International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2011.12.21MohammadiradAzadeh AbdollahiMohammad 1201171The purpose of this study was to provide a systematic review on the animal or human evidences linking aluminium (Al) toxicity to oxidant/antioxidant imbalance. Embase, Scopus, Pubmed, Web of Science, Google Scholar and SID databases were searched up to 1st October 2010. Over 50 studies including animal and human linking oxidative stress to Al were reviewed. Most of animal and human studies show a significant increase in lipid peroxidation (LPO) by Al. The maximum LPO was reported in the brain. Data about changes of enzymatic antioxidants such as Superoxide Dismutase (SOD), Catalase (CAT), Glutathione Peroxidase (GPx) post exposure to Al are controversial. Animal studies showed that vitamin E, C, melatonin and pinoline reduce LPO in Al-exposed subjects. 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