International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2010.926.929Ruta graveolens on Spermatogenesis of Adult Rats]]>BazrafkanM. PanahiM. SakiG. AhangarpourA. ZaeimzadehN. 6201066In this study the effect of aqueous extract of RG on spermatogenesis of rat has been investigated. Animals were allocated into three groups as: (1) control which did not receive anything, (2) vehicle which received only normal saline (the same volume as 3rd group according to the weight) and (3) experiment which received ruta extract (300 mg kg-1 intraperitoneally once a day for 50 days). A day after last injection the animals were deeply anesthetized and dissected. The right testes were extruded and fixed for histological studies. For statistical analysis ANOVA and Tukey as a post hoc. test were used. There was a significant decrease in the number of spermatogonia (p<0.01), primary spermatocyte (p<0.05), spermatid (p<0.05) and lydig cells (p<0.01) in experimental group as compared to control and vehicle. Also there were a significant increase in thickness of tunica albugina (p<0.01) and decrease in seminiferous tubule diameter (p<0.05) in experimental group compared to control and vehicle. So, it is concluded that the aqueous extract of Ruta graveolens diminishes the reproductive system activity and might be a useful substance for birth control process.]]>Ahmadi, A.,20052005Bone, W., A.R. Jones, C. Morin E. Nieschlag and T.G. Cooper,2001in vitro.]]>22464470Ciganda, C. and A. Laborde,200341235239Chiu, K.W. and A.Y. Fung,1997Phaseolus aureus), common rue (Ruta graveolens) and kelp (Laminaria japonica) in rats.]]>29859862De Freitas, T.G., P.M. Augusto and T. Montanari,2005Ruta graveolens L. on pregnant mice.]]>717477Diawaraa, M.M., K.J. Chavez, D. Simpleman, D.E. Williams, M.R. Franklin and P.B. Hoyer,200115137144Gutierrez-Pajares, J.L., L. Zuniga and J. Pino,2003Ruta graveolens L. aqueous extract retards mouse preimplantation embryo development.]]>17667672Harat, Z.N., M.R. Sadeghi, H.R. Sadeghipour, M. Kamalinejad and M.R. Eshraghian,2008Ruta graveolens L. on human sperm: A new hope for male contraception.]]>1153641Khouri, N.A. and Z. El-Akawi,2005Ruta graveolens L. in male Albino rats with emphasis on sexual and aggressive behavior.]]>26823829Meepagala, K.M., K.K. Schrader, D.E. Wedge and S.O. Duke,2005Ruta graveolens and synthesis of their analogs.]]>6626892695Ojala, T., S. Remes, P. Haansuu, H. Vuorela, R. Hiltunen, K. Haahtela and P. Vuorela, 200073299305Oliva, A., K.M. Meepagala, D.E. Wedge, D. Harries, A.L. Hale, G. Aliotta and S.O. Duke,2003Ruta graveolens L. leaves, including a new quinolone alkaloid.]]>51890896Petrunkina, A.M., R.A. Harrison, M. Hebel, K.F. Weitze and E. Topfer-Petersen,2001122327336Rahim, F., G. Saki, B. Ghavamizadeh, A. Jafaee and M. Kadkhodaee,2009in vitro.]]>5178180Rahim, F., G. Saki and M. Bazrafkan,2010Ruta graveolens L. on the count, motility and in vitro fertilization capacity of rat's sperm.]]>96366Raghav, S.K., B. Gupta, C. Agrawal, K. Goswami and H.R. Das,2006Ruta graveolens L. in murine macrophage cells.]]>104234239Ramesh, B. and K.V. Pugalendi,20069562566Rethy, B., I. Zupko, R. Minorics, J. Hohmann, I. Ocsovszki and G. Falkay,2007Ruta graveolens.]]>734148Sailani, M.R. and H. Moeini,2007Ruta graveolens and Cannabis sativa alcoholic extract on spermatogenesis in the adult wistar male rats.]]>23257260Tabib, M.M.H.,1958pp: 143pp: 143Williams, C.D.,1966603339Waites, G.M.H.,200380115Zargari, A.,19904th Edn.,pp: 1-57pp: 1-57