International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.801.812Zingiber officinale) in Wistar Rats]]>MalikZ.A. SharmaaP.L. 8201178The aim of the present study was to investigate the anti-obesity effects of the ginger in a rat model of high-fat diet induced obesity. In the preventive study, male Wistar rats were fed high-fat diet along with different doses of ginger (0.25-1 g/day p.o o.d). for 8 weeks. In the ameliorative study obese rats were selected after 8 weeks feeding of high-fat diet and then treated with different doses of ginger (0.25-1 g/day p.o o.d). for 8 weeks along with high-fat diet or normal chow diet. The effect of these treatments on changes in feed intake, body weight, Lees index, adipose tissue weight, core body temperature (an index of thermogenesis) and serum biochemicals were analyzed. In preventive study ginger treatment not only decreased body weight gain, Lees index, adipose tissue weight but also enhanced thermogenesis and improved glucose and lipid homeostasis. These beneficial effects were attenuated by propranolol indicating the role of beta-adrenoceptors. Ginger treatment also ameliorated established obesity and associated biochemical consequences and more so when high-fat diet was replaced with normal diet signifying the importance of dietary modification in successful obesity therapy. Ginger treatment was found devoid of any toxicity as assessed by liver enzyme levels and weights of vital organs. The results suggest that chronic administration of ginger can inhibit the development of obesity and associated metabolic consequences in high-fat diet induced obesity without significant adverse effect.]]>Afoakwah, A.N. and W.B. Owusu,20113113Afridi, A.K., M. Safdar, M.M.A.K. Khattak and A. Khan,20032350360Afzal, M., D. Al-Hadidi, M. Menon, J. Pesek and M.S.I. Dhami,200118159190Al-Amin, Z.M., M. Thomson, K.K. Al-Qattan, R. Peltonen-Shalaby and M. Ali,2006Zingiber officinale) in streptozotocin-induced diabetic rats.]]>96660666Al-Attar, A.M. and T.A. Zari,200733440Ali, B.H., G. Blunden, M.O. Tanira and A. Nemmar,2008Zingiber officinale Roscoe): A review of recent research.]]>46409420Bergman, R.N., S.P. Kim, I.R. Hsu, K.J. Calalano and J.D. Chiu et al.,2007120S3S8Bernardis, L.L. and B.D. Patterson,196840527528Bhandari, U., J.N. Sharma and R. Zafar,1998Zingiber officinale) extract in cholesterol fed rabbits.]]>61167171Brown, M., C. Bing, P. King, L. Pickavance, D. Heal and J. Wilding,200113218981904Connoley, I.P., Y.L. Liu, I. Frost, I.P. Reckless, D.J. Heal and M.J. Stock,199912614871495Despres, J.P., I. Lemieux and N. Almeras,200630S44S52Dreon, D.M., B. Frey-Hewitt, N. Ellsworth, P.T. Williams, R.B. Terry and P.D. Wood,1988479951000Ebrahimi-Mameghani, M., M. Saghafi-Asl, S. Arefhosseini and M. Khoshbaten,200811443447Eldershaw, T.P., E.Q. Colquhoun, K.A. Dora, Z.C. Peng and M.G. Clark,1992Zingiber officinale) are thermogenic in the perfused rat hindlimb.]]>16755763Franssila-Kallunki, A., A. Rissanen, A. Ekstrand, A. Ollus and L. Groop,199256247S248SFuhrman, B., M. Rosenblat, T. Hayek, R. Coleman and M. Aviram,200013011241131Fujisawa, F., T. Nadamoto and T. Fushiki,20055839Goyal, R.K. and S.V. Kadnur,2006Zingiber officinale on gold thioglucose induced obesity.]]>77160163Greenway, F.L., E. Dunayevich, G. Tollefson, J. Erickson and M. Guttadauria et al.,20099448984906Hameed, A., S.A. Malik, F. Rabbi, A. Sharif and N. Ahmad et al.,20022710714Han, L.K., X.J. Gong, S. Kawano, M. Saito, Y. Kimura and H. Okuda,2005Zingiber officinale Roscoe.]]>125213217Harrold, J.A., P.S. Widdowson, J.C. Clapham and G. Williams,2000279E340E347Ioannides-Demos, L.L., J. Proietto, A.M. Tonkin and J.J. McNeil,200629277302Iwasaki, Y., A. Morita, I. Iwasawa, K. Kobata and Y. Sekiwa et al.,200696169178Klein, B.P. and A.K. Perry,198247941945Lewington, S., G. Whitlock, R. Clarke, P. Sherliker and J. Emberson et al.,200737018291839Litchfield, Jr. J.T. and F. Wilcoxon,19499699113Malik, Z.A., A. Goyal and P.L. Sharma,201134352Malik, Z.A., M. Singh and P.L. Sharma,2011Momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice.]]>133729734Mantha, L., E. Palacios and Y. Deshaies,1999277R455R464Nammi, S., S. Sreemantula and B.D. Roufogalis,2009Zingiber officinale rhizome on the development of metabolic syndrome in high-fat diet-fed rats.]]>104366373Ness, G.C., Z. Zhao and D. Lopez,1996325242248Nguyen, D.M. and H.B. El-Serag,20103917Nicoll, R. and M.Y. Henein,2009Zingiber officinale Roscoe): A hot remedy for cardiovascular disease?]]>131408409Oakes, N.D., G.J. Cooney, S. Camilleri, D.J. Chisholm and E.W. Kraegen,19974617681774Pulbutr, P., K. Thunchomnang, K. Lawa, A. Mangkhalathon and P. Saenubol,20117629634Ranganna, S.,19862nd Edn.,Pages: 1112Pages: 1112Rolls, B.J. and V.A. Hammer,1995621086S1095SRouhi, H., G. Forouzan and N. Hamid,20065373376Sharpe, P.A., M.L., Granner, J.M. Conway, B.E. Ainsworth and M. Dobre,200610620452051Singleton, V.L. and J.A. Rossi,196516144158Sivakumar, V. and S. Sivakumar,2004Rattus norvegicus.]]>18976981Srinivasan, K. and K. Sambaiah,199161364369St-Pierre, J., I. Lemieux, P. Perron, D. Brisson and M. Santure et al.,200799369373Tannenbaum, B.M., D.N. Brindley, G.S. Tannenbaum, M.F. Dallman, M.D. McArthur and M.J. Meaney,1997273E1168E1177Tapsell, L.C., I. Hemphill, L. Cobiac, C.S. Patch and D.R. Sullivan et al.,2006185S4S24Trease, G.E. and W.C. Evans,198913th Edn.,Pages: 832Pages: 832Wadden, T.A., M.L. Butryn and K.J. Byrne,200412151S162SWebber, J. and I.A. Macdonald,200059397404Weyer, C., J.F. Gautier and E. Danforth Jr.,1999251121Weyer, C., R.L. Walford, I.T. Harper, M. Milner, T. MacCallum, P.A. Tataranni and E. Ravussin,200072946953Wilding, J.P., S.G. Gilbey, M. Mannan, N. Aslam, M.A. Ghatei and S.R. Bloom,1992132299304York, D.A., S. Thomas, F.L. Greenway, Z, Liu and J.C. Rood,200721010Zou, Y., Y. Lu and D. Wei,2004Hypericum perforatum L. in vitro.]]>5250325039Awang, D.V.C.,1992125309311