International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2010.691.695RanjbarS. Hasani-VahidiH. TaslimiS. KarimiN. LarijaniB. AbdollahiM. 5201065Several drugs may increase blood prolactin concentration. Dopamine receptor antagonists are one of the most common causes of hyperprolactinemia. To reduce happening of hyperprolactinemia, some medicinal plants have been traditionally used. This review focuses on the efficacy of effective herbal medicines in the management of human drug-induced hyperprolactinemia. PubMed, Scopus, Web of science, Cochrane library database were searched for any relevant studies that investigated the effect of herbal medicines on drug induced hyperprolactinemia up to May 2010. The inclusion criteria were clinical trials studied efficacy of herbal medicines in drug-induced hyperprolactinemia. Among different compounds, four herbal supplements including Shakuyaku-kanzo-to (TJ-68), Peony-Glycyrrhiza Decoction (PGD), Zhuangyang capsule, Tongdatang serial recipe (TDT) were found clinically effective and safe in management of drug-induced hyperprolactinemia. Although, the quality of included clinical trials was low not allowing us to conduct a meta-analysis but positive results on efficacy (TJ-68), (PGD), Zhuangyang capsule and (TDT) cannot be ignored. Interestingly compounds with prolactin-suppressive effects have a number of diterpenes mainly clerodadienols that seem almost identical for their efficacy. Further studies to isolate and characterize constituents of the effective herbs are needed to reach novel therapeutic and more effective agents.]]>Casanueva, F.F., M.E. Molitch, J.A. Schlechte, R. Abs and V. Bonert et al.,200665265273Chen, Z., G. Wang, X. Wang, L. Li and D. Xiao,200829798800David, S.R., C.C. Taylor, B.J. Kinon and A. Breier,20002210851096Ding, Y., H.Z. Qian and Y.Q. Wang,200828263265, (In Chinese)Gillam, M.P., M.E. Molitch, G. Lombardi and A. Colao,200627485534Hasani-Ranjbar, S., N. Nayebi, B. Larijani and M. Abdollahi,20091530733085Hasani-Ranjbar, S., B. Larijani and M. Abdollahi,20084, 3285292Hasani-Ranjbar, S., N. Nayebi, B. Larijani and M. Abdollahi,2010Teucrium species; from anti-oxidant to anti-diabetic effects.]]>6315325Hasani-Ranjbar, S., B. Larijani and M. Abdollahi,20098210Mancini, T., F.F. Casanueva and A. Giustina,2008376799Markianos, M., J. Hatzimanolis and L. Lykouras,2001251141146McCallum,J.R., R.W., Sowers, J.M. Hershman and R.A.L. Sturdevant,19764211481152Moher, D., A.R. Jadad, G. Nichol, M. Penman, P. Tugwell and S. Walsh,1995166273Mohseni-Salehi-Monfared, S.S., H. Vahidi, A.H. Abdolghaffari, S. Nikfar and M. Abdollahi,20091544814490Monfared, S.S.M.S., B. Larijani and M. Abdollahi,20091511531161Momtaz, S. and M. Abdollahi,2010Satureja species; From antioxidant, antimicrobial, antidiabetes and anti-hyperlipidemic to reproductive stimulation.]]>6346353Patel, S.S. and V. Bamigboye,200727455459Perala, J., J. Suvisaari, S.I. Saarni, K. Kuoppasalmi and E. Isometsa et al.,2007641928Perovich, R.M., J.A. Lieberman, W.W. Fleischhacker and J. Alvir,19899417422Rahimi, R., S. Mozaffari and M. Abdollahi,200954471480Rahimi, R., S. Ghiasi, H. Azimi, S. Fakhari and M. Abdollahi,201049123129Rahimi, R., S. Nikfar, B. Larijani and M. Abdollahi,200559365373Salari, P., A. Rezaie, B. Larijani and M. Abdollahi,200814RA3744Rivera, J.L., S. Lal, P. Ettigi, S. Hontela, H.F. Muller and H.G. Friesen,19765273282Sowers, J.R., B. Sharp and R.W. McCallum,198254869871Tollin, S.R.,200023765770Torre, D.L. and A. Falorni,20073929951Vance, M.L., W.S. Evans and M.O. Thorner,19841007891Wuttke, W., H. Jarry, V. Christoffel, B. Spengler and D. Seidlova-Wuttke,200310348357Yamada, K., S. Kanba, T. Murata, M. Fukuzawa, B. Terashi, G. Yagi and M. Asai,199650341342Yamada, K., S. Kanba, G. Yagi and M. Asai,199717234235Yamada, K., G. Yagi and M. Asai,199919380381Yuan, H.N., C.Y. Wang, C.W. Sze, Y. Tong and Q.R. Tan et al.,200828264270