International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.278.282AlanyaliF. SusuzArtaganO. YukselS. 2201172The aim of this study was to evaluate the mutagenic potential of newly synthesized eight Benzylideneaniline derivatives by using the Salmonella mutagenicity test, using two strains of Salmonella typhimurium carrying frameshift (TA 98) and base-pair substitution (TA 100) mutations. Strains were used in plate incorporation method in the absence and presence of metabolic activation. In a general manner, 4-chloro, 4-methoxy, 4-nitro, 4-methyl, 2 methoxy, 3-nitro derivatives were found to be mutagenic in TA 100 in the absence of metabolic activation. 4-hydroxy benzylidenaniline and 4-bromo benzylidenaniline exhibited direct mutagenicity in TA 98 in the absence of metabolic activation. In the presence of S9 (metabolic activation) mix, 4-methoxy benzylidenaniline, 4-nitro benzylidenaniline, 2-methoxy benzylidenaniline, 3-nitro benzylidenaniline compounds gave mutagenic results in TA 98 and 4-methoxy benzylidenaniline, 2-methoxy benzylidenaniline, 3-nitro benzylidenaniline compounds in TA 100. Mutagenicity of 4 compounds (4-chloro, 4-nitro, 4-methyl, 4-hydroxy) completely disappeared in TA 100 strain by the use of S9 (metabolic activation) mix. Compounds with nitro and methoxy groups exhibited greater mutagenicity in both strains in the presence and absence of metabolic activation.]]>Ames, B.N., J. McCann and E. Yamasaki,1975Salmonella/mammalian microsome mutagenicity test.]]>31347364Aydogan, G. and M. Kutlu,2007Salmonella typhimurium.]]>62612Benkli, K., Y. Tunali, Z. Canturk, O. Artagan and F. Alanyali,20093]2+ evaluated by Ames/Salmonella and MTT methods.]]>4426012605Chung, K.T., S.C. Chen, T.Y. Wong, Y.S. Li, C.I. Wei and M.W. Chou,200056351356Claxton, L.D. and G.M. Woodall Jr.,20076363694Jagetia, G.C., A. Jayakrishnan, D. Fernandes and M.S. Vidyasagar,2001491916Josephy, P.D., P. Gruz and T. Nohmi,1997386123Kaplan, C., N. Diril, S. Sahin and M.C. Cehreli,2004Salmonella/microsome test.]]>2540194027Kutlu, M., G. Aydogan and E. Mumcu,20074520642068Mamber, S.W., B. Kolek, K.W. Brookshire, D.P. Bonner and J. Fung-Tomc,1993Salmonella TA 102 mutagenicity test and other bacterial genotoxicity assays.]]>37213217Maron, D.M. and B.N. Ames,1983Salmonella mutagenicity test.]]>113173215Mortelmans, K. and E. Zeiger,2000Salmonella/microsome mutagenicity assay.]]>4552960Ozkay, Y., Z. Incesu, I. Isıkdag and M. Yesilkaya,200626102106Waters, M.D., A.L. Brady, H.F. Stack and H.E. Brockman,19902385785Wyszyn, S.K. and W.C. Liro,19913233