International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2010.157.172AshokP. KyadaA. SubbaraoP. SutharS. SinghD. VadaliyaK. 3201063In the present investigation, antidiabetic and antioxidant activities of a polyherbomineral formulation, Gly-13-C was evaluated in streptozotocin-induced diabetic male Wistar rats and compared with that of glibenclamide (600 μg kg-1), a reference drug. After induction of diabetes by a single intraperitoneal injection of streptozotocin (65 mg kg-1), diabetic animals were treated with different doses of Gly-13-C (100, 200 mg kg-1 and 400 mg kg-1 b.wt.) for 21 days. Various biochemical parameters-fasting plasma glucose, albumin fructosamine levels, liver enzymatic antioxidants like superoxide dismutase, catalase, non-enzymatic antioxidants like vitamin C and E, lipid peroxidation in liver and glycogen biosynthesis in liver and skeletal muscle were measured. 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