International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2009.51.57A. ZidanNour El-Hoda 1200951The toxic effects of organophosphorus pesticides (i.e., chlorpyrifos methyl, diazinon and profenofos) on male reproductive system of rats were evaluated. Rats received pesticides mixed with powdered feed at concentrations of 5 and 50 ppm of each pesticide for 65 successive days. Sex organs weight, semen picture, concentrations of the hormones [i.e., testosterone, Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH)], activities of acetylcholinesterase (AChE) and histopathological changes in testes were the criteria used to evaluate the reproductive toxicity of the treated rats. Results showed that the effect of all tested pesticides on testes and seminal vesicles weights was dose-dependent since all tested pesticides at 50 ppm significantly decreased their weights. Serum AChE activity was inhibited with all tested pesticides. Both the concentrations of the tested pesticides decreased sperm count associated with increase in the number of morphologically abnormal spermatozoa of treated rats; however sperm motility was significantly decreased with the highest concentration of the tested pesticides. A decrease in the serum testosterone was observed in all treated groups; however LH and FSH levels were decreased with the highest concentration of the tested pesticides. Tissues of treated rat’s testes showed slight alterations when histopathologically examined especially with the higher concentrations.]]>Abd El-Aziz, M.I., A.M. Sahlab and M. Abd El-Khalik,1994101230232Den Blawen, D.H., W.A. Poppe and W. Trischler,198321381386Doul, J., C.D. Klassen and M.O. Amdur,19802nd Edn.,Farag, A.T., A.F. El-Aswad and N.A. Shaaban,200723232238Gore, A.C.,200114235246Gupta, R.C.,20062006Guven, M., F. Bayram, K.Unluhizarci and F. Kelestimur,199918598601Guyton, A.C.,19918th Edn.,Guzick, D., J. Overstreet, P. Factor-Litvak, C.K. Brazil and S.T. Nakajima et al.,200134513881393Harris, H.E.,18984th Edn.,Herken, H. and D. Neubert,1953219222233Holdcraft, R.W. and R.E. Braun,200427335342Jana, D., R. Maiti and D. Gosh,20035125129Jeong, S.H., B.Y. Kim, H.G. Kang, H.O. Ku and J.H. Cho,20052084962Jeong, S.H., B.Y. Kim, H.G. Kang, H.O. Ku and J.H. Cho,2006220189202Johnson, R.A., R.E. Harris and R.A. Wilke,2000993438Kamijima, M., H. Hibi, M. Gotoh, K. Taki and I. Saito et al.,200446109118Kang, H.G., S.H. Jeong, J.H. Cho, D.G. Kim, J.M. Park and M.H. Cho,2004199219230Karanth, S. and C. Pope,2003In vitro inhibition of blood cholinesterase activities from horse, cow and rat by tetrachlorvinphos.]]>22429433Kimbrough, R.D., R.E. Linder and T.B. Gaines,197225354364Kitamura, S., T. Suzuki, S. Otha and N. Fujimoto,2003111503508Krause, W.,197718231242Latchoumycandane, C., K.C. Chitra and P.P. Mathur,200216161172Litovitz, T.L., W. Klein-Schwartz, S. White, D.J. Cobaugh, J. Youniss, A. Drab and B.E. Benson,199816443497Lyons, G.,1999Mathew, G., K.K. Vijayalaxmi and M.A. Rahiman,1992280169173McDaniel, K.L. and V.C. Moser,200426407415Moustafa, G.G., Z.S. Ibrahim, Y. Hashimoto, A.M. Alkelch, K.Q. Sakamoto, M. Ishizuka and S. Fujita,200781875881Mycek, M.J., R.A. Harvey and P.C. Champe,19972nd Edn.,National Resources Defense Council,19981998Okamura, A., M. Kamijima, E. Shibata, K. Ohtani and K. Takagi et al.,2005213129137Okazaki, K., S. Okazaki, S. Nishimura, H. Nakamura and Y. Kitamura et al.,200175513521Padungtod, C., B.L. Lasley, D.C. Christiani, L.M. Ryan and X. Xu,19984010381047Padungtod, C., D.A. Savitz, J.W. Overstreet, D.C. Christiani, L.M. Ryan and X. Xu,200042982992Price, D. and H.G. Williams-Ashman,19611961p: 336p: 336Ray, A., S. Chatterjee, S. Ghosh, K. Bhattacharya, A. Pakrashi and C. Deb,199257181189Ray, A., S. Chatterjee, S. Ghosh, S.N. Kabir, A. Pakrashi and C. Deb,199121383387Rind, G.L., D. Guseppe and U. Venture,196381147154Sarkar, R., K.P. Mohanakumar and M. Chowdhury,20001182938Saunders, P.T.,20036191101Sherins, R.J. and S.S. Hawards,19781978pp: 715pp: 715Simoni, M., G.F. Weinbauer, J. Gromoll and E. Nieschlag,199960102106Sinha, N., R. Narayan, R. Shanker and D.K. Saxena,199537547549Takihara, H., M.J. Cossentino, J. Sakotoku and A.T.K. Cockett,1987137416419Walsh, L.P., C. McCormick, C. Martin and D.M. Stocco,2000108769776