants.]]>2011Baruah, A., S. Nath and A. Hazarika,2001Cinnomomum iners reinw.]]>45261263Butkhup, L. and S. Samappito,2011In vitro free radical scavenging and antimicrobial activity of some selected Thai medicinal plants.]]>5254265Cuzzocrea, S., B. Zingarelli, P. Hake, A.L. Salzman and C. Szabo,199824450459D'Amour, F.E. and D.L. Smith,1941727479De Melo, G.O., D.C. Malvar, F.A. Vanderlinde, F.F. Rocha and P.A. Pires et al.,2009Sedum dendroideum.]]>124228232Eidi, A., M. Eidi, V. Mozaffarian, A. Rustaiyan, A. Mazooji, Z. Khaboori and F. Nabiuni,2011Salvia syriaca L. in mice.]]>7394399Hunskaar, S. and K. Hole,198730103114Jantan, I., M.A. Rasadah and S.H. Goh,1994Cinnamomum species from Peninsular Malaysia.]]>6286292Kim, H.P., K.H. Son, H.W. Chang and S.S. Kang,200496229245Krishnan, N., S. Ramanathan, S. Sasidharan, V. Murugaiyah and S.M. Mansor,2010Cassia spectabilis leaf extracts.]]>6510514McCurdy, C.R. and S.S. Scully,200578476484Malmberg, A.B. and T.L. Yaksh,199511410691075Mohan, S., A.B. Abdul, S.I. Abdel-Wahab, A.S. Al-Zubairi, M.M. Elhassan and M. Yousif,2008Typhonium flagelliforme (Lodd.) blume tuber.]]>4402407Makambila-Koubemba, M.C., B. Mbatchi, D. Ardid, A. Gelot and C. Henrion et al.,20117608615Mustaffa, F., J. Indurkar, S. Ismail, M.N. Mordi, S. Ramanathan and S.M. Mansor,2010Cinnomomum iners leaves methanolic extract.]]>27681Mustaffa, F., J. Indurkar, S. Ismail, M.N. Mordi, S. Ramanathan and S.M. Mansor,2010Cinnomomum iners standardized leaves methanolic extract.]]>6888895Nguyen, M.T.T., S. Awale, Y. Tezuka, Q.L. Tran, H. Watanabe and S. Kadota,20042714141421Pang, K.L., W.L. Thong and S.E. How,20091310313Phutdhawong, W., R. Kawaree, S. Sanjaiya, W. Sengpracha and D. Buddhasukh,2007Cinnamomum iners Reinw. ex Bl.: comparison with conventional hydrodistillation.]]>12868877Prieto, P., M. Pineda and M. Aguilar,1999269337341Santos, A.R. and J.B. Calixto,199731381389Santos, A.R., E.M. Vedana and G.A. De Freitas,199847302307Singleton, V.L. and J.A. Rossi,196516144158Tjolsen, A., O. Berge, S. Hunskaar, J. Rosland and K. Hole,199251517Toker, G., E. Kupeli, M. Memisoglu and E. Yesilada,2004Tilia argentea (silver linden).]]>95393397Vogel, H.G.,20022nd Edn.,pp: 694-696pp: 694-696Abdel-Wahab, S.I., A.B. Abdul, S.M. Mohan, A.S. Al-Zubairi, M.M. Elhassan and M.Y. Ibrahim,2009Pereskia bleo extracts.]]>57175Wiart, C., S. Mogana, S. Khalifah, M. Mahan and S. Ismail et al.,2004756873Woolfe, G. and A.D. MacDonald,194480300307Kumar, Y.R. and G.P. Rajani,2011Bauhinia variegata Linn.]]>7616622Blois, M.S.,195818111991200