International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.363.369Hibiscus rosasinensis L. on Streptozotocin-Induced Diabetic Rats and the Possible Morphologic Changes in the Liver and Kidney]]>MandadeRajesh SreenivasS. A.3201173Medicinal plants play a major role in the management of Diabetes mellitus especially in developing countries. The present study investigated the possible therapeutic effects of Hibiscus rosasinensis (H. rosasinensis) extract on certain biochemical markers in Streptozotocin (STZ)-induced diabetes mellitus in rats. The effects of an aqueous ethanolic extract of H. rosasinensis Aerial part on blood glucose, albumin, albumin/globulin ratio, urea, insulin, C-peptide, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. Oral administration of H. rosasinensis (500 mg kg-1) aqueous extract to diabetic rats for 4 weeks significantly reduced blood glucose, urea, uric acid and creatinine but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. The present results shown that H. rosasinensis extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats.]]>Adhirajan, N., T.R. Kumar, N. Shanmugasundaram and M. Babu,2003In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn.]]>88235239Aliyu, R., A.H. Adebayo, D. Gatsing and I.H. Garba,2007Commiphora africana (Burseraceae) on rat liver and kidney functions.]]>2373379Almdal, T.P. and H. Vilstrup,198831114118Gilani, A.H., S. Bashir, K.H. Janbaz and A.J. Shah, 2005Hibiscus rosasinensis in constipation and diarrhoea.]]>102289294Asgary, S., G.A. Naderi, N. Sarrafzadegan and M. Ghasemi,199973223226Asgary, S., G.A. Naderi, S.N. Zadegan and R. Vakili,2002in vitro protein glycosylation.]]>24755Aurell, M. and S. Bjorck,1992413842Bakris, G.L.,19979389100Begum, N. and K.R. Shanmugasundaram,19784116122Brownlee, M.,2001414813820Dubey, G.P., S.P. Dixit and S. Alok,199426225226Gupta, V., P. Bansal, A. Garg and A.K. Meena,2009Hibiscus rosa sinensis Linn.]]>1124126Jadhav, V.M., R.M. Thorat, V.J. Kadam and N.S. Sathe,2009Hibiscus rosa-sinensis.]]>212201222Jorda, A., M. Gomez, J. Cabo and S. Grisolia,19821063743Kasture, V.S., C.T. Chopde and V.K. Deshmukh,2000Albizzia lebbeck, Hibiscus rosa sinesis and Butea monosperma in experimental animals.]]>716575Kikkawa, R., D. Koya and M. Haneda,2003411921King, K.J. and A.L. Armstrong,19881988pp: 457-461pp: 457-461Krishnakumar, K., K.T. Augustii and P.L. Vijayammal,199943510514Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Mansour, H.A. and A.A. Newairy,2000Balanites aegyptiaca fruits in streptozotocin induced diabetic rats.]]>21115125Mauer, S.M., M.W. Steffes and D.M. Brown,198170603612McLennan, S.V., S. Heffernan and L. Wright,199140344348Prince, P.S.M., V.P. Menon and L. Pari,1997Syzigium cumini extracts on hepatic hexokinase and glucose-6-phosphatase in experimental diabetes.]]>2529531Pullaiah, T.,2002pp: 143-144, 288pp: 143-144, 288Reinhold, J.,19801980pp: 545-547pp: 545-547Rosalki, S.B. and D. Rau,1972394147Ross, R.,1999340115126Saeed, A., N. Ibrahim, S. Bashandy and S. El-Gengaihi,199533105109Saxena, A. and N.K. Vikram,200410369378Schwartz, S.L.,20068355364Sethi, N., D. Nath and R.K. Singh,1986Hibiscus rosa-sinensis in rats.]]>128688Sharma, S., M. Anjanevulu, S.K. Kulkarni and K. Chopra,200676172178Shinde, U.A. and R.K. Goyal,20037322329Thirunavukkarasu, V., C.V. Anuradha and P. Viswanathan,2003Trigonella foenum graecum) seeds in experimental ethanol toxicity.]]>17737743Tuvemo, T., U. Ewald, M. Kobbah and L.A. Proos,199786710Udoh, A.E., I. Ntu, O. Essien and M. Ndon,20076511515Virella-Lopes, M.F. and G. Virella,20038750768WHO.,1999pp: 1-58pp: 1-58Dandu, A.M. and N.M. Inamdar,2008Andrographis paniculata against endothelial dysfunction in diabetic wistar rats.]]>3311317Atangwho, J.J., P.E. Ebong, M.U. Eteng, E.U. Eyong and A.U. Obi,2007Vernonia amygdalina del leaf on kidney function of diabetic rats.]]>3143148Al-Attar, A.M. and T.A. Zari,200733440Rahman, M.W., M. Mostofa, S.A. Sardar, M.R. Sultana, M.M. Haque and M.E. Choudhury,2005Azadirachta indica), karala (Momordica charantea) and nayantara (Cathranthus roseus) with glibenclamide on rat.]]>1257260Saravanan, G. and L. Pari,2008Syzygium cumini bark in streptozotocin-induced diabetic rats.]]>3110Safiyeh, S., F. Fathallah, N. Vahid, S.S. Habib and N. Nabat,2007Equisetum arvense L. (Equisetaceae) in microalbuminuria and creatinine excretion in streptozotocin-induced diabetes in male rats.]]>3155159Zanna, H., S. Adeniji, B.B. Shehu, S. Modu and G.M. Ishaq,2008Hyphaene thebaica (L.) mart on some indicators of liver and kidney function in rats.]]>3330334Rathi, A., C.V. Rao, S. Khatoon and S. Mehrotra,2003Peristrophe bicalyculata Nees for anti-inflammatory and analgesic activity.]]>9195199Rao, G.M., L.O. Morghmom, M.N. Kabur, B.M. Ben Mohamed and K. Ashibani,198943118121Rao, B.K. and C.H. Rao,2001Syzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats.]]>88893