International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2010.111.116TamtaA. ChaudharyM. SehgalR. 2201062The objective of current study was to evaluate deleterious effects of a potential combination of cefpirome, a member of the latest class of broad-spectrum cephalosporins, in combination of β-lactamase inhibitor, sulbactum. To assess the toxicity profile of fixed dose regimen Pirotum (Cefpirome+Sulbactum in 2:1 ratio), a repeated dose subacute toxicity study was conducted on Swiss albino mice and Wistar rat (male and female). Three different dose levels (30, 60 and 120 mg kg-1) of combination were administered for twenty eight days. Physical parameters, hematological parameters and biochemical parameters related to liver toxicity and nephrotoxicity were evaluated as end point parameters. Findings of present study were also supported by hematological as well as histopathology parameters. Data of current study indicated that Pirotum exerted no deleterious effect on blood, liver and kidney function as no alteration was observed in biochemical parameters at any dose level.]]>Barnaud, G., R. Labia, L. Raskine, M.J.S. Pors, A. Philippon and G. Arlet,2001Enterobacter cloacae clinical isolate.]]>195185190Deki, T., S. Higo, Y. Sakamaki, T. Uchiyama, T. Ohtani, S. Kokuba and Y. Kumagai,199031152Donaubauer, H.H., K. Engelbart and D. Mayer,19904010341038Donaubauer, H.H. and D. Mayer,1992297173Hancock, R.E.,19921992pp: 1104Hancock, R.E.W. and F. Bellido,19922916Horstmann, G. and K. Engelbart,19904012501259Ishii, Y., J. Alba, S. Kimura, K. Shiroto and K. Yamaguchi,200525296301Ishii, Y., K. Tateda and K. Yamaguchi,200860177183Kinzig, M., F. Sorgel, B. Brismar and C.E. Nord,19923619972004Korvick, J.A., C.S. Bryan, B. Farber, T.R. Beam and L. Schenfeld et al.,19923626392644Lewis, M.T., K. Yamaguchi, D.J. Biedenbach and R.N. Jones,1999In vitro evaluation of cefepime and other broad-spectrum beta-lactams in 22 medical centers in Japan: A phase II trial comparing two annual organism samples.]]>35307315Lipman, J., S.C. Wallis and R.J. Boots,20039711491154Lipman, J., S.C. Wallis, C.M. Rickard and D. Fraenkel,200127363370Meis-Kindblom, J.M. and L.G. Kindblom,199822911924Muller, M., A. dela Pena and H. Derendorf,20044814411453Rice, L.B., J.D. Yao, K. Klimm, G.M. Eliopoulos and R.C. Moellering,19913512431244Sauermann, R., G. Delle-Karth, C. Marsik, I. Steiner and M. Zeitlinger et al.,200549650655Sirot, D., J. Sirot, R. Labia, A. Morand and P. Courvalin et al.,198720323334Tikoo, K., A. Tamta, I.Y. Ali, J. Gupta and A.B. Gaikwad,20081779096Wiseman, L.R. and H.M. Lamb,199754117140