International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.504.509Solanum nigrum and Cichorium intybus]]>SubashK. R.RameshK. S.CharianBinoy VargheeseBrittoFrancis RaoJagan N.VijaykumarS. 4201174The study was conducted to evaluate the hepatoprotective activity of Solanum nigrum and Cichorium intybus. Hepatotoxicity was induced in albino rats with 1:1(v/v) mixture of CCL4 in olive oil, administered at the dose of 1.5 mg kg-1 i.p on 7th day. The extract of Solanum nigrum and Cichorium intybus were administered to the experimental rats. The hepatoprotective effect of these extracts was evaluated by the assay of serum protein, Serum bilirubin and serum enzymes like Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT) and Markers for oxidative stress like Glutathione (GSH), Superoxide Dismutase (SOD), Lipid Peroxidase (LPO) and histopathological studies of liver. In the groups where hepatic injury induced by CCL4 and extract were given simultaneously, the toxic effect of CCL4 was controlled significantly (<0.05) by maintenance of structural integrity of hepatocyte cell membrane and normalisation of functional status of liver. Histology of liver sections from Solanum nigrum and Cichorium intybus + CCL4 treated rats revealed moderate centrilobular hepatocytes degeneration, few areas of congestion with mild fatty changes. The extract of Solanum nigrum and Cichorium intybus possess significant hepatoprotective activity in comparison to standard drug Silymarin.]]>Yu, C.H., C.F. Xu, H. Ye, L. Li and Y.M. Li,20101624352439Hayden, F.G.,20062006pp: 1243-1271pp: 1243-1271Nadeem, M., P.C. Dangiya, K.V. Pasha, M. Imara, D.K. Balani and S.B. Vohora,1997Solanum nigrum fruits.]]>58245254Dienstag, J.L.,20082008pp: 1949-1955pp: 1949-1955Bisset, N.G. and M. Wichtl,19942nd Edn.,pp: 566pp: 566Wagner, H.,19811981Kingsley, S.R. and S.J. Frankel,1939128131137Gowenlock, A., J.R. McMurray and M.D. Varleys,19816th Edn.,pp: 401-730pp: 401-730Reitman, S. and S. Frankel,1957285663Culling, C.F.A.,19743rd Edn.,pp: 76-91pp: 76-91Recknagel, R.O., E.A. Glende, Jr., J.A. Dolak and R.L. Waller,198943139154Sultana, S., S. Perwaiz, M. Iqbal and M. Athar,1995Solonum nigrum and Cichorium intybus inhibit free radical mediated DNA damage.]]>45189192Samudram, P., H. Rajeshwari, R. Vasuki, A. Geetha and P.S. Moorthi,20084 induced hepatic damage in rats.]]>3308314Baranisrinivasan, P., E.K. Elumalai, C. Sivakumar, S.V. Therasa and E. David,2009Enicostemma littorale blume and Eclipta alba during ethanol induced oxidative stress in albino rats.]]>5268272Malathi, R. and M.P. Gomez,2007Tylophora asthmatica against paracetamol induced liver damage in rats.]]>2737742Turel, I., H. Ozbek, R. Erten, A.C. Oner, N. Cengiz and O. Yilmaz,2009Plantago major L.]]>41120124Chavda, R., K.R. Vadalia and R. Gokani,2010Calotropis procera R. Br (Asclepediaceae).]]>6937943Prakash, O., G.N. Singh, R.M. Singh, S.C. Mathur, M. Bajpai and S. Yadav,20084282286Karim, A., M.N. Sohail, S. Munir and S. Sattar,20117419439Khadr, M.E., K.A. Mahdy, K.A. El-Shamy, F.A. Morsy, S.R. El-Zayat and A.A. Abd-Allah,20074 in rat.]]>739093917