International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.532.535Momordica charantia Fruit Extract on Normal and Alloxan-Diabetic Rats]]>KolawoleO. T.AbionaF. E.KolawoleS. vAyankunleA. A.OlaniranO. I.4201174The antidiabetic activity of Momordica charantia (bitter gourd) fruit Methanol Extract (MCE) was investigated in normal and diabetic rats. Animals were treated intraperitoneally with a single dose of 120 mg kg-1 alloxan to induce diabetes. This resulted in significant increase in plasma glucose level. The diabetic and normal rats were both randomly divided into 5 groups. Group A (control) received distilled water ad libitum. Groups B, C and D were treated orally with daily doses of 200, 400 and 600 mg kg-1 of MCE respectively for 28 days. Group E received 10 mg kg-1 chlorpropamide for the same period. Administration of MCE produced a dose-dependent decrease in blood glucose level in both normal and diabetic animals. The decrease was significant (p<0.05) with 400 and 600 mg kg-1 of the extract. This is comparable to the effect of clorpropamide. Contrary to some negative findings, the results of this study show that chronic oral administration of extract of Momordica charantia fruits at an appropriate dosage may be a good alternative antidiabetic agent.]]>Adewole, S.O. and J.A.O. Ojewole,2008Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats.]]>63041Assubaie, N.F. and M.M. El-Garawany,2004Momordica charantia cultivated in Hofuf, Saudi Arabia.]]>4628630Ataman, J.E., D.B. Grillo, E.K.I. Omongbai, M. Idu, F. Amaechina, V. Okonji and B.A. Ayinde,2006Momordica charantia L. leaves on alloxan treated wistar rats.]]>6828832Bavarva, J.H. and A.V.R.L. Narasimhacharya,2007Phyllanthus niruri. in normal and diabetic rats.]]>45569574Boyle, J.P., A.A. Honrycult, K.M. Narayan, T.J. Hoerger, L.S. Geiss, H. Chen and T.J. Thompson, 20012419361940Ceriello, A.,20032615891596Abd El-Ghaffar, N. and N.H. El-Said,,20066626630Grover, J.K., S. Yadav and V. Vats,20028181100Keen, R.W., A.C. Deacon, H.T. Delves, J.A. Moreton and P.G. Frost,199470113114Kumar, R., S. Balaji, T.S. Uma and P.K. Sehgal,2009Momordica charantia potentiate glucose uptake and up-regulate Glut-4, PPARγ and P13K.]]>126533537Manzella, D., M. Barbieri, E. Ragno and G. Paolisso,20017310521057Miura, T., C. Itoh, N. Iwamoto, M. Kato, M. Kawai, S.R. Park and I. Suzuki,2001Momordica charantia in type 2 diabetic mice.]]>47340344NIH,19851985Pavana, P., S. Sethupathy and S. Manoharan,2008Tephrosia purpurea ethanolic seed extract on glycoprotein components in streptozotocin induced diabetic rats.]]>4114119Raman, A. and C. Lau,1996Momordica charantia L. (Cucurbitaceae).]]>2349362Rao, B.K., M.M. Kesavulu and C. Apparao,2001Momordica cymbalaria in alloxan diabetic rats.]]>786771Sathishsekar, D. and S. Rajasekaran,2007Momordica charantia seeds extract on membrane bound ATPases and lysosomal hydrolases in rats with streptozotocin diabetes.]]>2293301Schnell, O. and E. Standl,2006121619Scoppola, A., F.R. Montecchi, G. Mezinger and A. Lala,2001156357361Shetty, A.K., G.S. Kumar, K. Sambaiah and P.V. Salimath,2005Momordica charantia) in glycaemic status in streptozotocin induced diabetic rats.]]>60109112Virella-Lopes, M.F. and G. Virella,20038750768Murthy, B.K., S. Nammi, M.K. Kota, R.V.K. Rao, N.K. Rao and A. Annapurna,2004Datura metel (Linn.) seeds in normal and alloxan-induced diabetic rats.]]>919598Paul, A. and S.S. Raychaudhuri,2010Momordica charantia varieties-a review.]]>64351Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439