International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2010.63.67ommelina benghalensis Linn]]>HasanS.M. RaquibulHossainM. M.AkterR. JamilaM. MazumderM. E.H.AlamM. A.FaruqueA. RanaS. RahmanS. 1201061Analgesic potential of the pet ether (PECB), chloroform (CCB), n-butanol (NBCB) and hydromethanolic (HMCB) fractions of the aerial parts of Commelina benghalensis Linn. was evaluated for centrally acting analgesic property using hotplate and tail immersion method and peripheral pharmacological actions using acetic acid-induced writhing test to scientifically validate some of the folkloric and ethnomedical uses of the plant. All fractions, at the dose of 200 and 400 mg kg-1 b.wt., displayed significant analgesic action in a dose dependent manner in the tested models. In acetic acid-induced writhing test, all extracts exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; the response decreased in the order Diclofenac-Na (76.16%) > CCB2 (68.8%) > NBCB2 (61.9%) > HMCB2 (52.8%) > PECB2 (48.0%). In hotplate and tail immersion method, all fractions caused a significant (p<0.0-0.001) increase in latency time and the results are comparable to the standard drug Nalbuphine. These results suggest significant analgesic potential of C. benghalensis and thereby justify its traditional uses in various types of pain.]]>Ahmed, F., M.S.T. Selim, A.K. Das and M.S.K. Choudhuri,2004Lippia nodiflora Linn.]]>59329330Ahmed, F., M.H. Hossain, A.A. Rahman and I.Z. Shahid,2006Cerbera odollam Gaertn.]]>6344348Almeida, R.N., R.N. Almeida, D.S. Navarro and J.M. Barbosa-Filho,20018310322Brown, J.E. and C.A. Rice-Evans,1998in vitro.]]>29247255Deyuan, H. and A.D. Robert,20002000pp: 36pp: 36Eddy, N.B. and D. Leimbach,1953107385393Elisabetsky, E., T.A. Amador, R.R. Albuquerque, D.S. Nunes and A.D.C.T. Carvalho,1995Psychotria colorata (Willd. ex R. and S.) Muell. Arg. alkaloids.]]>487783Ferdous, M., R. Rouf, J.A. Shilpi and S.J. Uddin,2008Ficus racemosa Lin. (Moraceae).]]>89396Franzotti, E.M., C.V.F. Santos, H.M.S.L. Rodrigues, R.H.V. Mourao, M.R. Andrade and A.R. Antoniolli,2000Sida cordifolia L. (Malva-branca).]]>72273277Ghani, A.,20032nd Edn.,Pages: 603Pages: 603Ibironke, G.F. and K.I. Ajiboye,2007Chenopodium ambrosioides leaf extract in rats.]]>3111115Krinsky, N.I.,200117815817Kulkarni, S.K.,19993rd Edn.,pp: 115-133pp: 115-133Mate, G.S., N.S. Naikwade, C.S.A.A. Chowki and S.B. Patil, 2008Cissus quadrangularis on albino mice.]]>2118121Okello, J. and P. Ssegawa,2007457683Pal, S., T. Sen and A.K.N. Chaudhuri,1999Bryophyllum pinnatum leaf extract.]]>51313318Qaiser, M. and S.M.H. Jafri,19751975pp: 10pp: 10Ramesh, M., Y.N. Rao, A.V.N.A. Rao, M.C. Prabhakar, C.S. Rao, N. Muralidhar and B.M. Reddy,1998Caralluma attenuata.]]>626366Raju, M., S. Varakumar, R. Lakshminarayana, T.P. Krishnakantha and V. Baskaran,200710115981605Rajnarayana, K., M.S. Reddy, M.R. Chaluvadi and D.R. Krishna,200133216Samant, S.S. and S. Pant,200632847Tabuti, J.R.S., K.A. Lye and S.S. Dhillion,2003881944Toma, W., J.S. Graciosa, C.A. Hiruma-Lima, F.D.P. Andrade, W. Vilegas and A.R.M.S. Brita,2003Quassia amara bark extract.]]>851923Tripathi, K.D.,19994th Edn.,Pages: 432Pages: 432Vinson, J.A., Y.A. Dabbagh, M.M. Serry and J. Jang,1995in vitro oxidation model for heart disease.]]>4328002802Ssenyonga, M. and E. Brehony,199397575