International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.217.227HaleagraharaNagaraja JackieTan ChakravarthiSrikumar KulurAnupama Bangra2201172The present study was designed to investigate the effects of alpha Lipoic Acid (LA) against lead acetate induced changes in free radical scavenging enzymes and lipid hydroperoxides in bone marrow of rats. Rats were exposed to lead acetate in their drinking water (500 ppm) for 14 days and alpha lipoic acid was given concurrently (25, 50 and 100 mg kg-1). Blood lead levels, lipid hydroperoxides, protein carbonyl contents and oxidative marker enzymes were estimated. Lead acetate in drinking water had elicited a significant (p<0.05) increase in bone marrow lipid hydroperoxides (LPO) (p<0.05) and Protein-Carbonyl-Contents (PCC). 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