International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2010.686.690In vivo Anti-inflammatory and in vitro Antioxidant Activities of Peperomia pellucida]]>MuteeA. F.SalhimiS. M.YamM. F.LimC. P.AbdullahG. Z.AmeerO. Z.AbdulkarimM. F.AsmawiM. Z.5201065Peperomia pellucida is widely used in the traditional medicine such as in the treatment of inflammation, gout, arthritis and wound healing. The present study was performed to evaluate the anti-inflammatory and antioxidant effects of petroleum ether, chloroform and methanol extracts of P. pellucida. The carrageenan-induced rat hind paw edema method was performed to evaluate the anti-inflammatory effect in vivo and the determination of free radical scavenging activity method was carried out to assess the antioxidant effect in vitro. For the anti-inflammatory activity, 1000 mg kg-1 of petroleum ether extract significantly reduced carrageenan-induced hind paw edema (p<0.05) compared with the control (p<0.01). However, there was no significant anti-inflammatory activity for chloroform and methanol extracts. The antioxidant effect was evaluated by determining the free radical scavenging activity of the three extracts. The total phenol content was determined for the methanol extract (6.93%) that showed the strongest free radical scavenging activity (0.083 mg mL-1 ±0.008). Petroleum ether and chloroform showed low free radical scavenging activity compared to methanol extract. The results obtained from this study suggest that this plant is a good natural source for anti-inflammatory and antioxidant therapy.]]>Antonio, M.A. and A.R.M.S. Brito,1998Turnera ulmifolia (Turneraceae).]]>61215228Aziba, P.I., A. Adedeji, M. Ekor and O. Adeyemi,2001Peperomia pellucida aerial parts in mice.]]>725758Chiang, H.C., Y.J. Lo and F.J. Lu,1994Alsophila spinulosa (Hook) Tryon.]]>86171Conforti, F., S. Sosa, M. Marrelli, F. Menichini and G.A. Statti et al.,2008In vivo anti-inflammatory and in vitro antioxidant activities of Mediterranean dietary plants.]]>116144151De Fatima Arrigoni-Blank, M., E.G. Dmitrieva, E.M. Franzotti, A.R. Antoniolli, M.R. Andrade and M. Marchioro,2004Peperomia pellucida (L.) HBK (Piperaceae).]]>91215218Di Rosa, M.,19722489102Di Rosa, M., J.P. Ground and D.A. Willoughby,19711041529Han, X., T. Shen and H. Lou,20078950988Khan, A., M. Rahman and M.S. Islam,2008P. pellucida leaves in mice.]]>163540Khan, M.R. and A.D. Omoloso, 2002Hygrophila stricta and Peperomia pellucida.]]>73251254Kim, S.Y., J.J. Gao, W.C. Lee, K.S. Ryu, K.R. Lee and Y.C. Kim,1999Morus alba.]]>228185Koleva, I.I., T.A. van Beek, J.P.H. Linssen, A. de Groot and L.N. Evstatieva,200213817Kumaran, A. and R.J. Karunakaran,2006Coleus aromaticus.]]>97109114Omisore, N.O., C.O. Adewunmi, E.O. Iwalewa, B.T. Ngadjui and T.K. Adenowo et al.,2005Dorstenia barteri and Dorstenia convexa.]]>3810871094Plumb, G.W., K.R. Price and G. Williamson,19994123127Ragasa, C.Y., M. Dumato and J.A. Rideout,1998Peperomia pellucida.]]>75461Rang, H.P., M.M. Dale and J.M. Ritter,19994th Edn.,Soare, J.R., T.C.P. Dinis, A.P. Cunha and L. Almeida,1997Thymus zygis.]]>26469478Slinkard, K. and V.L. Singleton,1977284955Sosa, S., M.J. Balick, R. Arvigo, R.G. Esposito, C. Pizza, G. Altinier and A. Tubaro,20028211215Tandon, V.R. and R.K. Gupta,2006Vitex negundo Linn.]]>2303308Vinegar, R., W. Schreiber and R. Hugo,196916696103Winrow, V.R., P.G. Winyard, C.J. Morris and D.R. Blake,199349506522Winter, C.A., E.A. Risley and G.W. Nuss,1962111544547Xu, S., N. Li, M.M. Ning, C.H. Zhou, Q.R. Yang and M.W. Wang,2006Peperomia pellucida.]]>69247250Sawadogo, W.R., R. Boly, M. Lompo, N. Some, C.E. Lamien, I.P. Guissou and O.G. Nacoulma,2006Dicliptera verticillata.]]>2435438Goncalves, C., T. Dinis and M.T. Batista,2005Uncaria tomentosa bark decoction: A mechanism for anti-inflammatory activity.]]>668998