International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.405.409Ficus exasperata Vahl (Moraceae) in Mice]]>WoodeEric PokuRosemary A.AbotsiWonder K.M.3201173Ficus exasperata Vahl (Moraceae) is a terrestrial afro-tropical tree used as an antiepileptic remedy in African traditional medicine. This study investigated the anticonvulsant effect of a hydroalcoholic leaf extract of F. exasperata against seizures induced by pentylenetetrazole, picrotoxin or maximal electroshock in mice. The extract (30-300 mg kg-1, p.o.) significantly delayed the onset and decreased the duration of pentylenetetrazole- and picrotoxin-induced convulsions. It also caused significant reduction in the duration of maximal electroshock-induced tonic hind limb extension of mice. In addition, at some anticonvulsant doses, the extract produced motor impairment on the rotarod. The present findings strongly indicate that the leaf extract of F. exasperata has anticonvulsant properties in mice and may explain its use as an antiepileptic agent in African traditional medicine.]]>Abotsi, W.M.K., E. Woode, G.K. Ainooson, A. Amo-Barimah and E. Boakye-Gyasi,2010Ficus exasperata P. Beauv.(Moraceae).]]>28997Akah, P.A., O.E. Orisakwe, K.S. Gamaniel and A. Shittu,199862123127Akula, K.K., A. Dhir and S.K. Kulkarni,200745720725Ayinde, B.A., E.K. Omogbai and F.C. Amaechina,2007Ficus exasperata Vahl (Moraceae) leaf.]]>64543546Berg, C.C.,1989Ficus.]]>45605611Berg, C.C. and J.T. Wiebes,1992Bhattacharya, S.K. and A.K. Sanyal,197856235237Castel-Branco, M.M., G.L. Alves, I.V. Figueiredo, A.C. Falcao and M.M. Caramona,200931101116De Sarro, A., V. Cecchetti, V. Fravolini, F. Naccari, O. Tabarrini and G. De Sarro,19994317291736Giardina, W.J.,20012001Goodman, L.S., M.S. Grewal, W.C. Brown and E.A. Swinyard,1953108168176Irene, I.I. and U.A. Iheanacho,2007Ficus exasperata vahl on kidney function in albino rats.]]>12729Irvine, F.R.,19611st Edn.,Lansky, E.P. and H.M. Paavilainen,20101st Edn.,Leewanich, P., M. Tohda, K. Matsumoto, S. Subhadhirasakul, H. Takayama, N. Aimi and H. Watanabe,1996Hunteria zeylanica.]]>19394399Loscher, W. and D. Schmidt,19882145181Mandhane, S.N., K. Aavula and T. Rajamannar,200716636644Meldrum, B.S. and M.A. Rogawski,200741861Mshana, N.R., D.K. Abbiw, I. Addae-Mensah, E. Adjanohoun and M.R.A. Ahyi et al.,20001st Edn.,Oliveira, F.A., R.N. De Almeida, M.F. Sousa, J.M. Barbosa-Filho, S.A. Diniz and I.A. De Medeiros,200168199202Piredda, S.G., J.H. Woodhead and E.A. Swinyard,1985232741745Sayyah, M., L. Nadjafnia and M. Kamalinejad,2004Artemisia dracunculus L. essential oil.]]>94283287Schmutz, M., C. Portet, A. Jeker, K. Klebs and A. Vassout et al.,19903426166Woode, E., R.A. Poku, G.K. Ainooson, E. Boakye-Gyasi, W.K.M. Abotsi, T.L. Mensah and A.K. Amoh-Barimah,2009Ficus exasperata (Vahl) leaf extract.]]>4138151