International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.868.873AlqasoumiSaleh YusufogluHasan FarrajAbdullah AlamAftab 8201178This study was designed to investigate the protective effect of 6-shogaol and 6-gingerol against hepatotoxicity induced by diclofenac sodium (DFS). Compounds 6-shogaol and 6-gingerol were isolated from 5% gingerol oleoresin and their potential hepatoprotective activity was evaluated. Hepatotoxicity was induced in rats by an intra-peritoneal (i.p.) injection of DFS (150 mg kg-1). Rats were i.p. injected with 6-shogaol and 6-gingerol (10 mg kg-1) for 6 days before induction of hepatotoxicity. Blood and liver sample were taken from each rat at 24 h post intoxication. Serum activity of liver marker enzymes such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assayed. Levels of alkaline phosphates enzymes (ALP) and total bilirubin in serum and malondialdehyde (MDA) in the liver homogenate were also estimated. Moreover, liver injury was assayed histologically. Results of present study revealed that i.p. injection of DFS to rats induced hepatic damaged that was manifested by significant (p<0.001) increase in the AST, ALT, ALP, total bilirubin in serum and MDA in liver homogenate. Histological data presented marked damaged in section of liver from DFS treated rats. I.p. injection of 6-shogaol to rats for 6 days before DFS-intoxication reversed these altered parameters near to normal control values. On the other hand, 6-gingerol had comparatively low hepatoprotective efficacy.]]>Agarwal, R., C. Agarwal, H. Ichikawa, R.P. Singh and B.B. Aggarwal,20062644574498Ajith, T.A., U. Hema and M.S. Ahwathy,2007Zingiber officinale roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status.]]>4522672272Alqasoumi, S.I., M.S. Al-Dosari, A.M. AlSheikh and M.S. Abdel-Kader,2009Fumaria parviflora and Momordica balsamina from Saudi folk medicine against experimentally induced liver injury in rats.]]>3915Amin, A. and A.A. Hamza,2005208367375Aydin, G., A. Gokcimen, E. Cicek and O. Gokalp,20032711311140Bort, R., X. Ponsoda, R. Jover, M.J. Gomez-Lechon and J.V. Castell,19992886572Cantoni, L., R. Valaperta, X. Ponsoda, J.V. Castell and D. Barelli et al.,200538776783Cavin, C., K. Mace, E.A. Offord and B. Schilter,200139549556Dugasani, S., M.R. Pichika, V.D. Nadarajah, M.K. Balijepalli, S. Tandra and J.N. Korlakunta,2010127515520Ezeuko, V.C., C.R. Nwokocha, P.E. Mounmbegna and C.C. Nriagu,2007Ginger officinale on liver function of Murcuric chloride-induced hepatotoxicity in adult wister rats.]]>34045Ficker, C., M.L. Smith, K. Akpagana, M. Gbeassor and J. Zhang et al.,200317897902Flynn, DL., M.F. Rafferty and A.M. Boctor,198624195198Galati, G., S. Tafazoli, O. Sabzevari, T.M. Chan and P.J. O'Brien,20021422541Gill, M., M.C. Ramirez, M.C. Terencio and J.V. Castell,19951272140146Graupera, M., J.C. Garcia-Pagan, E. Titos, J. Claria, A. Massaguer, J. Bosch and J. Rodes,2002122387393Hamza, A.A.,2007Curcuma longa, Glycyrrhiza glabra and Moringa oleifera ameliorate diclofenac-induced hepatoxicity in rats.]]>28088Hikino, H., Y. Kiso, N. Kato, Y. Hamada and T. Shioiri et al.,1985143139Ibrahim, M.Y., A.B. Abdul, S.I. Abdel Wahab, M.M. Elhassan, A.S. Alzubairi and M.M. Syam,20094777784Kim, J.K., Y. Kim, K.M. Na, Y.J. Surh and T.Y. Kim,2007in vitro and in vivo.]]>41603614Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439Kaplowitz, N.,20054489499Kim, S.O., J.K. Kundu, Y.K. Shin, J.H. Park, M.H. Cho, T.Y. Kim and Y.J. Surh,20054125582567Laine, L.,2001120594606Lewis, J.H.,19892543561Mallikarjuna, K., C.P. Sahitya, R.K. Sathyavelu and W. Rajendra,200879174178Manov, I., H. Motanis, I. Frumin and T.C. Iancu,200627259272Mansour, H.H., H.F. Hafez and N.M. Fahmy,200639656661Mascolo, N., R. Jain, S.C. Jain and F. Capasso,1989Zingiber officinale).]]>27129140Masubuchi, Y., S. Nakayama and T. Horie,200235544551Najafzadeh, H., M.R. Jalali, H. Morovvati and F. Taravati,201062226Paul, A.D. and C.K. Chauhan,200560889892Pithayanukul, P., S. Nithitanakool and P. Bavovada,20091449875000Sadasivan, S., P.G. Latha, J.M. Sasikumar, S. Rajashekaran, S. Shyamal and V.J. Shine,2006Hedyotis corymbosa (L.) Lam.]]>106245249Sallie, R., J.M. Tredger and R. Williams,199112251259Schapira, D., L. Bassan, A.M. Nahir and Y. Scharf,1986626365Schwertner, H.A. and D.C. Rios,20078564147Shati, A.A. and F.G. Elsaid,2009Thymus vulgaris) and ginger (Zingiber officinale Roscoe) on alcohol abuse.]]>4719451949Tang, W., R.A. Stearns, S.M. Bandiera, Y. Zhang and C. Raab et al.,199927365372Thompson, R.P.H.,196922439441Titos, E., J. Claria, A. Planaguma, M. Lopez-Parra and A. Gonzalez-Periz et al.,200578871878Verma, R.J. and V. Asnani,200764271280